Integrated molecular medicinal approach for rheumatic heart diseases in Central Asia.

• Project/Area Number: 25305032
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 海外学術
• Research Field: Infectious disease medicine
• Research Institution: Tokyo Medical University
• Principal Investigator: NAKAJIMA TOSHIHIRO 東京医科大学, 医学部, 教授 (90260752)
• Co-Investigator(Kenkyū-buntansha): KAWAHARA Koichi 大阪工業大学, 工学部, 教授 (10381170) ; NISHI Junichiro 鹿児島大学, 医歯学域医学系, 教授 (40295241) ; MIURA Naoki 鹿児島大学, 農水産獣医学域獣医学系, 准教授 (80508036)
• Research Collaborator: Omurzakova Nazgul A. The Kyrgyz National Center of Cardiology and Internal Medicine, Senior Research Assistant
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000); Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
• Keywords: キルギス / 溶連菌感染 / リウマチ熱 / フィールド調査 / 細菌学的検査 / 再興感染症 / 中央アジア / 超音波検査

Outline of Final Research Achievements

Infectious diseases, called by bacteria - Group A Streptococcus and its complications, among which Rheumatic fever/Rheumatic Heart Disease are now in outbreak in many developing countries, especially in the Republics of Central Asia. This situation causes sudden death of young generations and socio-economical damages in the countries of Central Asia. We have been studing over 2000 subjects in the Kyrgyz Republic, as experimental country of the Central Asian region) by using a rapid antigen detection test (RADT) to detect Group A Streptococus.Then subjects with positive test results (apprx. 400-500) underwent through bacteriological culture on nutrient media smears from the throat with further growth of the bacteria streptococcus culture.As a result, we have found the biomass might be one of the risk factors for multiple bacterial infections via dysregulation of mucosal immunity.

Research Products

• [Journal Article] Mitochondrial Ubiquitin Ligase Activator of NF-κB (MULAN) regulates NF-κB signaling in ER stress-stimulated cells. (2016)
  • Author(s): Fujita H, Aratani S, Fujii R, Yamano Y, Yagishita N, Araya N, Izumi T, Azakami K, Hasegawa D, Nishioka K and Nakajima T
  • Journal Title: Int J Mol Med. Volume: 37 Issue: 6 Pages: 1611-1618
  • DOI: 10.3892/ijmm.2016.2566
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Enteric lactoferrin attenuates the development of high-fat and high-cholesterol diet-induced hypercholesterolemia and atherosclerosis in Microminipigs. (2016)
  • Author(s): Morishita S, Kawaguchi H, Ono T, Miura N, Murakoshi M, Sugiyama K, Kato H, Tanimoto A, Nishino H.
  • Journal Title: Biosci Biotechnol Biochem. Volume: 80 Issue: 2 Pages: 295-303
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  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A bundle that includes active surveillance, contact precaution for carriers, and cefazolin-based antimicrobial prophylaxis prevents methicillin-resistant Staphylococcus aureus infections in clean orthopedic surgery. (2016)
  • Author(s): Kawamura H, Matsumoto K, Shigemi A, Orita M, Nakagawa A, Nozima S, Tominaga H, Setoguchi T, Komiya S, Tokuda K, Nishi J
  • Journal Title: Am J Infect Control Volume: 44 Issue: 2 Pages: 210-4
  • DOI: 10.1016/j.ajic.2015.09.014
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Epidemiological analysis of nosocomial MRSA outbreaks using phage open-reading frame typing in a tertiary-care hospital. (2016)
  • Author(s): Kawamura H, Tokuda K, Imuta N, Kubota T, Koriyama T, Miyanohara H, Hashiguchi T, Kawano Y, Nishi J.
  • Journal Title: Jpn J Infect Dis. Volume: in press
  • NAID: 130005284194
  • Peer Reviewed / Open Access
• [Journal Article] The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1β. (2015)
  • Author(s): Fujita H, Yagishita N, Aratani S, Saito-Fujita T, Morota S, Yamano Y, Hansson MJ, Inazu M, Kokuba H, Sudo K, Sato E, Kawahara K, Nakajima F, Hasegawa D, Higuchi I, Sato T, Araya N, Usui C, Nishioka K, Nakatani Y, Maruyama I, Usui M, Hara N, Uchino H, Elmer E, Nishioka K, Nakajima T.
  • Journal Title: EMBO J. Volume: 34 Issue: 8 Pages: 1042-55
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  • Peer Reviewed / Open Access
• [Journal Article] A natural therapeutic approach for the treatment of periodontitis by MK615. (2015)
  • Author(s): Yoko Morimoto-Yamashita, Yoshiko Kawakami, Syoko Tatsuyama, Keiko Miyashita, Makiko Emoto, Kiyoshi Kikuchi, Ko-ichi Kawahara, Masayuki Tokuda
  • Journal Title: Medical Hypotheses Volume: 85 Issue: 5 Pages: 618-621
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  • Peer Reviewed / Open Access
• [Journal Article] GM2 gangliosidosis variant 0 (Sandhoff disease) in a mixed-breed dog. (2015)
  • Author(s): Kohyama M, Yabuki A, Kawasaki Y, Kawaguchi H, Miura N, Kitano Y, Onitsuka T, Rahman MM, Miyoshi N, Yamato O.
  • Journal Title: J Am Anim Hosp Assoc Volume: 51 Issue: 6 Pages: 369-400
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  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Diagnostic imaging of intra-abdominal cyst in heifer using the computed tomography (2015)
  • Author(s): Otomaru, K., Fujikawa, T., Saito, Y., Ando, T., Obi, T., Miura, N., Kubota, C.
  • Journal Title: Journal of Veterinary Medical Science Volume: 77 Issue: 9 Pages: 1191-1193
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  • NAID: 130005100727
  • ISSN: 0916-7250, 1347-7439
  • Peer Reviewed / Open Access
• [Journal Article] Profiles of reproductive hormone in the microminipig during the normal estrous cycle. (2015)
  • Author(s): Noguchi, M., Miura, N., Ando, T., Kubota, C., Hobo, S., Kawaguchi, H., Tanimoto, A.
  • Journal Title: In Vivo. Volume: 29 Pages: 17-22
  • Peer Reviewed
• [Journal Article] Mogamulizumab, an anti-CCR4 antibody, targets human T-lymphotropic virus type 1-infected CD8+ and CD4+ T cells to treat associated myelopathy. (2015)
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  • Journal Title: J Infect Dis. Volume: 211 Issue: 2 Pages: 238-48
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  • Peer Reviewed / Open Access
• [Journal Article] Synoviolin inhibitor LS-102 reduces endoplasmic reticulum stress-induced collagen secretion in an in vitro model of stress-related interstitial pneumonia. (2015)
  • Author(s): Nakajima F, Aratani S, Fujita H, Yagishita N, Ichinose S, Makita K, Setoguchi Y, Nakajima T.
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• [Journal Article] Effects of xenon irradiation of the stellate ganglion region on fibromyalgia (2015)
  • Author(s): Nakajima F, Komoda A, Aratani S, Fujita H, Kawate M, Nakatani K, Akiyama M, Makita K, Nakajima T.
  • Journal Title: Journal of Physical Therapy Science Volume: 27 Issue: 1 Pages: 209-212
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  • NAID: 130004835113
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  • Peer Reviewed / Open Access
• [Journal Article] Profiles of reproductive hormone in the microminipig during the normal estrous cycle. (2015)
  • Author(s): Noguchi M, Miura N, Ando T, Kubota C, Hobo S, Kawaguchi H, Tanimoto A.
  • Journal Title: In Vivo Volume: 29 Pages: 17-22
  • Peer Reviewed
• [Journal Article] HTLV-1 induces a Th1-like state in CD4+CCR4+ T cells. (2014)
  • Author(s): Araya N, Sato T, Ando H, Tomaru U, Yoshida M, Coler-Reilly A, Yagishita N, Yamauchi J, Hasegawa A, Kannagi M, Hasegawa Y, Takahashi K, Kunitomo Y, Tanaka Y, Nakajima T, Nishioka K, Utsunomiya A, Jacobson S, Yamano Y.
  • Journal Title: J Clin Invest. Volume: 124 Issue: 8 Pages: 3431-42
  • DOI: 10.1172/jci75250
  • Peer Reviewed / Open Access
• [Journal Article] Multipotency of equine mesenchymal stem cells derived from synovial fluid. (2014)
  • Author(s): Murata D, Miyakoshi D, Hatazoe T, Miura N, Tokunaga S, Fujiki M, Nakayama K, Misumi K.
  • Journal Title: Vet J. Volume: 202 Issue: 1 Pages: 53-61
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  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Comparison of the Genomic Sequence of the Microminipig, a Novel Breed of Swine, with a Genomic Database for Conventional Pig. (2014)
  • Author(s): Miura N, Kucho K, Noguchi M, Miyoshi N, Uchiumi T, Kawaguchi H. Tanimoto A.
  • Journal Title: In Vivo. Volume: 28 Pages: 1107-1111
  • Peer Reviewed
• [Journal Article] Factors affecting treatment and recurrence of Clostridium difficile infections. (2014)
  • Author(s): Matsumoto K, Kanazawa N, Shigemi A, Ikawa K, Morikawa N, Koriyama T, Orita M, Kawamura H, Tokuda K, Nishi J, Takeda Y.
  • Journal Title: Biol Pharm Bull. Volume: 37 Pages: 1811-1815
  • NAID: 130004703902
  • Peer Reviewed
• [Journal Article] Characteristics of group B Streptococcus isolated from infants with invasive infections: a population-based study in Japan. (2014)
  • Author(s): Chang B, Wada A, Hosoya M, Oishi T, Ishiwada N, Oda M, Sato T, Terauchi Y, Okada K, Nishi J, Akeda H, Kamiya H, Ohnishi M, Ihara T. Japanese Invasive Disease Study Group.
  • Journal Title: Jpn J Infect Dis. Volume: 67 Pages: 356-360
  • NAID: 130004692234
  • Peer Reviewed / Open Access
• [Journal Article] 溶血性レンサ球菌感染症 (2014)
  • Author(s): 西 順一郎
  • Journal Title: 小児内科 増刊号 小児疾患診療のための病態生理1 改訂5版 Volume: 46 Pages: 815-819
• [Journal Article] 論壇 肺炎球菌ワクチンの効果と血清型変化への対応 (2014)
  • Author(s): 西 順一郎
  • Journal Title: 日本小児科医会会報 Volume: 48 Pages: 99-101
• [Journal Article] Upregulation of non-β Cell-derived Vascular Endothelial Growth FactorA Increases Small Clusters of Insulin producing Cells in the Pancreas. (2014)
  • Author(s): Takenouchi K, Shrestha B, Yamakuchi M, Yoshinaga M, Arimura N, Kawaguchi H, Nagasato T, Feil R, Kawahara K-I, Sakamoto T, Maruyama I, Hashiguchi T.
  • Journal Title: Experimental and Clinical Endocrinology & Diabetes Volume: in press Issue: 05 Pages: 308-15
  • DOI: 10.1055/s-0034-1371811
  • Peer Reviewed / Open Access
• [Journal Article] HMGB1 promotes the development of pulmonary arterial hypertension in rats. (2014)
  • Author(s): Sadamura-Takenaka Y, Ito T, Noma S, Oyama Y, Yamada S, Kawahara K, Inoue H, Maruyama I.
  • Journal Title: PLoS One. Volume: 9 Issue: 7 Pages: e102482-e102482
  • DOI: 10.1371/journal.pone.0102482
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Thymidine phosphorylase regulates the expression of CXCL10 in rheumatoid arthritis fibroblast-like synoviocytes (2014)
  • Author(s): Toyoda Y, Tabata S, Kishi J, Kuramoto T, Mitsuhashi A, Saijo A, Kawano H, Goto H, Aono Y, Hanibuchi M, Horikawa H, Nakajima T, Furukawa T, Sone S, Akiyama S, Nishioka Y
  • Journal Title: Arthritis & Rheumatology Volume: 66(3) Issue: 3 Pages: 560-568
  • DOI: 10.1002/art.38263
  • Peer Reviewed / Open Access
• [Journal Article] Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis. (2014)
  • Author(s): Wu T, Zhao F, Gao B, Tan C, Yagishita N, Nakajima T, Wong PK, Chapman E, Fang D, Zhang DD.
  • Journal Title: Genes Dev Volume: 28(7) Issue: 7 Pages: 708-722
  • DOI: 10.1101/gad.238246.114
  • Peer Reviewed / Open Access
• [Journal Article] Hyporesponsiveness to the infecting serotype after vaccination of children with seven-valent pneumococcal conjugate vaccine following invasive pneumococcal disease. (2014)
  • Author(s): Tamura K., Matsubara K., Ishiwada N., Nishi J., Ohnishi H., Suga S., Ihara T., Chang B., Akeda Y., Oishi K., Japanese I. P. D. Study Group.
  • Journal Title: Vaccine. Volume: 32(13) Issue: 13 Pages: 1444-1450
  • DOI: 10.1016/j.vaccine.2014.01.031
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• [Journal Article] 嚢胞性線維症の2幼児例. (2014)
  • Author(s): 柳元孝介, 西 順一郎, 田中主美, 山元公恵, 丸山慎介, 石黒 洋, 河野嘉文.
  • Journal Title: 日本小児呼吸器学会雑誌 Volume: 24(2) Pages: 132-137
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• [Journal Article] 特集／消化管感染症・最近の話題 サルモネラ感染症 (2014)
  • Author(s): 西 順一郎．
  • Journal Title: 小児内科 Volume: 46(1) Pages: 63-68
• [Journal Article] Rapid Development of Atherosclerosis in the World's Smallest Microminipig Fed a High-Fat/High-Cholesterol Diet. (2014)
  • Author(s): Kawaguchi, H., Yamada, T., Miura, N., Ayaori, M., Uto-Kondo, H., Ikegawa, M., Noguchi, M., Wang, K.Y., Izumi, H., Tanimoto, A.
  • Journal Title: J Atheroscler Thromb Volume: 21(3) Pages: 186-203
  • Peer Reviewed
• [Journal Article] Investigation of necessity of sodium cholate and minimal required amount of cholesterol for dietary induction of atherosclerosis in microminipigs. (2014)
  • Author(s): Akioka, K., Kawaguchi, H., Kitajima, S., Miura, N., Noguchi, M., Horiuchi, M., Miyoshi, N., Tanimoto, A.
  • Journal Title: In Vivo Volume: 28(1) Pages: 81-90
  • Peer Reviewed
• [Journal Article] Comparative evaluation of direct thrombin and factor Xa inhibitors with antiplatelet agents under flow and static conditions: an in vitro flow chamber model. (2014)
  • Author(s): Hosokawa, K., Ohnishi, T., Sameshima, H., Miura, N., Koide, T., Maruyama, I., Tanaka, K.A.
  • Journal Title: PLoS One Volume: 9(1)
  • Peer Reviewed
• [Journal Article] Antithrombotic effects of PAR1 and PAR4 antagonists evaluated under flow and static conditions. (2014)
  • Author(s): Hosokawa, K., Ohnishi, T., Miura, N., Sameshima, H., Koide, T., Tanaka, K.A., Maruyama, I.
  • Journal Title: Thromb Res. Volume: 133(1) Pages: 66-72
  • Peer Reviewed
• [Journal Article] Ganglion cysts arising from a canine stifle joint. (2014)
  • Author(s): Murata, D., Sogawa, T., Tokunaga, S., Iwanaga, T., Kawaguchi, H., Miyoshi, N., Momoi, Y., Fujiki, M., Miura, N.
  • Journal Title: J Vet Med Sci. Volume: 76(3) Pages: 457-9
  • NAID: 130003382384
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• [Journal Article] Positive feedback loop via astrocytes causes chronic inflammation in virus-associated myelopathy. (2013)
  • Author(s): Ando H., Sato T., Tomaru U., Yoshida M., Utsunomiya A., Yamauchi J., Araya N., Yagishita N., Coler-Reilly A., Shimizu Y., Yudoh K., Hasegawa Y., Nishioka K., Nakajima T., Jacobson S., Yamano Y.
  • Journal Title: Brain Volume: 136(Pt9) Issue: 9 Pages: 2876-2887
  • DOI: 10.1093/brain/awt183
  • Peer Reviewed
• [Journal Article] CSF CXCL10, CXCL9, and Neopterin as Candidate Prognostic Biomarkers for HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. (2013)
  • Author(s): Sato T., Coler-Reilly A., Utsunomiya A., Araya N., Yagishita N., Ando H., Yamauchi J., Inoue E., Ueno T., Hasegawa Y., Nishioka K., Nakajima T., Jacobson S., Izumo S., Yamano Y.
  • Journal Title: PLoS Negl Trop Dis Volume: 7(10) Issue: 10 Pages: e2479-e2479
  • DOI: 10.1371/journal.pntd.0002479
  • Peer Reviewed
• [Journal Article] Vulnerability to traumatic stress in fibromyalgia patients : 19 months follow-up after the Great East Japan Disaster (2013)
  • Author(s): Usui C, Hatta K, Aratani S, Yagishita N, Nishioka K, Itoh K, Yamano Y, Nakamura H, Asukai N, Nakajima T, Nishioka K
  • Journal Title: Arthritis Research & Therapy Volume: 15(5) Issue: 5
  • DOI: 10.1186/ar4310
  • Peer Reviewed
• [Journal Article] Low opsonic activity to the infecting serotype in pediatric patients with invasive pneumococcal disease (2013)
  • Author(s): Oishi T, Ishiwada N, Matsubara K, Nishi J, Chang B, Tamura K, Akeda Y, Ihara T, Nahm MH, Oishi K; ｔhe Japanese IPD Study Group
  • Journal Title: Vaccine Volume: 31（5） Issue: 5 Pages: 845-849
  • DOI: 10.1016/j.vaccine.2012.11.010
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• [Journal Article] Prospective safety monitoring of Haemophilus influenzae type b and heptavalent pneumococcal conjugate vaccines in Kagoshima, Japan. (2013)
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  • NAID: 130003381678
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• [Journal Article] Ramsay Hunt syndrome in a girl with acute lymphoblastic leukemia during maintenance therapy (2013)
  • Author(s): Kodama Y, Okamoto Y, Nishi J, Hashiguchi S, Yamaki Y, Kurauchi K, Tanabe T, Shinkoda Y, Nishikawa T, Suda Y, Kawano Y
  • Journal Title: J Pediatr Hematol Oncol Volume: 35 Issue: 5 Pages: 224-225
  • DOI: 10.1097/mph.0b013e3182830d30
  • Peer Reviewed
• [Journal Article] Antimicrobial effect of an ultrasonic levitation washer disinfector with silver electrolysis and ozone oxidation on methicillin-resistant Staphylococcus aureus (MRSA). (2013)
  • Author(s): Tamai M, Matsushita S, Miyanohara H, Imuta N, Ikeda R, Kawai K, Nishi J, Sakamoto A, Shigihara T, Kanekura T.
  • Journal Title: J Dermatol Volume: 40(12) Issue: 12 Pages: 1020-1026
  • DOI: 10.1111/1346-8138.12327
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• [Journal Article] 最新の小児科処置 血液培養 (2013)
  • Author(s): 西 順一郎．
  • Journal Title: 小児内科 Volume: 45(4) Pages: 684-686
• [Journal Article] 予防接種法改正―予防接種とワクチンの現状を知る― Hib（ヘモフィルス・インフルエンザ菌ｂ型） (2013)
  • Author(s): 西 順一郎．
  • Journal Title: 小児科 Volume: 54(12)（11月増大号） Pages: 1709-1714
• [Journal Article] 侵襲性肺炎球菌感染症とワクチンによる予防． (2013)
  • Author(s): 西 順一郎．
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• [Journal Article] Recombinant thrombomodulin protects mice against histone-induced lethal thromboembolism. (2013)
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• [Journal Article] Potential of the angiotensin receptor blockers (ARBs) telmisartan, Irbesartan, and candesartan for inhibiting the HMGB1/RAGE axis in prevention and acute treatment of stroke. (2013)
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• [Journal Article] Saturated fatty acid palmitate induces extracellular release of histone H3: a possible mechanistic basis for high-fat diet-induced inflammation and thrombosis. (2013)
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• [Journal Article] Immunohistochemical expression of thrombomodulin in vestibular schwannoma (2013)
  • Author(s): Yamahata H, Yunoue S, Tokimura H, Hanaya R, Hirano H, Tokudome M, Karki P, Yonezawa H, Sugata S, Kawahara K, Maruyama I, Arita K
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• [Journal Article] Generalized Alopecia with Vasculitis-Like Changes in a Dog with Babesiosis. (2013)
  • Author(s): Tasaki, Y., Miura, N., Iyori, K., Nishifuji, K., Endo, Y., Momoi, Y.
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  • NAID: 130003362212
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• [Journal Article] Sex Differences in Serum Lipid Profile in Novel Microminipigs. (2013)
  • Author(s): Kawaguchi, H., Yamada, T., Miura, N., Noguchi, M., Izumi, H., Miyoshi, N., Tanimoto, A..
  • Journal Title: In Vivo. Volume: 27(5) Pages: 617-621
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• [Journal Article] Cross-Reactivity of the Anti-Human D-Dimer Monoclonal Antibody 1C9-6F10 to Canine Fibrin Degradation Products. (2013)
  • Author(s): Miura, N., Furukawa, M., Magari, Y., Momoi, Y.
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  • NAID: 130003362135
  • Peer Reviewed
• [Journal Article] The Japanese version of the 2010 American College of Rheumatology Preliminary Diagnostic Criteria for Fibromyalgia and the Fibromyalgia Symptom Scale : reliability and validity (2012)
  • Author(s): 臼井千恵、中島利博, 他9名
  • Journal Title: Mod.Rheumatol. Volume: 20 Issue: 1 Pages: 40-44
  • DOI: 10.1007/s10165-011-0462-3
  • NAID: 10030206754
  • Peer Reviewed
• [Presentation] 膵炎と肺高血圧症を併発した犬の全血血栓形成観測システムによる血小板＆凝固能検査の可能性 (2015)
  • Author(s): 岩永朋子、福島隆治、山田修作、平尾大樹、永里朋香、丸山征郎、三浦直樹
  • Organizer: 第103回日本獣医循環器学会
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2015-12-19
• [Presentation] T-TASを用いたイヌの心房細動時における急性期の血液凝固能の評価 (2015)
  • Author(s): 山田修作、平尾大樹、河口貴恵、和田智樹、島田香寿美、丹野耕作、永里朋香、丸山征郎、岩永朋子、三浦直樹、福島隆治
  • Organizer: 第103回日本獣医循環器学会
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2015-12-19
• [Presentation] 全血血栓形成観測システムT-TASを用いた心房細動モデル犬の心房血および末梢血における血栓形成能の刑事的変化 (2015)
  • Author(s): 平尾大樹、山田修作、河口貴恵、和田智樹、島田香寿美、丹野耕作、永里朋香、丸山征郎、三浦直樹、岩永朋子、福島隆治
  • Organizer: 第103回日本獣医循環器学会
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2015-12-19
• [Presentation] 細胞外ヒストンにおけるIL-1β放出機構の解明 (2015)
  • Author(s): 大池 加恵 勝野 涼太, 藤本 靖真, 安田 哲, 丸山 征郎, 川原 幸一
  • Organizer: 第３８回日本分子生物学会年会第８８回生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
• [Presentation] About prospects and future plans of the Kyrgyz - Japan cooperation in rheumatic feve (2015)
  • Author(s): Nakajima T
  • Organizer: OPENING CEREMONY OF KYRGYZ - JAPAN RESEARCH CENTER
  • Place of Presentation: Conference Hall of Ak-Keme hotel, Bishkek, Kyrgyz Republic
  • Year and Date: 2015-10-10
• [Presentation] 細胞外ヒストンによる炎症性サイトカインIL-1b放出機構の解明 (2015)
  • Author(s): 大池加恵、勝野涼太、藤本靖真、安田哲、丸山征郎、菊池清志、川原幸一
  • Organizer: 第６６回西日本生理学会
  • Place of Presentation: 久留米
  • Year and Date: 2015-10-09
• [Presentation] Decade of Kyrgyz - Japanese cooperation: the mission against the chronic rheumatic heart diseases - past, present and future. (2015)
  • Author(s): Nakajima T
  • Organizer: KYRGYZ NATIONAL CONGRESS OF RESPIRATORY AND ALLERGIC DISEASES/
  • Place of Presentation: Conference Hall of Ak-Keme hotel, Bishkek, Kyrgyz Republic
  • Year and Date: 2015-10-08
  • Int'l Joint Research / Invited
• [Presentation] Streptococcal infection and rheumatic fever in Kyrgyzstan. (2015)
  • Author(s): Omurzakov N
  • Organizer: KYRGYZ NATIONAL CONGRESS OF RESPIRATORY AND ALLERGIC DISEASES/
  • Place of Presentation: Conference Hall of Ak-Keme hotel, Bishkek, Kyrgyz Republic
  • Year and Date: 2015-10-08
  • Int'l Joint Research / Invited
• [Presentation] The detection of methicillin-sensitive Staphylococcus aureus from ulcer is a risk factor of amputation in foot infection with critical limb ischemia after revascularization. (2015)
  • Author(s): Kawamura H, Arata K, Imagama I, Koriyama T, Kojyo T, Shigemi A, Tokuda K, Imoto Y, Nishi J.
  • Organizer: The Infectious Diseases Society of America (IDSA)IDWeek 2015
  • Place of Presentation: Philadelphia,USA
  • Year and Date: 2015-10-07
  • Int'l Joint Research
• [Presentation] 低酸素培養条件下の犬リンパ腫細胞における生物学的活性の解析 (2015)
  • Author(s): 山崎裕毅、Lai Yu-Chang、瀬戸口明日香、越野裕子、中市統三、辻本 元、三浦直樹
  • Organizer: 第158回日本獣医学会
  • Place of Presentation: 北里大学獣医学部
  • Year and Date: 2015-09-07
• [Presentation] 縦隔型T細胞性リンパ腫を呈した若齢犬の1例 (2015)
  • Author(s): 山崎裕毅、川畑貴裕、澤真理子、Lai Yu-Chang、矢吹映、三浦直樹、桃井康行
  • Organizer: 第13回日本獣医がん学会
  • Place of Presentation: 東京コンベンションホール
  • Year and Date: 2015-07-04
• [Presentation] キルギス共和国における溶連菌感染症ならびにその合併症であるリウマチ性心疾患/リウマチ熱の現状―9年間のフィールド調査について―Study of Rheumatic Fever /Rheumatic Heart Diseases in Kyrgyz Republic (2015)
  • Author(s): Omurzakov N、三浦 直樹、川原 幸一、西 順一郎、八木下 尚子, 荒谷 聡子、中島利博
  • Organizer: 海外学術調査フェスタ
  • Place of Presentation: 東京外国語大学
  • Year and Date: 2015-06-27
• [Presentation] Genetic heterogeneity of AggR-positive enteroaggregative Escherichia coli (EAEC); emergence of EAEC/UPEC O25:H4:ST131 producing ESBL. (2015)
  • Author(s): Imuta N, Ooka T, Seto K, Yoshiie K, Nishi J.
  • Organizer: The 115th General Meeting of the American Society for Microbiology,
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2015-06-01
  • Int'l Joint Research
• [Presentation] 牛馬のCT及びMRI検査 (2015)
  • Author(s): 三浦直樹
  • Organizer: 平成26年度 日本獣医師会獣医学術学会年次大会
  • Place of Presentation: 岡山
  • Year and Date: 2015-02-13 – 2015-02-15
• [Presentation] 各疾患におけるD-dimerの臨床応用と検討 (2014)
  • Author(s): 3.宮本 早紀子、西口明博、飯倉 陵、杉山大輔、曲 泰男、伊藤 源太、三浦 直樹、桃井 康行
  • Organizer: 第３５回動物臨床医学会記念年次大会
  • Place of Presentation: 大阪
  • Year and Date: 2014-11-14 – 2014-11-16
• [Presentation] Notable Serotype Replacement of Invasive Streptococcus pneumoniae in Kagoshima, Japan, after the Sequential Introduction of 7-valent and 13-valent Pneumococcal Conjugate Vaccines (2014)
  • Author(s): Nishi J, Tokuda K, Imuta N, Chang B
  • Organizer: IDWeek 2014 Meeting of the Infectious Diseases Society of America
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2014-10-08 – 2014-10-12
• [Presentation] New aspect of Protein degradation in locomotive syndrome and metabolic disorders (2014)
  • Author(s): Nakajima T
  • Organizer: THE 2nd BIO RHEUMATOLOGY INTERNATIONAL CONGRESS
  • Place of Presentation: Moscow, Russia
  • Year and Date: 2014-06-05 – 2014-06-07
  • Invited
• [Presentation] Prevalence of Group A b-hemolytic Streptococcus and Clinical-Functional Peculiarities Assessment of Rheumatic Fever in the Kyrgyz Republic. (2014)
  • Author(s): Omurzakov N
  • Organizer: THE 2nd BIO RHEUMATOLOGY INTERNATIONAL CONGRESS
  • Place of Presentation: Moscow, Russia
  • Year and Date: 2014-06-05 – 2014-06-07
  • Invited
• [Presentation] Molecular epidemiological analysis of extended-spectrum beta-lactamase (ESBL)-producing enteroaggregative Escherichia coli (EAEC) (2014)
  • Author(s): Nishi J, Imuta N, Tokuda K, Yoshiie K
  • Organizer: The 114th General Meeting of the American Society for Microbiology
  • Place of Presentation: Boston, USA
  • Year and Date: 2014-05-17 – 2014-05-20
• [Presentation] Kyrgyz-Japan International scientific and practical expedition in the high valley (2014)
  • Author(s): Omurzakov N, Jumagulova A, Nakajima T
  • Organizer: World Congress of Cardiology Scientific Sessions 2014
  • Place of Presentation: Melbourne, Australia
  • Year and Date: 2014-05-04 – 2014-05-07
• [Presentation] Study about prevalence of group A streptococcus and clinical-functional assessment of rheumatic fever in Kyrgyz Republic. (2014)
  • Author(s): Omurzakov N, Nakajima T
  • Organizer: World Congress of Cardiology Scientific Sessions 2014
  • Place of Presentation: Melbourne, Australia
  • Year and Date: 2014-05-04 – 2014-05-07
• [Presentation] MRSAによるSSI発生による病院経営への影響について (2014)
  • Author(s): 折田美千代、川村英樹、松元一明、茂見茜里、郡山泰豊、西 順一郎．
  • Organizer: 第29回日本環境感染学会総会
  • Place of Presentation: 東京
• [Presentation] 感染防止加算連携施設でのアウトブレイク事例に対する訪問ラウンドと２次感染防止策 (2014)
  • Author(s): 折田美千代、川村英樹、松元一明、茂見茜里、郡山泰豊、西 順一郎．
  • Organizer: 第29回日本環境感染学会総会
  • Place of Presentation: 東京
• [Presentation] 全県下で毎年実施している医療関連感染対策アンケート結果－2011～2013年の推移－ (2014)
  • Author(s): 西 順一郎、渡邊真裕子、藺牟田直子、川村英樹、折田美千代、水間良裕、川原元司、吉永正夫、波多江正紀．
  • Organizer: 第29回日本環境感染学会総会
  • Place of Presentation: 東京
• [Presentation] 積極的監視培養と接触予防策遵守を中心とした整形外科領域MRSA手術部位感染対策の効果． (2014)
  • Author(s): 川村英樹、茂見茜里、折田美千代、中川 彩、郡山豊泰、松元一明、西 順一郎．
  • Organizer: 第29回日本環境感染学会総会
  • Place of Presentation: 東京
• [Presentation] 感染防止対策加算連携施設における低濃度酸化エチレンガス（EOG）供給により発生した衛生材料滅菌不良発生事例への支援． (2014)
  • Author(s): 取附和成、折田美千代、川村英樹、西 順一郎．
  • Organizer: 第29回日本環境感染学会総会
  • Place of Presentation: 東京
• [Presentation] 腸管凝集性大腸菌(EAEC) O25:H4 への薬剤耐性遺伝子およびAggR遺伝子の移行 (2014)
  • Author(s): 12. 吉家清貴、藺牟田直子、西 順一郎．
  • Organizer: 第87回日本細菌学会総会
  • Place of Presentation: 東京
• [Presentation] Molecular epidemiology analysis of extend-spectrum-βlactamase (ESBL) producing Enteroaggregaive Escherichia coli (EAEC) (2014)
  • Author(s): 13. Imuta N, Ooka T, Ogura Y, Hayashi T, Nishi J.
  • Organizer: 第87回日本細菌学会総会
  • Place of Presentation: 東京
• [Presentation] 心筋梗塞が疑われたイヌの１例． (2014)
  • Author(s): 岩永朋子、遠藤昭子、福島隆治、宮原健吉、永里朋香、丸山征郎、三浦直樹．
  • Organizer: 日本獣医内科アカデミー 第10回記念学術大会
  • Place of Presentation: 横浜
• [Presentation] ドキソルビシンを使用した犬におけるトロポニンTの評価． (2014)
  • Author(s): 宮本早紀子 岩永朋子 下川孝子 瀬戸口明日香 遠藤泰之 桃井康行 三浦直樹．
  • Organizer: 日本獣医内科アカデミー 第10回記念学術大会．
  • Place of Presentation: 横浜
• [Presentation] 滑膜炎関連因子SPACIA1によるCDK6の遺伝子発現調節機構の解析 (2013)
  • Author(s): 小松梨恵、藤井亮爾、佐藤知雄、山野嘉久、遊道和雄、別府諸兄、西岡久寿樹、中島利博
  • Organizer: 第57回日本リウマチ学会 総会・学術集会
  • Place of Presentation: 京都
• [Presentation] Synoviolin rheumatoid arthritis to metabolic disorders. (2013)
  • Author(s): Nakajima T, Fujita H, Aratani S, Yagishita N
  • Organizer: 5th Annual Ubiquitin Drug Discovery & Diagnostics Conference 2013
  • Place of Presentation: Philadelphia, USA
• [Presentation] Synoviolin inhabitors have anti-obesity activity. (2013)
  • Author(s): Aratani S, Fujita H, Yagishita N, Nishioka K, Nakajima T
  • Organizer: 5th Annual Ubiquitin Drug Discovery & Diagnostics Conference 2013
  • Place of Presentation: Philadelphia, USA
• [Presentation] The role of Synovioloin in weight control. (2013)
  • Author(s): Fujita H, Yagishita N, Aratani S, Nishioka K, Nakajima T
  • Organizer: 5th Annual Ubiquitin Drug Discovery & Diagnostics Conference 2013
  • Place of Presentation: Philadelphia, USA
• [Presentation] 東京医科大学－霞が関アーバンクリニック－高知だいいちリハビリテーション病院を中心とした線維筋痛症のプラットフォームの構築とその成果 (2013)
  • Author(s): 中島利博
  • Organizer: 日本線維筋痛症学会 第 5 回学術集会
  • Place of Presentation: 神奈川
  • Invited
• [Presentation] 線維筋痛症患者に対する星状神経節近傍キセノン光治療の効果 (2013)
  • Author(s): 中島若巳、薦田昭宏、澁谷美雪、河手眞理子、中谷孝、槇田浩史、中島利博
  • Organizer: 日本線維筋痛症学会 第 5 回学術集会
  • Place of Presentation: 神奈川
• [Presentation] 線維筋痛症の歩行障害について (2013)
  • Author(s): 薦田昭宏、窪内郁恵、橋本聡子、中島若巳、堤克義、梅原由香里、澁谷美雪、岡村聡子、中谷孝、中島利博
  • Organizer: 日本線維筋痛症学会 第 5 回学術集会
  • Place of Presentation: 神奈川
• [Presentation] FM患者における抗電位依存性K+チャネル（VGKC）複合体抗体の高い陽性率 (2013)
  • Author(s): 山野嘉久、渡邊修、西岡健弥、臼井千恵、長田賢一、荒谷聡子、藤田英俊、八木下尚子、伊藤健司、中村郁朗、岡寛、中島利博、西岡久寿樹
  • Organizer: 日本線維筋痛症学会 第 5 回学術集会
  • Place of Presentation: 神奈川
• [Presentation] 抗疼痛薬による肥満と小胞体ストレスの関与 (2013)
  • Author(s): 荒谷聡子、臼井千恵、山野嘉久、西岡健弥、藤田英俊、八木下尚子、伊藤健司、長田賢一、中村郁朗、西岡久寿樹、中島利博
  • Organizer: 日本線維筋痛症学会 第 5 回学術集会
  • Place of Presentation: 神奈川
• [Presentation] 線維筋痛症における関節超音波所見と疾患活動性の検討 (2013)
  • Author(s): 西森美佐子、尾崎鈴子、梅原由加里、岡村聡子、澁谷美雪、荒谷聡子、中島若巳、堤克嘉、上村致信、中谷孝、中島利博
  • Organizer: 日本線維筋痛症学会 第 5 回学術集会
  • Place of Presentation: 神奈川
• [Presentation] 線維筋痛症に対する治療（医学的介入）効果について (2013)
  • Author(s): 岡村聡子、島津央、薦田昭宏、西森美佐子、梅原由加里、澤井健、 澁谷美雪、中島若巳、堤克嘉、上村致信、中谷孝、中島利博
  • Organizer: 日本線維筋痛症学会 第 5 回学術集会
  • Place of Presentation: 神奈川
• [Presentation] Prevalence of Group A b-hemolytic streptococcus and clinicalfunctional funcational peculiarities assessment of rheumatic fever in the Kyrgyz republic. (2013)
  • Author(s): Omurzakov N, Djumagulova A, Nakajima T
  • Organizer: Symposium of the Asia Pacific League of Associations for Rheumatology in conjunction with 2nd Indonesia-Japan Rheumatology Forum (IJREF)
  • Place of Presentation: Bali, Indonesia
• [Presentation] Effects of Care Bundle for Preventing Orthopedic Methicillin-resistant Staphylococcus aureus (MRSA) Surgical Site Infections (SSI). (2013)
  • Author(s): Kawamura H, Shigemi A, Koriyama T, Matsumoto K, Orita M, Komiya S, Tokuda K, Nishi J.
  • Organizer: IDWeek 2013, A joint meeting of IDSA, SHEA, HIVMA, and PIDS
  • Place of Presentation: San Francisco
• [Presentation] MRSA感染症アウトブレイク疑い事例におけるPOT法とPFGE法による遺伝子タイピングの比較 (2013)
  • Author(s): 川村英樹、藺牟田直子、徳田浩一、郡山豊泰、松元一明、茂見茜里、西 順一郎．
  • Organizer: 第87回日本感染症学会学術講演会
  • Place of Presentation: 横浜
• [Presentation] 紹介型二次病院における21年間のサルモネラ腸炎とカンピロバクター腸炎の検討． (2013)
  • Author(s): 山元公恵，鮫島幸二，西 順一郎．
  • Organizer: 第45回日本小児感染症学会総会・学術集会
  • Place of Presentation: 札幌
• [Presentation] 鹿児島県における小児侵襲性GBS感染症 －遅発型・超遅発型の4例－ (2013)
  • Author(s): 渡邉健二，山遠 剛，常 彬，藺牟田直子，柳元孝介，鮫島幸二，西 順一郎．
  • Organizer: 第45回日本小児感染症学会総会・学術集会
  • Place of Presentation: 札幌
• [Presentation] ESBL産生尿路病原性大腸菌O25:H4への腸管凝集性大腸菌病原遺伝子の水平伝播 (2013)
  • Author(s): 藺牟田直子，西 順一郎．
  • Organizer: 第45回日本小児感染症学会総会・学術集会
  • Place of Presentation: 札幌
• [Presentation] 若年性特発性関節炎治療中に間質性肺炎を発症した11歳女児症例． (2013)
  • Author(s): 久保田知洋、山遠 剛、西 順一郎、武井修治、河野嘉文．
  • Organizer: 第46回日本小児呼吸器学会
  • Place of Presentation: 佐賀
• [Presentation] 乳房炎の診断マーカーとしてのmicroRNAの発現解析の可能性． (2013)
  • Author(s): 三浦直樹、前村 忠、鎌田 立、村田 望、北原豪、桃井康行．
  • Organizer: 第156回 日本獣医学会学術集会．
  • Place of Presentation: 岐阜
• [Presentation] B細胞特異的VEGF-A過剰発現マウスのリンパ組織の構造変化、免疫応答と脾臓のトランスクリプトーム（mRNA&microRNA）解析． (2013)
  • Author(s): 鈴木雄大、三浦直樹、ビニタ スレスタ、伊藤隆史、竹之内和則、山口宗一、桃井康行、橋口照人．
  • Organizer: 第156回 日本獣医学会学術集会．
  • Place of Presentation: 岐阜
• [Presentation] 乳腺腫瘍罹患犬の血清microRNA解析． (2013)
  • Author(s): 片野田祐介、前村忠、川口博明、伊藤敏生、花野みなみ、岩永朋子、三好宣彰、桃井康行、三浦直樹．
  • Organizer: 第156回 日本獣医学会学術集会．
  • Place of Presentation: 岐阜
• [Presentation] 血流下における血小板血栓形成能を指標とした抗血小板薬抵抗性の解析． (2013)
  • Author(s): 三浦直樹、大西朋子、鮫島寿代、長谷川喬彬、永里朋香、細川和也、伊藤隆史、小出武比古、丸山征郎．
  • Organizer: 第35回日本血栓止血学会学術集会．
  • Place of Presentation: 山形
• [Presentation] E3ユビキチンリガーゼであるシノビオリンによる体重制御機構
  • Author(s): 藤田英俊、荒谷聡子、中島若巳、西岡久寿樹、中島利博、諸田沙織、内野博之、須藤カツ子
  • Organizer: 第172回東京医科大学医学会総会
  • Place of Presentation: 東京
• [Presentation] シノビオリンによる新規エネルギー代謝制御機構
  • Author(s): 藤田英俊、八木下尚子、荒谷聡子、西岡久寿樹、中島利博
  • Organizer: 第90回東京医科大学・東京薬科大学・免疫アレルギー研究会
  • Place of Presentation: 東京
• [Presentation] シノビオリンを中心とした変異型肺サーファクタント蛋白Cによる間質性肺炎の分子病態モデル
  • Author(s): 中島若巳、荒谷聡子、藤田英俊、西岡久寿樹、槇田浩史、瀬戸口靖弘、中島利博
  • Organizer: 日本肺サーファクタント・界面医学会 第49回学術研究会
  • Place of Presentation: 東京
• [Presentation] 新規タンパク質・脂質の共役的分解経路の発見と創薬開発への展開－ロコモーティブ症候群とメタボリック症候群の新たなる接点－
  • Author(s): 中島利博
  • Organizer: 第3回医薬工3大学包括連携推進シンポジウム
  • Place of Presentation: 東京
  • Invited
• [Presentation] シノビオリンによる新規エネルギー代謝制御機構の発見
  • Author(s): 藤田英俊、荒谷聡子、八木下尚子、諸田沙織、内野博之、稲津正人、臼井正彦、西岡久寿樹、中島利博
  • Organizer: 第3回医薬工3大学包括連携推進シンポジウム
  • Place of Presentation: 東京
• [Presentation] リウマチと肥満を標的としたシノビオリン阻害剤の創薬開発研究の展開
  • Author(s): 荒谷聡子、藤田英俊、八木下尚子、西岡久寿樹、中島利博
  • Organizer: 第3回医薬工3大学包括連携推進シンポジウム
  • Place of Presentation: 東京
• [Presentation] サーファクタントタンパク質ＳＰ－Ｃの遺伝子変異をモデルとした肺線維症発症の分子機序へのアプローチ
  • Author(s): 中島若巳、荒谷聡子、藤田英俊、槇田浩史、西岡久寿樹、瀬戸口靖弘、中島利博
  • Organizer: 第3回医薬工3大学包括連携推進シンポジウム
  • Place of Presentation: 東京
• [Book] リウマチをなおす 攻めの治療 チーム医療と新薬 (2014)
  • Author(s): 中島 利博
  • Total Pages: 110
  • Publisher: 出版芸術社
• [Remarks] 東京医科大学医学総合研究所運動器科学研究部門
  • URL: http://toshinakajima2014.wix.com/tokyomed
• [Remarks] シルクロードの健康的な未来を考える会
  • URL: http://riumachinetsu.org/movement/index.html
• [Remarks] 鹿児島大学大学院医歯学総合研究科 微生物学分野
  • URL: http://www.kufm.kagoshima-u.ac.jp/~bacterio/index.html
• [Remarks] 東京医科大学 医学総合研究所 運動器科学研究部門
  • URL: http://toshinakajima2014.wix.com/tokyomed