| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
We have developed the photosensitizers for photodynamic therapy. pH-activatable function has been introduced to tetraphenylporphyrin derivative by using aniline units to suppress photo-induced side effects of photodynamic therapy.
The photosensitization efficiency of the porphyrin with aniline unit was very low in the in the neutral condition (OFF state), but the photosensitization efficiency was recovered in the acidic condition (ON state). Furthermore, the pH-response could be optimized by changing the number of aniline units. A sharp pH-response and high ON/OFF switching ratio were obtained.
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