Molecular role of RNF43 in Wnt signaling and tumorigenesis
| Project/Area Number |
25430102
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
Hatakeyama Shigetsugu 北海道大学, 大学院医学研究科, 教授 (70294973)
Takahashi Hidehisa 北海道大学, 大学院医学研究科, 講師 (30423544)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | Wnt / RNF43 / Fzd / Dvl / ubiquitin / tumorigenesis / シグナル / がん / 翻訳後修飾 / ユビキチン / p53 / エンドサイトーシス / 細胞極性 |
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| Outline of Final Research Achievements |
Wnt signaling pathways are tightly regulated by ubiquitination of their signal transducers and dysregulation of these pathways promotes the tumorigenesis. It has been reported that an ubiquitin ligase RNF43 plays important role in the Fzd-dependent regulation of Wnt signaling pathways. We recently reported that N-terminal of RNF43 is indespensable to regulate Fzd-dependent suppression of Wnt signaling pathways although C-terminal of RNF43 is able to inhibit noncanonical Wnt signaling in a Fzd-independent but Dvl-dependent fashion. In addition missense mutations found in cancer patients convert the function of RNF43 to the positive regulator of Wnt/βcatenin signaling and establish a positive feedback loop of Wnt/βcatenin signaling to accelerate tumorigenesis. These results have been published in a scientific journal [ Tsukiyama, MCB, 35:2007 (2015)].
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] The inflammatory cytokine IL-1b is involved in bladder remodeling after bladder outlet obstruction in mice2015
Author(s)
Kanno, Y., Mitsui, T., Kitta, T., Moriya, K., Tsukiyama, T., Hatakeyama, S. and Nonomura, K.
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Journal Title
Neurouro. Urodyn.
Volume: 未定
Issue: 3
Pages: 277-381
DOI
Related Report
Peer Reviewed
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[Journal Article] MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex2015
Author(s)
Takahashi, H., Takigawa, I., Watanabe, M., Anwar, D., Shibata, M., Tomomori-Sato, C., Sato, S., Ranjan, A., Seidel, C.W., Tsukiyama, T., Mizushima, W., Hayashi, M., Ohkawa, Y., Conaway, J.W., Conaway, R.C. and Hatakeyama, S
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Journal Title
Nature Commun.
Volume: 5
Issue: 1
Pages: 5941-5941
DOI
NAID
Related Report
Peer Reviewed / Open Access
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