Molecular patho-epidemiological study on the etiological background for oral superficial carcinoma among Asian ethnic groups
Project/Area Number |
25305035
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 海外学術 |
Research Field |
Morphological basic dentistry
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Research Institution | Niigata University |
Principal Investigator |
CHENG Jun 新潟大学, 医歯学系, 准教授 (40207460)
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Co-Investigator(Kenkyū-buntansha) |
丸山 智 新潟大学, 医歯学総合病院, 講師 (30397161)
山崎 学 新潟大学, 医歯学系, 助教 (10547516)
阿部 達也 新潟大学, 医歯学総合病院, 医員 (70634856)
朔 敬 新潟大学, 医歯学系, 教授 (40145264)
|
Project Period (FY) |
2013-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
|
Keywords | 病理学 / 口腔癌 / アジア民族 / 口腔粘膜表在性癌 / 分子病理疫学 / 口腔ガン / 口腔表在性癌 / 発症背景 / 分子病理学 |
Outline of Final Research Achievements |
To investigate the epidemiological and biological backgrounds for the occurrence of oral superficial carcinomas, which are recently increasing in number in Japan with an aging population, we collected those cases from several Asian countries as controls. We firstly established a science/evidence-based standard for histopathological diagnosis of oral superficial carcinomas, with which we eliminated diagnostic disparities among hospitals from those countries. As a result, we confirmed that our new diagnostic standard based on combined expressions of some particular molecules was useful for any cases whose ethnic and etiological backgrounds were obviously different from each other. Hence, we were successful in demonstrating the diagnostic standard certainly worked in any occasions. Among the expressions of the particular molecules, those of keratin 17 were shown by our cell machinery investigations to characterize dyskeratotic carcinoma cells, which mimicked epidermal orthokeratosis.
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Report
(5 results)
Research Products
(55 results)
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[Journal Article] Differential diagnosis of well-differentiated squamous cell carcinoma from non-neoplastic oral mucosal lesions: New cytopathologic evaluation method dependent on keratinization-related parameters but not nuclear atypism2017
Author(s)
Hara H, Misawa T, Ishii E, Nakagawa M, Koshiishi S, Amamiya K, Oyama T, Tominaga K, Cheng J, TanakaA, Saku T
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Journal Title
Diagnostic Cytopathology
Volume: 45
Issue: 5
Pages: 406-417
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Aberrant expression of the tight junction molecules claudin-1 and zonula occludens-1 mediates cell growth and invasion in oral squamous cell carcinoma2016
Author(s)
Babkair H, Yamazaki M, Uddin MS, Maruyama S, Abe T, Essa A, Sumita Y, Ahsan MS, Swelam W, Cheng J, Saku T
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Journal Title
Human Pathology
Volume: 57
Pages: 51-60
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Basaloid squamous cell carcinoma of the uvula: report of a case and review of the literature2016
Author(s)
Hara Y, Ikeda N, Takagi R, Horino K, Iida A, Nishiyama H, Hayashi T, Cheng J, Saku T
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Journal Title
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
Volume: 28
Issue: 3
Pages: 234-238
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Geriatric oral lesions: A multicentric study2016
Author(s)
Dhanuthai K, Rojanawatsirivej S, Somkotra T, Shin HI, Hong SP, Darling M, Ledderhof N, Khalili M, Thosaporn W, Rattana-Arpha P, Saku T
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Journal Title
Geriatrics & Gerontology International
Volume: 16
Issue: 2
Pages: 237-243
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 上顎骨腫瘍2015
Author(s)
隅田賢正, 程 クン, 丸山 智, 船山昭典, 小林正治, 西山秀昌, 林 孝文, 朔 敬
Organizer
第26回日本臨床口腔病理学会総会・学術大会
Place of Presentation
北海道大学学術交流会館, 札幌市
Year and Date
2015-07-29
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[Presentation] 口蓋腫瘍2013
Author(s)
程 クン, 丸山 智, 阿部達也, 山崎 学, 朔 敬
Organizer
第24回日本臨床口腔病理学会総会・学術大会
Place of Presentation
日本大学理工学部1号館 CSTホール、東京都
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