| Project/Area Number |
25350179
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
OISHI Katsutaka 国立研究開発法人産業技術総合研究所, バイオメディカル研究部門, 研究グループ長 (50338688)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 体内時計 / 食生活 / 肥満 / メタボリックシンドローム / 時計遺伝子 / 機能性食品 / 睡眠 / 時間栄養学 / 骨格筋 / 体温 / 睡眠障害 / 光 / 時間運動学 / 概日リズム / 高脂肪食 / 活動量 |
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| Outline of Final Research Achievements |
Feeding at unusual times of the day (inactive phase) is thought to be associated with obesity and metabolic disorders in experimental animals and in humans. We compared metabolic functions between mice fed only during the sleep phase (daytime) and those fed only during the active phase (nighttime). Feeding during daytime desynchronizes peripheral clocks and causes obesity and metabolic disorders by inducing leptin resistance, hyperphagia, physical inactivity, hepatic fat accumulation and adiposity.
To find natural compounds that could modulate the biological clock, we developed a real-time molecular clock reporter system using neuronal cells derived from PER2::LUC mouse embryos. We discovered that natural compounds such as shikonin, aconitine, alisol A, paeonol, and (E)-cinnamic acid could shorten the circadian period of neuronal clock in vitro.
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