Involvement of DNA damage-independent and ATM-dependent stress response in tumor suppressive mechanism
Project/Area Number |
25340028
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Risk sciences of radiation and chemicals
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Research Institution | Kanazawa University |
Principal Investigator |
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | ATM / 酸化ストレス / 代謝ストレス / mTORC1 / mTOR / 細胞応答 |
Outline of Final Research Achievements |
ATM is involved in the regulation of energy metabolism, which is important for malignancy of glioma, via AMPK phosphorylation in addition to its DNA damage response. This energy metabolism pathway, especially mitochondrial energy production, may be an effective therapeutic target for glioma patients.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Association of a murine leukaemia stem cell gene signature based on nucleostemin promoter activity with prognosis of acute myeloid leukaemia in patients.2014
Author(s)
Ali MA, Naka K, Yoshida A, Fuse K, Kasada A, Hoshii T, Tadokoro Y, Ueno M, Ohta K, Kobayashi M, Takahashi C, Hirao A
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Journal Title
Biochem Biophys Res Commun
Volume: 450
Pages: 837-843
DOI
Related Report
Peer Reviewed
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[Journal Article] ATM mediates pRB function to control DNMT1 protein stability and DNA methylation.2013
Author(s)
Shamma A, Suzuki M, Hayashi N, Kobayashi M, Sasaki N, Nishiuchi T, Doki Y, Okamoto T, Kohno S, Muranaka H, Kitajima S, Yamamoto K, Takahashi C
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Journal Title
Molecular and Cellular Biology
Volume: 33
Pages: 3113-3124
DOI
Related Report
Peer Reviewed
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