| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
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| Outline of Final Research Achievements |
In Sri Lanka in South Asia, chronic kidney disease has rapidly increased in the eastern part and the northern part of the island of Ceylon since the 1990s. We have investigated possible candidate agents and genetic factors. SLC13A3, KCNJ10 and LAMB2 were found to be possible candidates. Aristolochia has been used as a plant biologics with renal toxicity. In order to investigate the involvement, the urine was assayed for alistolochic acid. As a result, no detectable amount of the alistolochic acid was found. Also neonicotinoid was analyzed to reveal exposure to pesticide, while there was no difference between case and controls. And electron microscopic observations of the histological tissues were performed.The observation of electron microscopic observation of renal tissues showed no evidence supporting the heavy metal toxicity in the pathogenesis of CKDu .
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