| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Outline of Final Research Achievements |
The correlations of FMISO-PET and FDG-PET with histological response to preoperative chemotherapy were assessed in patients with OSCC. This study enrolled 22 patients with OSCC undergoing preoperative chemotherapy. Each patient was evaluated by both FMISO-PET and FDG-PET before surgery, Good response was significantly more prevalent in patients with negative than positive FMISO uptake and without the hypoxic area evaluated by FMISO-PET TMR . An advantage of FMISO-PET over FDG-PET for predicting histological response to preoperative chemotherapy in patients with OSCC was observed.
The tumor uptake level of hypoxia-targeted PET tracers reflected the gene activation level by HRE, which eventually conferred the resistance to anti-cancer therapies on the tumor cells and tracer distribution of 18F-FMISO PET might be more suitable than that of 64Cu-ATSM PET for planning hypoxia-targeted radiotherapy.
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