Measurement of blood glucose level by using hollow optical-fiber probe based infrared spectroscopy

• Project/Area Number: 25420311
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Electron device/Electronic equipment
• Research Institution: Tohoku University
• Principal Investigator: KINO SAIKO 東北大学, 医工学研究科, 産学官連携研究員 (30536082)
• Co-Investigator(Kenkyū-buntansha): MATSUURA YUJI 東北大学, 大学院医工学研究科, 教授 (10241530)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 血中グルコース濃度 / 赤外吸収スペクトル / 全反射減衰プリズム / 中空光ファイバ / 全反射プローブ

Outline of Final Research Achievements

A mid-infrared attenuated total reflection (ATR) spectroscopy system employing hollow optical fibers and a trapezoidal multi-reflection ATR prism has been developed to measure blood glucose levels. Using a multi-reflection prism brought about higher sensitivity, and the flat and wide contact surface of the prism resulted in higher measurement reproducibility. An analysis of in vivo measurements of human inner lip mucosa revealed clear signatures of glucose in the difference spectra between ones taken during the fasting state and ones taken after ingestion of glucose solutions. A calibration plot based on the absorption peak at 1155 /cm that originates from the pyranose ring structure of glucose gave measurement errors less than 20%.

Research Products

• [Journal Article] Hollow optical-fiber based infrared spectroscopy for measurement of blood glucose level by using multi-reflection prism (2016)
  • Author(s): Saiko Kino, Suguru Omori, Takashi Katagiri, Yuji Matsuura
  • Journal Title: Biomedical Optics express Volume: ７ Issue: 2 Pages: 701-708
  • DOI: 10.1364/boe.7.000701
  • Peer Reviewed
• [Journal Article] Blood glucose measurement by using hollow optical fiber-based attenuated total reflection probe (2014)
  • Author(s): S. Kino, Y. Tanaka, Y. Matsuura
  • Journal Title: J. Biomedical Opt. Volume: 19 Issue: 5 Pages: 057010-057010
  • DOI: 10.1117/1.jbo.19.5.057010
  • Peer Reviewed / Open Access
• [Presentation] 赤外中空光ファイバプローブを用いた非侵襲血糖値測定 (2016)
  • Author(s): 松浦 祐司，木野 彩子
  • Organizer: 2016年電子情報通信学会総合大会
  • Place of Presentation: 九州大学（福岡）
  • Year and Date: 2016-03-15
• [Presentation] Non-invasive measurement of blood glucose level based on mid-infrared spectroscopy using optical-fiber probe (2016)
  • Author(s): S.Kino, Y. Matsuura
  • Organizer: The Joint Symposium of 10th International Symposium on Medical, Bio- and Nano-Electronics
  • Place of Presentation: Sendai(Japan)
  • Year and Date: 2016-03-02
  • Int'l Joint Research
• [Presentation] Blood glucose measurement in vivo using hollow-fiber based mid-infrared ATR probe with multi-reflection prism (2016)
  • Author(s): S. Kino, S.Omori, Y. Matsuura
  • Organizer: SPIE Conference on Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVI
  • Place of Presentation: San Francisco(USA)
  • Year and Date: 2016-02-12
  • Int'l Joint Research
• [Presentation] 赤外ATRファイバプローブを用いた血糖値インビボ測定 (2016)
  • Author(s): 木野 彩子，松浦 祐司
  • Organizer: レーザー学会学術講演会第36回年次大会
  • Place of Presentation: 名城大学（名古屋）
  • Year and Date: 2016-01-10
• [Presentation] 多重反射型赤外ATRファイバプローブを用いた非侵襲血糖測定 (2015)
  • Author(s): 大森 優, 木野 彩子, 片桐 崇史, 松浦 祐司
  • Organizer: 電気学会光・量子デバイス研究会
  • Place of Presentation: 東北大学東京分室（東京）
  • Year and Date: 2015-03-02
• [Presentation] 多重反射型ATRプリズムを用いた血中グルコース濃度測定 (2015)
  • Author(s): 大森 優, 木野 彩子, 松浦 祐司
  • Organizer: レーザー学会学術講演会第35回年次大会
  • Place of Presentation: 東海大学高輪校舎（品川）
  • Year and Date: 2015-01-11 – 2015-01-12
• [Presentation] 赤外光ファイバATRプローブを用いた血中グルコース濃度測定 ―多重反射ATRプリズムによる感度向上― (2014)
  • Author(s): 大森 優，木野彩子，松浦祐司
  • Organizer: 第61回応用物理学会春季学術講演会
  • Place of Presentation: 相模原
• [Presentation] ヨウ化銀内装中空光ファイバを用いた赤外ATR分光測定 (2013)
  • Author(s): 大森 優, 木野彩子, 松浦 祐司
  • Organizer: 平成25年度電気関係学会東北支部連合大会
  • Place of Presentation: 会津
• [Patent(Industrial Property Rights)] 赤外分光法を用いた非侵襲血糖値測定方法 (2016)
  • Inventor(s): 松浦 祐司，木野 彩子
  • Industrial Property Rights Holder: 松浦 祐司，木野 彩子
  • Industrial Property Rights Type: 特許
  • Filing Date: 2016-02-09