Lipid metabolism of vegetarians with polymorphism of fatty acid desaturase.
| Project/Area Number |
25350904
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Kagawa Nutrition University |
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Principal Investigator |
Kagawa Yasuo 女子栄養大学, 栄養学部, 教授 (30048962)
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| Co-Investigator(Kenkyū-buntansha) |
IWAMOTO Sadahiko 自治医科大学, 医学部, 教授 (10232711)
KAMACHI Keiko 女子栄養大学, 付属研究所, 教授 (20365810)
TANAKA Akira 女子栄養大学, 栄養学部, 教授 (70171733)
KAWABATA Terue 女子栄養大学, 栄養学部, 教授 (80190932)
NAKAYAM Kazuhiro 自治医科大学, 医学部, 講師 (90433581)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 菜食者 / 遺伝子多型 / ドコサヘキサエン酸 / エイコサペンタエン酸 / アラキドン酸 / 脂肪酸不飽和化酵素 / 純菜食者 / 魚菜食者 / 菜食主義者 / 魚菜食 / 循環器疾患 / 和食 / ステアリドン酸 / 脂肪酸不飽和化酵素多型 / 血清脂肪酸 |
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| Outline of Final Research Achievements |
Purpose: Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are needed to maintain health, but vegetarians hardly take them. Conversion of the plant-derived -linolenic acid (ALA) to EPA and DHA, and linoleic acid to arachidonic acid (AA) requires 5 desaturase, and the ability is lower in carriers of its genetic polymorphism (rs174547) C allele than those with T allele. Thus, the health status of the C allele carriers were surveyed.
Results: DHA intake of vegans + lactovegetarians was 0, and their serum and erythrocyte ALA was higher, and serum EPA and DHA were lower, and ω3 index was as low as 3.2 in TC/CC genotypes, and serum AA was much lower compared with those of TT genotype. The health indices of vegans + lactovegetarians were better than that of omnivores studied by Japanese National Nutrition Survey. The C carriers may keep health by their high EPA+DHA/AA ratio and preferentially preserve EPA/DHA to compensate low DHA intake.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Associations between a fatty acid desaturase gene polymorphism and blood arachidonic acid compositions in Japanese elderly.2016
Author(s)
Horiguchi S, Nakayama K, Iwamoto S, Ishijima A, Minezaki T, Baba M, Kontai Y, Horikawa C, Kawashima H, Shibata H, Kagawa Y, Kawabata T.
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Journal Title
Prostaglandins Leukot Essent Fatty Acids.
Volume: 105
Pages: 9-14
DOI
Related Report
Peer Reviewed
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[Journal Article] Heterogeneity of the Fatty Acid Composition of Japanese Placentae for Determining the Perinatal Fatty Acid Status: a Methodological Study2015
Author(s)
Yamazaki I, Kimura F, Nakagawa K, Nakai K, Arima T, Kawabata T, Kagawa Y, Saitoh S, Mizuno S, Yaegashi N, Miyazawa T.
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Journal Title
Journal of Oleo Science
Volume: 64
Issue: 8
Pages: 905-914
DOI
NAID
ISSN
1345-8957, 1347-3352
Related Report
Peer Reviewed / Open Access
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[Presentation] Influence of a fatty acid desaturase gene polymorphism on blood long-chain fatty acids.2015
Author(s)
Horiguchi S, Nakayama K, Iwamoto S, Ishijima A, Minezaki T, Baba M,Kontai Y, Horikawa C, Kawashima H, Shibata H, Kagawa Y, Kawabata T.
Organizer
12th Asian Congress of Nutrition
Place of Presentation
Pacifico Yokohama
Year and Date
2015-05-15
Related Report
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[Presentation] 高齢者の血中脂肪酸組成と脂肪酸不飽和化酵素遺伝子多型との関連,2014
Author(s)
堀口さやか, 石島晶子, 嶺崎隆幸, 馬場眞美子, 金胎芳子, 中山一大, 岩本禎彦, 香川靖雄, 堀川千賀, 河島洋, 柴田浩志, 川端輝江,
Organizer
第68回日本栄養・食糧学会大会
Place of Presentation
札幌市 酪農学園大学
Year and Date
2014-05-30
Related Report
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