| Project/Area Number |
25350980
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Chemical biology
|
|---|
| Research Institution | Daiichi University, College of Pharmaceutical Sciences |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 蛍光センサー / 粘度センサー / 温度センサー / クマリン誘導体 / フェノキサジン誘導体 / 分子ローター / TICT / 蛍光プローブ / 粘度応答性 / 温度応答性 / 近赤外蛍光 / クマリン / 蛍光 / 分子内電荷移動 / Nile Red / 蛍光共鳴エネルギー移動 |
|---|
| Outline of Final Research Achievements |
The viscosity of various liquids is increased if temperature becomes higher, and is decreased if temperature becomes low. If the compound which can output various signals including the color to such a viscous change, can be developed, it can detect the temperature change in the environment, too. In this study, I found that coumarin derivatives can emit the blue fluorescence in response to a viscous change. Based on these results, I applied coumarin derivatives to the use of fluorescence temperature sensor, and could confirm that these derivatives had the excellent characteristics as fluorescence temperature sensors. Furthermore, I succeeded in the development of the fluorescence temperature sensor based on phenoxazin derivatives which can emit the red fluorescence.
|
