The previous clinical study about feasibility and utility of Steady Pressure Automatically Controlled Endoscopy at the time of gastrointestinal perforation

• Project/Area Number: 25350566
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical systems
• Research Institution: Osaka University
• Principal Investigator: Nakajima Kiyokazu 大阪大学, 国際医工情報センター, 特任教授(常勤) (30432537)
• Co-Investigator(Kenkyū-buntansha): 山崎 誠 大阪大学, 医学(系)研究科(研究院), 講師 (50444518) ; 高橋 剛 大阪大学, 医学(系)研究科(研究院), 助教 (50452389)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 内視鏡外科学 / 消化器内視鏡学 / 上部消化管学 / 実験外科学 / 胃十二指腸外科学 / 定圧自動送気内視鏡SPACE / 手動送気装置

Outline of Final Research Achievements

The purpose of this study was to improve insufflation technique to disseminate highly challenging endoscopic intervention e.g. endoscopic submucosal dissection (ESD), as safer and more standardized treatment. The study was conducted in stepwise manner, from basic to semi-clinical settings. An intentional gastric perforation was created in porcine models, to compare pressure dynamics between automatically insufflated group (group A) and blindly (manually) insufflated group (group B). The results were as follows:
1)In forceful insufflation animals, both gastric and intra-abdominal pressures were well controlled within preset range in group A, whereas excessively elevated in group B.　2)In clip closure models, both pressures were again within acceptable range in group A. The intra-abdominal pressure, however, was significantly elevated beyond preset range in group B.　3)In semi-clinical settings, the intra-abdominal pressure was significantly elevated in group B.

Research Products

• [Journal Article] Novel management of postoperative pain using only oral analgesics after LADG (2016)
  • Author(s): Mikami J, Takiguchi S, Miyazaki Y, Takahashi T, Kurokawa Y, Yamasaki M, Miyata H, Nakajima K, Mori M, Doki Y
  • Journal Title: Surgical Today Volume: 46 Pages: 117-122
  • Peer Reviewed
• [Journal Article] A novel device for cleaning the camera port during laparoscopic surgery (2016)
  • Author(s): Eiji Kobayashi, Mamoru Kakuda, Yusuke Tanaka, Akiko Morimoto, Tomomi Egawa-Takata, Shinya Matsuzaki, Toshihiro Kimura, Yutaka Ueda, Kiyoshi Yoshino, Kiyokazu Nakajima, Tadashi Kimura
  • Journal Title: Surg Endosc Volume: 30 Pages: 330-334
  • Peer Reviewed
• [Journal Article] Laparoscopic surgery for esophageal achalasia Multiport vs single-incision approach (2016)
  • Author(s): Shuichi Fukuda, Kiyokazu Nakajima, Yasuhiro Miyazaki, Tsuyoshi Takahashi, Tomoki Makino, Yukinori Kurokawa, Makoto Yamasaki, Hiroshi Miyata, Shuji Takiguchi, Masaki Mori, Yuichiro Doki
  • Journal Title: Asian Journal of Endoscopic Surgery Volume: 9 Pages: 14-20
  • Peer Reviewed
• [Journal Article] Percutaneous endoscopic gastrostomy under steady pressure automatically controlled endoscopy: First clinical series (2016)
  • Author(s): Hiroyuki Imaeda, Kiyokazu Nakajima, Naoki Hosoe, Masanori Nakahara, Shinichiro Zushi, Motohiko Kato, Kazuhiro Kashiwagi, Yasushi Matsumoto, Kayoko Kimura, Rieko Nakamura, Norihito Wada, Masahiko Tsujii, Naohisa Yahagi, Toshifumi Hibi, Takanori Kanai, Tetsuo Takehara, Haruhiko Ogata
  • Journal Title: Wolrd Jounal of Gastrointestinal Endoscopy Volume: 8 Pages: 186-191
  • Peer Reviewed
• [Journal Article] Laparoscopic surgery for esophageal achalasia: Multiport vs single-incision approach (2016)
  • Author(s): Shuichi Fukuda, Kiyokazu Nakajima, Yasuhiro Miyazaki, Tsuyoshi Takahashi, Tomoki Makino, Yukinori Kurokawa, Makoto Yamasaki, Hiroshi Miyata, Shuji Takiguchi, Masaki Mori, Yuichiro Doki
  • Journal Title: Asian Journal of Endoscopic Surgery Volume: 9 Pages: 14-20
  • Peer Reviewed
• [Journal Article] Single-incision laparoscopic surgery for stricturing and penetrating Crohn's disease. (2016)
  • Author(s): Tsunekazu Mizushima, Kiyokazu Nakajima, Hiroshi Takeyama, Atsushi Naito, Hideki Osawa, Mamoru Uemura, Junichi Nishimura, Taishi Hata, Ichiro Takemasa, Hirofumi Yamamoto, Yuichiro Doki, Masaki Mori
  • Journal Title: Surg Today Volume: 46 Pages: 203-208
  • Peer Reviewed
• [Journal Article] Perioperative therapy for esophageal cancer. (2015)
  • Author(s): Makoto Yamasaki, Hiroshi Miyata, Yasuhiro Miyazaki, Tsuyoshi Takahashi, Yukinori Kurokawa, Kiyokazu Nakajima, Shuji Takiguchi, Masaki Mori, Yuichiro Doki
  • Journal Title: Gen Thorac Cardiovasc Surg Volume: 62 Pages: 531-540
  • Peer Reviewed
• [Journal Article] Monitoring gastric cancer progression with circulating tumour DNA. (2015)
  • Author(s): Hamakawa T, Kukita Y, Kurokawa Y, Miyazaki Y, Takahashi T, Yamasaki M, Miyata H, Nakajima K, Taniguchi K, Takiguchi S, Mori M, Doki Y, Kato K
  • Journal Title: Br J Cancer Volume: 112 Pages: 352-356
  • Peer Reviewed
• [Journal Article] Clinical outcomes of laparoscopic partial gastrectomy for gastric submucosal tumors (2015)
  • Author(s): Masashi Hirota, Kiyokazu Nakajima, Yasuhiro Miyazaki, Tsuyoshi Takahashi, Yukinori Kurokawa,
  • Journal Title: Asian J Endosc Surg Volume: 8 Pages: 24-28
  • Peer Reviewed
• [Journal Article] Chylothorax After Esophagectomy Cured by Intranodal Lymphangiography: A Case Report (2015)
  • Author(s): Yamamoto M, Miyata H, Yamasaki M, Maeda N, Miyazaki Y, Takahashi T, Kurokawa Y, Nakajima K, Takiguchi S, Mori M, Doki Y
  • Journal Title: Anticancer Research Volume: 35 Pages: 891-896
  • Peer Reviewed
• [Journal Article] Surgical strategy for the gastric gastrointestinal stromal tumors (GISTs) larger than 5 cm: Laparoscopic surgery is feasible, safe, and oncologically acceptable (2015)
  • Author(s): Takahashi T, Nakajima K, Miyazaki Y, Miyazaki Y, Kurokawa Y, Yamasaki M, Miyata H, Takiguchi S, Nishida T, Mori M, Doki Y
  • Journal Title: Surg Laparosc Endosc Percutan Tech Volume: 25 Pages: 114-118
  • Peer Reviewed
• [Journal Article] Preoperative systemic and intraperitoneal chemotherapy consisting of S-1, cisplatin and docetaxel in patients with marginally resectable gastric cancer. (2015)
  • Author(s): Kurokawa Y, Hamakawa T, Miyazaki Y, Takahashi T, Yamasaki M, Miyata H, Nakajima K, Takiguchi S, Mori M, Doki Y
  • Journal Title: Anticancer Res Volume: 35 Pages: 2223-2228
  • Peer Reviewed
• [Journal Article] Laparoscopic intraoperative navigation surgery for gastric cancer using real-time rendered 3D CT images. (2015)
  • Author(s): Takiguchi S, Fujiwara Y, Yamasaki M, Miyata H, Nakajima K, Nishida T, Sekimoto M, Hori M, Nakamura H, Mori M, Doki Y
  • Journal Title: Surg Today Volume: 45 Pages: 618-624
  • Peer Reviewed
• [Journal Article] High infiltration of tumor-associated macrophages is associated with a poor response to chemotherapy and poor prognosis of patients undergoing neoadjuvant chemotherapy for esophageal cancer. (2015)
  • Author(s): Sugimura K, Miyata H, Tanaka K, Takahashi T, Kurokawa Y, Yamasaki M, Nakajima K, Takiguchi S, Mori M, Doki Y
  • Journal Title: J Surg Oncol Volume: 111 Pages: 752-759
  • Peer Reviewed
• [Journal Article] Use of double-lumen peripherally inserted central catheters for safer perioperative management of esophageal cancer patients (2015)
  • Author(s): Fukuda S, Nakajima K, Miyazaki Y, Takahashi T, Kurokawa Y, Yamasaki M, Miyata H, Takiguchi S, Mori M, Doki Y
  • Journal Title: JVA (The Journal of Vascular Access) Volume: 16 Pages: 338-343
  • Peer Reviewed
• [Journal Article] Gene therapy with SOCS1 for gastric cancer induces G2/M arrest and has an antitumour effect on peritoneal carcinomatosis. (2015)
  • Author(s): Natatsuka R, Takahashi T, Serada S, Fujimoto M, Ookawara T, Nishida T, Hara H, Nishigaki T, Harada E, Murakami T, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Miyata H, Nakajima K, Takiguchi S, Kishimoto T, Mori M, Doki Y, Naka T
  • Journal Title: British Journal of Cancer Volume: 113 Pages: 433-442
  • Peer Reviewed
• [Journal Article] Effects of ghrelin administration on the early postoperative inflammatory response after esophagectomy (2015)
  • Author(s): "Akihiro Takata, Shuji Takiguchi, Kohei Murakami, Yasuhiro Miyazaki, Hiroshi Miyata, Tsuyoshi Takahashi, Yukinori Kurokawa. Makoto Yamasaki,
  • Journal Title: Surg Today Volume: 45 Pages: 1025-1031
  • Peer Reviewed
• [Journal Article] Randomized Phase II Study of the Anti-inflammatory Effect of Ghrelin During the Postoperative Period of Esophagectomy (2015)
  • Author(s): Takata A, Takiguchi S, Miyazaki Y, Miyata H, Takahashi T, Kurokawa Y, Yamasaki M, Nakajima K, Mori M, Kangawa K, Doki Y
  • Journal Title: Annals of Surgery Volume: 262 Pages: 230-236
  • Peer Reviewed
• [Journal Article] Clinical Importance of Supraclavicular Lymph Node Metastasis After Neoadjuvant Chemotherapy for Esophageal Squamous Cell Carcinoma. (2015)
  • Author(s): Miyata H, Yamasaki M, Miyazaki Y, Takahashi T, Kurokawa Y, Nakajima K, Takiguchi S, Mori M, Doki Y
  • Journal Title: Ann Surg Volume: 262 Pages: 280-285
  • Peer Reviewed
• [Journal Article] Gastric endoscopic submucosal dissection under steady pressure automatically controlled endoscopy (SPACE); a multicenter randomized preclinical trial. (2015)
  • Author(s): Yamada T, Hirota M, Tsutsui S, Kato M, Takahashi T, Yasuda K, Sumiyama K, Tsujii M, Takehara T, Mori M, Doki Y, Nakajima K.
  • Journal Title: Surg Endosc Volume: 29 Pages: 2748-2755
  • Peer Reviewed
• [Journal Article] Pyruvate Kinase M2 Modulates Esophageal Squamous Cell Carcinoma Chemotherapy Response by Regulating the Pentose Phosphate Pathway (2015)
  • Author(s): Fukuda S, Miyata H, Miyazaki Y, Makino T, Takahashi T, Kurokawa Y, Yamasaki M, Nakajima K, Takiguchi S, Mori M, Doki Y
  • Journal Title: Ann Surg Oncol Volume: 22 Pages: 1461-1468
  • Peer Reviewed
• [Journal Article] Feasibility and safety of optical biopsy using probe based confocal laser endomicroscopy for peritoneal dissemination (2015)
  • Author(s): Hara H, Takahashi T, Nakatsuka R, Higashi S, Miyazaki Y , Kurokawa Y, Takiguchi S, Mori M, Doki Y, Nakajima K
  • Journal Title: Jounal of Gstroenterology and Hepatology Volume: 30 Pages: 209-209
  • Peer Reviewed
• [Journal Article] Dynamics of intraluminal pressure of the sophagus ESD in preclinical experiments (2015)
  • Author(s): Y Miyazaki, M Yamasaki, Y Kurokawa, T Makino, S Takiguchi, M Mori, Y Doki, K Nakajima
  • Journal Title: Jounal of Gstroenterology and Hepatology Volume: 30 Pages: 316-316
  • Peer Reviewed
• [Journal Article] Feasibility study of real-time intestinal bloodstream evaluation using probe-based confocal laser endomicroscopy in porcine intestinal ischemia models. (2015)
  • Author(s): T Takahashi, R Nakatsuka, H Hara, S Higashi, Y Miyazaki, Y Kurokawa, S Takiguchi, M Mori, Y Doki, K Nakajima
  • Journal Title: Jounal of Gstroenterology and Hepatology Volume: 30 Pages: 71-71
  • Peer Reviewed
• [Journal Article] Gastric endoscopic submucosal dissection under steady pressure automatically controlled endoscopy (SPACE); a multicenter randomized preclinical trial. (2014)
  • Author(s): Yamada T, Hirota M, Tsutsui S, Kato M, Takahashi T, Yasuda K, Sumiyama K, Tsujii M, Takehara T, Mori M, Doki Y, Nakajima K.
  • Journal Title: Surg Endosc Volume: ―
  • Peer Reviewed / Open Access
• [Journal Article] Steady Pressure CO2 Colonoscopy: Its Feasibility and Underlying Mechanism. (2014)
  • Author(s): Hirota M., Miyazaki Y., Takahashi T., Yamasaki M., Takiguchi S., Mori M., Doki Y., Nakajima K.
  • Journal Title: Dis Colon Rectum Volume: 57 Pages: 1120-1128
  • Peer Reviewed / Open Access
• [Journal Article] Esophageal submucosal dissection under steady pressure automatically controlled endoscopy (SPACE) : a clinical feasibility study. (2014)
  • Author(s): Kato M, Nakajima K, Yamada T, Hirota M, Miyazaki Y, Yamasaki M, Nishida T, Mori M, Doki Y, Tujii M, Takehara T.
  • Journal Title: Endoscopy Volume: 46 Pages: 680-684
  • Peer Reviewed / Open Access
• [Presentation] #1358 Feasibility and safety of optical biopsy using probe based confocal laser endomicroscopy for peritoneal dissemination (2015)
  • Author(s): Hara H, Takahashi T, Nakatsuka R, Higashi S, Miyazaki Y, Kurokawa Y, Takiguchi S, Mori M, Doki Y, Nakajima K
  • Organizer: Asian Pacific Digestive Week (APDW)
  • Place of Presentation: Taipei Taiwan
  • Year and Date: 2015-12-05
  • Int'l Joint Research
• [Presentation] # 1497 Dynamics of intraluminal pressure of the esophagus ESD in preclinical experiments (2015)
  • Author(s): Higashi S, Takahashi T, Miyazaki Y, Yamasaki M, Kurokawa Y, Makino T, Takiguchi S, Mori M, Doki Y, Nakajima K
  • Organizer: APDW
  • Place of Presentation: Taipei Taiwan
  • Year and Date: 2015-12-05
  • Int'l Joint Research
• [Presentation] #1314 Feasibility study of real-time intestinal bloodstreamevaluation using probe-based confocal laser endomicroscopy in porcine intestinal ischemia models (2015)
  • Author(s): Takahashi T, Nakatsuka R, Hara H, Higashi S, Miyazaki Y, Kurokawa Y, Takiguchi S, Mori M, Doki Y, Nakajima K
  • Organizer: APDW
  • Place of Presentation: Taipei Taiwan
  • Year and Date: 2015-12-04
  • Int'l Joint Research
• [Presentation] Simposio-Cena de Bienvenida (2015)
  • Author(s): Nakajima K
  • Organizer: International NOTES W.I.D.E.R.
  • Place of Presentation: Barcelona Spain
  • Year and Date: 2015-11-23
  • Int'l Joint Research / Invited
• [Presentation] A novel portable endoscopy system for universal access. (2015)
  • Author(s): Nakajima K
  • Organizer: International NOTES W.I.D.E.R.
  • Place of Presentation: Barcelona Spain
  • Year and Date: 2015-11-23
  • Int'l Joint Research / Invited
• [Presentation] Project ENGINE: Our R&D and Achievements (2015)
  • Author(s): Nakajima K
  • Organizer: AIMS Academy
  • Place of Presentation: Milan Italy
  • Year and Date: 2015-11-19
  • Int'l Joint Research / Invited
• [Presentation] ENGINE & HEART: R&D of UHC Devices based on Unmet Needs in LMICs (2015)
  • Author(s): Nakajima K
  • Organizer: AIMS Academy
  • Place of Presentation: Milan Italy
  • Year and Date: 2015-11-19
  • Int'l Joint Research / Invited
• [Presentation] CO2 stabilizer for endoscopic diagnosis and interventions. (2015)
  • Author(s): Nakajima K
  • Organizer: Endocourse milan 2015 endoscopic management of gastrointestinal and pancreatico-biliary neoplasia 6th advanced course
  • Place of Presentation: Milan Italy
  • Year and Date: 2015-11-18
  • Int'l Joint Research / Invited
• [Presentation] Next Generation Endoscopy through Surgeon's Eyes (2015)
  • Author(s): Nakajima K
  • Organizer: DDW
  • Place of Presentation: Washington D.C. U.S.A
  • Year and Date: 2015-05-17
  • Int'l Joint Research
• [Presentation] 次世代内視鏡治療の実現へ向けた研究開発の最前線 (2015)
  • Author(s): 中島清一
  • Organizer: 奈良県内視鏡下手術研究会
  • Place of Presentation: 奈良
  • Year and Date: 2015-02-28
  • Invited
• [Presentation] 定圧自動送気内視鏡（SPACE）を用いた胃ESD ～多施設共同基礎研究～ (2015)
  • Author(s): 山田拓哉、高橋剛、加藤元彦、安田一弘、炭山和穀、中島清一
  • Organizer: 日本消化管学会
  • Place of Presentation: 東京
  • Year and Date: 2015-02-14
• [Presentation] 二つの内視鏡：境界を乗り越えた先にあるもの (2014)
  • Author(s): 中島清一
  • Organizer: 日本消化器内視鏡学会
  • Place of Presentation: 神戸
  • Year and Date: 2014-10-25
  • Invited
• [Presentation] 胃穿孔モデルにおける定圧自動送気内視鏡の安全性の検討
  • Author(s): 山田拓哉、高橋剛、中島清一
  • Organizer: 第85回日本消化器内視鏡学会
  • Place of Presentation: 国立京都国際会館
• [Remarks] 大阪大学 次世代内視鏡治療学ホームページ
  • URL: http://project-engine.org/
• [Patent(Industrial Property Rights)] INSUFFLATION SYSTEM AND INSUFFLATION APPARATUS (2015)
  • Inventor(s): 鳥澤信幸、宮本学、中島清一
  • Industrial Property Rights Holder: 富士フイルム株式会社、国立大学法人大阪大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-04-07
  • Overseas
• [Patent(Industrial Property Rights)] INSUFFLATION SYSTEM AND INSUFFLATION APPARATUS (2015)
  • Inventor(s): 鳥澤信幸、宮本学、中島清一
  • Industrial Property Rights Holder: 富士フイルム株式会社、国立大学法人大阪大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-04-08
  • Overseas
• [Patent(Industrial Property Rights)] INSUFFLATION SYSTEM AND INSUFFLATION APPARATUS (2015)
  • Inventor(s): 鳥澤信幸、宮本学、中島清一
  • Industrial Property Rights Holder: 富士フイルム株式会社、国立大学法人大阪大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-04-09
  • Overseas
• [Patent(Industrial Property Rights)] INSUFFLATION SYSTEM AND INSUFFLATION APPARATUS (2015)
  • Inventor(s): 鳥澤信幸、宮本学、中島清一
  • Industrial Property Rights Holder: 富士フイルム株式会社、国立大学法人大阪大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-04-09
  • Overseas
• [Patent(Industrial Property Rights)] 送気システム (2015)
  • Inventor(s): 林健太郎、中島清一
  • Industrial Property Rights Holder: 富士フイルム株式会社、国立大学法人大阪大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-05-22
• [Patent(Industrial Property Rights)] INSUFFLATION SYSTEM (2015)
  • Inventor(s): 林健太郎、中島清一
  • Industrial Property Rights Holder: 富士フイルム株式会社、国立大学法人大阪大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-05-26
  • Overseas
• [Patent(Industrial Property Rights)] INSUFFLATION SYSTEM (2015)
  • Inventor(s): 林健太郎、中島清一
  • Industrial Property Rights Holder: 富士フイルム株式会社、国立大学法人大阪大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-05-26
  • Overseas
• [Patent(Industrial Property Rights)] INSUFFLATION SYSTEM (2015)
  • Inventor(s): 林健太郎、中島清一
  • Industrial Property Rights Holder: 富士フイルム株式会社、国立大学法人大阪大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-05-27
  • Overseas
• [Patent(Industrial Property Rights)] 内視鏡用オーバーチューブ (2014)
  • Inventor(s): 中島清一
  • Industrial Property Rights Holder: 国立大学法人大阪大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-09-24
  • Acquisition Date: 2015-11-13
• [Patent(Industrial Property Rights)] GAS SUPPLY APPARATUS (2014)
  • Inventor(s): 鳥澤信幸、林健太郎、宮本学、中島清一
  • Industrial Property Rights Holder: 鳥澤信幸、林健太郎、宮本学、中島清一
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-09-16
  • Overseas
• [Patent(Industrial Property Rights)] GAS SUPPLY APPARATUS (2014)
  • Inventor(s): 鳥澤信幸、林健太郎、宮本学、中島清一
  • Industrial Property Rights Holder: 鳥澤信幸、林健太郎、宮本学、中島清一
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-09-15
  • Overseas
• [Patent(Industrial Property Rights)] GAS SUPPLY APPARATUS (2014)
  • Inventor(s): 鳥澤信幸、林健太郎、宮本学、中島清一
  • Industrial Property Rights Holder: 鳥澤信幸、林健太郎、宮本学、中島清一
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-09-16
  • Overseas
• [Patent(Industrial Property Rights)] 送気システム及び送気装置 (2014)
  • Inventor(s): 鳥澤信幸、宮本学、中島清一
  • Industrial Property Rights Holder: 鳥澤信幸、宮本学、中島清一
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-04-09
• [Patent(Industrial Property Rights)] 送気システム及び送気装置 (2014)
  • Inventor(s): 鳥澤信幸、宮本学、中島清一
  • Industrial Property Rights Holder: 鳥澤信幸、宮本学、中島清一
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-04-09