Analysis of Atg5 dependent and independent autophagy and induction mechanism of inflammation during bacterial infection.
| Project/Area Number |
25293370
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Kyoto University (2014-2015)
Tokyo Medical and Dental University (2013) |
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Principal Investigator |
NAKAGAWA ICHIRO 京都大学, 医学(系)研究科(研究院), 教授 (70294113)
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| Co-Investigator(Kenkyū-buntansha) |
Maruyama Fumito 京都大学, 大学院医学研究科, 准教授 (30423122)
野澤 孝志 京都大学, 医学(系)研究科(研究院), 助教 (10598858)
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| Co-Investigator(Renkei-kenkyūsha) |
NOZAWA TAKASHI 京都大学, 大学院医学研究科, 助教 (10598858)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | A群レンサ球菌 / xenophagy / オートファジー / Rabタンパク質 / 炎症 / Rab30 / Rab9 / Rab23 / Rab17 / 認識分子 / 炎症誘導 / Atg5 |
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| Outline of Final Research Achievements |
Autophagy in mammalian cells not only supplies nutrients under starvation conditions but also protects against human diseases by selectively degrading aggregated proteins, damaged organelles, and invading microbes. Rab proteins are localized to distinct intracellular membranes and vesicles and function as molecular switches that alternate between two conformational states. We found that GcAV-regulating Rab proteins include Rab9A and Rab23, which are dispensable for starvation-induced autophagy. Autophagy involves highly conserved cellular machinery, has various physiological roles, and plays a role in immunity against intracellular pathogens. Our findings suggest that autophagy uses involves Rab proteins during distinct stages of development. Further studies examining autophagy during GAS infection will help define these detailed interactions between host cells and bacterial pathogens.
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Report
(4 results)
Research Products
(62 results)
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[Journal Article] Development of a two-step multiplex PCR assay for typing of capsular polysaccharide synthesis gene clusters of Streptococcus suis2014
Author(s)
Okura M, Lachance C, Osaki M, Sekizaki T, Maruyama F, Nozawa T, Nakagawa I, Hamada S, Rossignol C, Gottschalk M, Takamatsu D
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Journal Title
J Clin Microbiol
Volume: 52
Issue: 5
Pages: 1714-1719
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Comparative genomic characterization of a Thailand-Myanmar isolate, MS6, of Vibrio cholerae O1 El Tor, which is phylogenetically related to a "US Gulf Coast" clone.2014
Author(s)
K. Okada, M. Na Ubol, W. Natakuathung, A. Roobthaisong, F. Maruyama, I. Nakagawa, S. Chantaroj, S. Hamada
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Journal Title
PLos One
Volume: 9
Issue: 6
Pages: e98120-e98120
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Endogenous nitrated nucleotide is a key mediator of autophagy and innate defense against bacteria.2013
Author(s)
Ito C, Saito Y, Nozawa T, Fujii S, Sawa T, Inoue H, Matsunaga T, Khan S, Akashi S, Hashimoto R, Aikawa C, Takahashi E, Sagara H, Komatsu M, Tanaka K, Akaike T, Nakagawa I, Arimoto H.
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Journal Title
Mol. Cell
Volume: 52
Issue: 6
Pages: 794-804
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Complete genome sequence of a Propionibacterium acnes isolate from a sarcoidosis patient.2013
Author(s)
Minegishi K, Aikawa C, Furukawa A, Watanabe T, Nakano T, Ogura Y, Ohtsubo Y, Kurokawa K, Hayashi T, Maruyama F, Nakagawa I, Eishi Y
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Journal Title
Genome Announcement
Volume: 1
Issue: 1
Pages: 16-12
DOI
Related Report
Peer Reviewed
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