Association between atherosclerosis, cognitive impairment and masticatory dysfunction: Interaction of genetic factors

• Project/Area Number: 25293394
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Osaka University
• Principal Investigator: Maeda Yoshinobu 大阪大学, 歯学研究科(研究院), 教授 (10144510)
• Co-Investigator(Kenkyū-buntansha): IKEBE Kazunori 大阪大学, 大学院歯学研究科, 准教授 (70273696) ; KAGAWA Ryosuke 大阪大学, 歯学部附属病院, 医員 (40448147) ; OKADA Tadashi 大阪大学, 歯学部附属病院, 医員 (60733186) ; GONDO Yasuyuki 大阪大学, 人間科学研究科, 准教授 (40250196) ; KAMIDE Kei 大阪大学, 医学系研究科, 教授 (80393239)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000); Fiscal Year 2015: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000); Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
• Keywords: 高齢者歯科 / 咀嚼機能 / 循環器系疾患 / 認知機能 / 遺伝因子 / 歯学 / 歯数 / 高血圧 / 高齢者 / 動脈硬化 / 遺伝要因 / 口腔機能

Outline of Final Research Achievements

Our epidemiological study of community-dwelling old population showed that number of residual teeth and periodontal pocket depth were significantly associated with hypertension and cognitive function. Additionally, number of remaining teeth and periodontal pocket depth had significant associations with several SNPs related to cardiovascular diseases or dementia. Any general linear models with cardiovascular diseases or a cognitive decline as dependent variables didn’t showed a significant interaction between the genetic factor and oral status.
The results suggested common genetic factors between oral diseases and cardiovascular diseases or cognitive impairment.

Research Products

• [Journal Article] Association of occlusal force with cognition in independent older Japanese people (2016)
  • Author(s): 93)Takeshita H, Ikebe K, Gondo Y, Inagaki H, Masui Y, Inomata C, Mihara Y, Uota M, Matsuda K, Kamide K, Takahashi R, Arai Y, Maeda Y
  • Journal Title: JDR Clinical & Translational Research Volume: in press
  • Peer Reviewed
• [Journal Article] Influence of genetic and environmental factors on oral diseases and function in aged twins. (2015)
  • Author(s): Kurushima Y, Ikebe K, Matsuda K, Enoki K, Ogata S, Yamashita M, Murakami S, Hayakawa K, Maeda Y
  • Journal Title: J Oral Rehabil Volume: 42 Issue: 2 Pages: 49-56
  • DOI: 10.11607/ijp.4177
  • Peer Reviewed
• [Presentation] Association between lower occlusal force and slower walking speed mediated by less protein intake (2015)
  • Author(s): Ikebe K
  • Organizer: Gerontological Society of America
  • Place of Presentation: Orlando,USA
  • Year and Date: 2015-11-21
  • Int'l Joint Research / Invited
• [Presentation] Association between posterior occlusion and dietary intakes specific for atherosclerosis (2015)
  • Author(s): Tada S, Ikebe K, Inomata C, Takeshita H, Mihara Y, Uota M, Kamide K, Gondo Y, Oguro R, Nakama C, Masui Y, Ishizaki T, Arai Y, Shintani A, Maeda Y
  • Organizer: European college of gerodontology
  • Place of Presentation: Belfast,The United Kingdom
  • Year and Date: 2015-10-01
  • Int'l Joint Research
• [Presentation] Relationship between Oral Health and Arterial Sclerosis Using Older Twins. (2015)
  • Author(s): Kurushima Y, Ikebe K, Matsuda K, Enoki K, Ogata S, Yamashita M, Murakami S, Maeda Y.
  • Organizer: IADR
  • Place of Presentation: Boston
  • Year and Date: 2015-03-13
• [Presentation] 口腔の状態や機能は遺伝するのか？歯科分野での高齢双生児研究への取り組み (2014)
  • Author(s): 松田謙一，池邉一典，久留島悠子，榎木香織，三原佑介，前田芳信
  • Organizer: 日本補綴歯科学会関西・中四国合同支部会
  • Place of Presentation: 倉敷市
  • Year and Date: 2014-09-06