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NO/calcium regulation mechanism in stretch-induced glucose uptake of skeletal muscle

Research Project

Project/Area Number 25350893
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied health science
Research InstitutionUniversity of Shizuoka

Principal Investigator

OBARA Kazuo  静岡県立大学, 薬学部, 講師 (60117611)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords骨格筋 / 糖代謝 / ストレッチ / インテグリン / NO / リアノジン受容体 / カルシウム / CaMKII / 糖取り込み / ニトロシル化 / NO / GLUT4 / GLUT4
Outline of Final Research Achievements

The mechanism of stretch-stimulated glucose uptake in skeletal muscle was investigated. Our results suggest that stretch produces NO through nitric oxide synthase activation and increases calcium release from sarcoplasmic reticulum (SR) by S-nitrosylation of ryanodine receptor of SR, resulting increase in glucose uptake through CaMKII activation. Our results also suggest that stretch-induced glucose uptake involves insulin- and contraction-independent pathways.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (9 results)

All 2016 2015 2014 2013 Other

All Journal Article (1 results) Presentation (8 results)

  • [Journal Article] Myosin Phosphorylation Dissociated from Force under Hypoxic and Glucose-Free Conditions in the Guinea Pig Taenia Caeci.2014

    • Author(s)
      Yukisato Ishida, Kazuo Obara, Richard J Paul
    • Journal Title

      J. Muscle Res. Cell Motil.

      Volume: 35 Pages: 243-243

    • Related Report
      2014 Research-status Report
  • [Presentation] マウス骨格筋の伸展誘発性糖取り込み機構2016

    • Author(s)
      小原 一男、宇田 宗晃、滝口 茂幸、能代 裕也、石川 智久
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] マウス骨格筋における伸展誘発性糖取り込み機構2015

    • Author(s)
      小原一男
    • Organizer
      筋生理の集い
    • Place of Presentation
      慈恵会医科大学・高木会館 (東京都港区)
    • Year and Date
      2015-12-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] 骨格筋糖取り込み増強作用における緑茶エピガロカテキンガレートの脱リン酸化酵素阻害薬としての作用2015

    • Author(s)
      小原一男
    • Organizer
      静岡県立大学USフォーラム2015
    • Place of Presentation
      静岡県立大学(静岡県静岡市)
    • Year and Date
      2015-09-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] ミオシン軽鎖3リン酸化調節におけるPP2Aの役割2015

    • Author(s)
      小原一男
    • Organizer
      第57回日本平滑筋学会総会
    • Place of Presentation
      山口大学小串キャンパス(山口県宇部市)
    • Year and Date
      2015-08-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] マウス骨格筋における緑茶エピガロカテキンガレートによる糖取り込み増強作用2014

    • Author(s)
      小原一男、石川智久
    • Organizer
      第61回中部日本生理学会大会
    • Place of Presentation
      名古屋市
    • Year and Date
      2014-11-06 – 2014-11-07
    • Related Report
      2014 Research-status Report
  • [Presentation] 緑茶エピガロカテキンガレートによる骨格筋糖取り込み増強作用への67LRを介する細胞骨格リモデリングの関与について2014

    • Author(s)
      小原一男
    • Organizer
      静岡県立大学USフォーラム2014
    • Place of Presentation
      静岡市
    • Year and Date
      2014-09-25
    • Related Report
      2014 Research-status Report
  • [Presentation] Myosin Phosphorylation Dissociated from Force under Hypoxic and Glucose-Free Conditions in the Guinea Pig Taenia Caeci.2013

    • Author(s)
      Yukisato Ishida
    • Organizer
      Regulatory Circuits in Cell Motility a Symposium honoring David Hartshorne
    • Place of Presentation
      Philadelphia, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] 緑茶エピガロカテキンガレートによる骨格筋糖取り込み増強機序の解明

    • Author(s)
      小原一男
    • Organizer
      静岡県立大学USフォーラム2013
    • Place of Presentation
      静岡
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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