| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Adhesion and subsequent transmigration of blood monocytes across vascular endothelial cells are critical in early atherogenesis. We focused on the physical and mechanical interaction of monocytes and endothelial cells, and examined the role of TRPV2, Ca2+-permeable mechanosensor molecule expressed in endothelial cells. Biochemical analysis including TRPV2 knockdown and overexpression system revealed that TRPV2 is an essential molecule for cell survival by promoting cell migration and proliferation. It promotes cell migration by facilitating pseudopodium formation at the cell membrane through regulating actin cytoskeleton. The role of TRPV2 in the context of monocyte-endothelial interaction during transmigration is the subject of future study.
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