Development of hard tissue adhesive drug delivery system based on phosphorylated pullulan
| Project/Area Number |
25410228
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Polymer/Textile materials
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| Research Institution | Okayama University |
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Principal Investigator |
OKIHARA Takumi 岡山大学, 自然科学研究科, 講師 (70243491)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | プルラン / 多糖 / リン酸化 / 界面活性剤 / 抗菌剤 / ＤＤＳ / DDS / リン酸化多糖 / カチオン性界面活性剤 / 抗菌作用 / ドラッグデリバリー / リン酸化反応 / ドラッグデリバリーシステム |
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| Outline of Final Research Achievements |
Hard tissue adhesive drug delivery system based on phosphorylated pullulan has developed. Elucidation of the complex formation mechanism and Control of drug release of phosphorylated pullulan and cationic surfactants was reported. Relationship between complex formation and pH, degree of substitution, ionic-strength indicated that neutralization of charge between phosphate group and cation and hydrophobic interaction has important role in complex formation.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Bone engineering by phosphorylated-pullulan and β-TCP composite.2015
Author(s)
Takahata T, Okihara T, Yoshida Y, Yoshihara K, Shiozaki Y, Yoshida A, Yamane K, Watanabe N, Yoshimura M, Nakamura M, Irie M, Van Meerbeek B, Tanaka M, Ozaki T, Matsukawa A.
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Journal Title
Biomed Mater.
Volume: 10
Issue: 6
Pages: 065009-065009
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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