Novel liver fluke species causing human illness in Ecuador: Prevalence, morphological and genetic identification, and infection sources
Project/Area Number |
25305011
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 海外学術 |
Research Field |
Parasitology (including sanitary zoology)
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Research Institution | National Institute of Infectious Diseases |
Principal Investigator |
Sugiyama Hiromu 国立感染症研究所, その他部局等, その他 (00145822)
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Co-Investigator(Kenkyū-buntansha) |
Kumazawa Hideo 高知大学, 医学部, 助教 (70127942)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2015: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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Keywords | 肝吸虫 / Amohimerus / 肺吸虫 / Paragonimus / エクアドル / 人獣共通感染症 / 食品媒介感染症 / 伝搬生態学 / Amphimerus / 人獣共通 / 食品媒介 / Paragoimus / 国際情報交換 / 国際研究者交流 |
Outline of Final Research Achievements |
The geographical distribution, prevalence, and intermediate hosts of the liver fluke belonging to the genus Amphimerus were investigated in Ecuador. Endemic areas were found in 3 provinces in the Pacific Coast. More than 20 species of the freshwater fish were examined for metacercariae. Small fishes called Guabina, which are highly prevalent in the small streams flowing along the villages, were found to be the most important sources of infection in humans. This fish species recorded a high number of metacercariae per fish. We analyzed the sequence of ribosomal ITS2 DNA from adult Amphimerus flukes discharged by patients after praziquantel treatment, and utilized it as a marker to identify the metacercariae of this species in fish. A literature review was also conducted on lung flukes to summarize the status of the disease, paragonimiasis caused by Paragonimus mexicanus.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] High prevalence of the liver fluke Amphimerus sp. in domestic cats and dogs in an area for human amphimeriasis in Ecuador2015
Author(s)
Calvopina, M., Cevallos, W., Atherton, R., Saunders, M., Small, A., Kumazawa, H., Sugiyama, H.
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Journal Title
PLoS Neglected Tropical Diseases
Volume: 10
Issue: 2
Pages: 1-9
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] High Prevalence of Infection of the Liver Fluke Amphimerus spp. in Domestic Cats and Dogs in an Area Endemic for Human Amphimeriasis in Ecuador2014
Author(s)
Calvopina, M., Cevallos, W., Atherton, R., Saunders, M., Small, A., Kumazawa, H., Sugiyama, H.
Organizer
The 13 th International Congress of Parasitology
Place of Presentation
Mexoico City, Mexico
Year and Date
2014-08-10 – 2014-08-15
Related Report
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