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Treatment for Dysphagia -strategy for brain plasticity and upper esophageal sphincter-

Research Project

Project/Area Number 25350639
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionFujita Health University

Principal Investigator

AOYAGI Yoichiro  藤田保健衛生大学, 医学部, 准教授 (30286661)

Co-Investigator(Kenkyū-buntansha) Kagaya Hitoshi  藤田保健衛生大学, 医学部, 教授 (40282181)
山本 敏泰  岡山理科大学, 工学部, 教授 (20412158)
Co-Investigator(Renkei-kenkyūsha) Saitoh Eiichi  藤田保健衛生大学, 医学部, 教授 (50162186)
Inamoto Yoko  藤田保健衛生大学, 医療科学部, 准教授 (70612547)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords摂食嚥下リハビリテーション / 上部食道括約筋 / 治療的電気刺激 / 電気刺激 / 輪状咽頭筋 / ブロック / 摂食嚥下障害 / 嚥下反射
Outline of Final Research Achievements

Peripheral nerve sensory stimulation was applied to human frontal neck. The number of natural stimulation increased and the number of RSST did not increase. These results possibly suggest that peripheral nerve sensory stimulation induces swallowing reflex pathway through the brain stem.
Twenty-six healthy males were evaluated by 3D dynamic CT while swallowing 10-mL liquid. The distances of hyoid bone and thyroid cartilage forward movements were significantly correlated with the UES midline diameter. In all cases, forward movement of the hyoid bone initiated before or simultaneously with the onset of UES opening. However, in 5 cases, forward movement of thyroid cartilage initiated after UES opening onset. These results indicate that hyoid and laryngeal forward movements play different roles in UES opening with respect to their timing; the hyoid forward movement acts as the trigger that pulls open UES, whereas the laryngeal forward movement helps in maintaining the UES opening.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (19 results)

All 2016 2015 2014 2013

All Journal Article (9 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 2 results,  Open Access: 1 results) Presentation (10 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] 摂食嚥下障害における神経生理学的評価 -高解像度マノメトリーと筋電図検査-2016

    • Author(s)
      青柳陽一郎
    • Journal Title

      Japanese journal of rehabilitation medicine

      Volume: 53

    • NAID

      130005166256

    • Related Report
      2015 Annual Research Report
  • [Journal Article] リハビリテーション医学評価としての電気生理学 電気生理学的検査の摂食嚥下領域への応用2015

    • Author(s)
      青柳 陽一郎
    • Journal Title

      Japanese journal of rehabilitation medicine

      Volume: 53 Pages: 344-347

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Delayed Pharyngeal Response in Chew-Swallow Does Not Increase Risk of Aspiration in Individuals with Stroke2015

    • Author(s)
      Kagaya H, Saitoh E, Shibata S, Onogi K, Aoyagi Y, Inamoto Y, Ozeki M, Ota K
    • Journal Title

      J Am Geriatr Soc

      Volume: 63 Issue: 8 Pages: 1698-1699

    • DOI

      10.1111/jgs.13570

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Sequential coordination between lingual and pharyngeal pressures produced during dry swallowing.2014

    • Author(s)
      Yano J, Aoyagi Y, Ono T, Hori K, Yamaguchi W, Fujiwara S, Kumakura I, Minagi S, Tsubahara A
    • Journal Title

      Biomed Res Int

      Volume: 2014 Pages: 1-10

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 嚥下訓練に併行して、嚥下補助装置の応用とボツリヌス療法を行い全量経口摂取可能となった小脳・脳幹梗塞の1例2014

    • Author(s)
      池野雅裕, 熊倉勇美, 皆木省吾, 目谷浩通, 青柳陽一郎
    • Journal Title

      顎顔面補綴

      Volume: 37 Pages: 64-68

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 脳卒中ユニット(SU)における専門職チーム医療2014

    • Author(s)
      青柳陽一郎, 小野木啓子
    • Journal Title

      Journal of Clinical Rehabilitation

      Volume: 23 Pages: 424-429

    • Related Report
      2014 Research-status Report
  • [Journal Article] 痙縮筋に対するボツリヌス治療の適応と手技の実際2014

    • Author(s)
      青柳陽一郎
    • Journal Title

      MEDICAL REHABILITATION

      Volume: 180 Pages: 45-50

    • Related Report
      2014 Research-status Report
  • [Journal Article] 嚥下造影検査の歴史と進歩2014

    • Author(s)
      青柳陽一郎
    • Journal Title

      Monthly Book Medical Rehabilitation

      Volume: 167 Pages: 7-12

    • Related Report
      2013 Research-status Report
  • [Journal Article] Dynamic change in hyoid muscle length associated with trajectory of hyoid bone during swallowing: analysis using 320-row area detector computed tomography.2013

    • Author(s)
      Okada T, Aoyagi Y, Inamoto Y, Saitoh E, Kagaya H, Shibata S, Ota K, Ueda K.
    • Journal Title

      J Appl Physiol

      Volume: 115 Pages: 1138-1145

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Physiological characteristics of effortful, supraglottic swallow, and Mendelsohn maneuver evaluated by high-resolution manometry2016

    • Author(s)
      Yoichiro Aoyagi, Keiko Aihara, Yoko Inamoto, Sayuri Imaeda, Seiko Shibata, Hitoshi Kagaya, Eiichi Saitoh
    • Organizer
      16th Annual Dysphagia Research Society Annual Meeting
    • Place of Presentation
      Tucson
    • Year and Date
      2016-02-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dysphagia in patients with cardiac failure2016

    • Author(s)
      Yoichiro Aoyagi, Yuko Furuta, Yuji Kono, Wataru Kikuchi, Mizukosi Eriko, Kaoru Yamada, Seiko Shibata, Hitoshi Kagaya, Eiichi Saitoh
    • Organizer
      5th Asia-Oceanian Conference of Physical and Rehabilitation Medicine
    • Place of Presentation
      Cebu Philippines
    • Year and Date
      2016-02-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Asymmetrical muscle activity in patients with Wallenberg syndrome evaluated using 3D dynamic CT2015

    • Author(s)
      Yoichiro Aoyagi、Takeshi Okada、Eiichi Saitoh、Yoko Inamoto、 Hitoshi Kagaya、Seiko Shibata
    • Organizer
      21st annual meeting of Japanese society dysphagia rehabilitation
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Recent findings on manometry and EMG applicable to swallowing rehabilitation2015

    • Author(s)
      Yoichiro Aoyagi
    • Organizer
      21st annual meeting of Japanese society dysphagia rehabilitation
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Mendelsohn Maneuver: Kinematic analysis using 3D dynamic computed tomography2015

    • Author(s)
      Yoko Inamoto, Eiichi Saitoh, Yoichiro Aoyagi, Seiko Shibata, Hitoshi Kagaya, Koji Hara, Kazuhiro Katada, Jeffrey Palmer
    • Organizer
      15th Annual Dysphagia Research Society Annual Meeting
    • Place of Presentation
      Chicago
    • Year and Date
      2015-03-11 – 2015-03-15
    • Related Report
      2014 Research-status Report
  • [Presentation] Incidence of pneumonia is assoiated with esophageal dysphagia in patients with Wallenberg syndrome2015

    • Author(s)
      Yoichiro Aoyagi, Takeshi Okada, Eiichi Saitoh, Koji Hara, Yoko Inamoto, Seiko Shibata, Hitoshi Kagaya
    • Organizer
      15th Annual Dysphagia Research Society Annual Meeting
    • Place of Presentation
      Chicago
    • Year and Date
      2015-03-11 – 2015-03-14
    • Related Report
      2014 Research-status Report
  • [Presentation] Difference of thyroid and hyoid trajectory in viscosity and individuals during swallowing: kinematic analysis using 3D dynamic Computed Tomography2015

    • Author(s)
      Hara K, Inamoto Y, Saitoh E, Aoyagi Y, Kagaya H, Shibata S, Kanamori D, Fujii N, Tohara H
    • Organizer
      15th Annual Dysphagia Research Society Annual Meeting
    • Place of Presentation
      Chicago
    • Year and Date
      2015-03-11 – 2015-03-14
    • Related Report
      2014 Research-status Report
  • [Presentation] Application of elecrophysiological techniques for swallowing evaluation2014

    • Author(s)
      Yoichiro Aoyagi
    • Organizer
      51th Japan Rehabilitation Society Meeting
    • Place of Presentation
      Nagoya Congress Center, Nagoya, Aichi
    • Year and Date
      2014-06-05 – 2014-06-07
    • Related Report
      2014 Research-status Report
  • [Presentation] Changes in pharyngeal muscle activities during swallowing: analysis using 3D dynamic CT2014

    • Author(s)
      Yoichiro Aoyagi, Takeshi Okada, Saitoh Eiichi, Yoko Inamoto, Seiko Shibata, Hitoshi Kagaya, Kazuhiro Katada
    • Organizer
      14th Annual Dysphagia Research Society Annual Meeting
    • Place of Presentation
      Nashville, Tennessee
    • Related Report
      2013 Research-status Report
  • [Presentation] Asymmetrical muscle activity in patients with Wallenberg syndrome: a preliminary study using 3D dynamic CT2014

    • Author(s)
      Takeshi Okada, Yoichiro Aoyagi, Saitoh Eiichi, Yoko Inamoto, Hitoshi Kagaya, Seiko Shibata, Koichiro Matsuo
    • Organizer
      14th Annual Dysphagia Research Society Annual Meeting
    • Place of Presentation
      Nashville, Tennessee
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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