| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The building-block methodology employing readily available fluoroalkyl- containing substances plays a prominent role in catalytic asymmetric synthesis of chiral fluoroalkylated compounds. Thus, chiral alpha-fluoroalkylated tertiary alcohols have received increasingly attention in the field of pharmaceutical science. A number of non-steroidal glucocorticoid receptor modulators bearing the chiral alpha-fluoroalkylated tertiary alcohols were found to possess anti-inflammatory effects of a glucocorticoid but with reduced adverse effects, and hence have been searched as potential therapeutics for various inflammatory diseases, such as asthma, rheumatoid arthritis, and allergic rhinitis. In this research, we have succeeded in the development of practical synthetic methods of valuable and multi-functionalized derivatives of chiral alpha-fluoroalkyl substituted tertiary alcohol and these analogues.
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