Analysis of inflammation and immune cells in tumor microenvironment.
| Project/Area Number |
25430103
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Tohoku University |
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Principal Investigator |
Shirota Hidekazu 東北大学, 医学(系)研究科(研究院), 講師 (50451555)
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| Co-Investigator(Kenkyū-buntansha) |
Ito Hiroyasu 岐阜大学, 医学系研究科, 准教授 (80373075)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 腫瘍免疫 / 腫瘍微小環境 / T細胞 / マクロファージ / MDSC / 腫瘍 / 微小環境 / 癌免疫 |
|---|
| Outline of Final Research Achievements |
Tumor infiltrate leukocytes play an important role in tumor growth and metastasis. This study focused on these cells, examining tumor inflammation and classified the pattern of inflammation in colon cancer and clarified a role in tumor promotion. For example, (1) There are three classes of inflammation in colon cancer, due to a difference of tumor infiltrate leukocyte and cytokines. (2) We have reported that murine mMDSC express TLR9 and respond to stimulation by the TLR9 agonist CpG oligodeoxynucleotide (ODN) by differentiating into tumoricidal macrophages and human mMDSC respond to TLR7/8 agonists to differentiate into tumoricidal M1-like macrophages.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Efficacy and Safety Assessment of Paclitaxel in Patients with Docetaxel-Resistant Esophageal Squamous Cell Carcinoma.2016
Author(s)
Imai H, Komine K, Takahashi S, Saijo K, Okada Y, Kobayashi A, Okita A, Chikamatsu S, Kasahara Y, Takahashi M, Oishi T, Shirota H, Takahashi M, Shimodaira H, Ishioka C
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Journal Title
Chemotherapy
Volume: 61（5）
Pages: 262-268
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Attainment of a Long-term Favorable Outcome by Sunitinib Treatment for Pancreatic Neuroendocrine Tumor and Renal Cell Carcinoma Associated with von Hippel-Lindau Disease2016
Author(s)
Kobayashi A, Takahashi M, Imai H, Akiyama S, Sugiyama S, Komine K, Saijo K, Takahashi M, Takahashi S, Shirota H, Sato N, Fujishima F, Shuin T, Shimodaira H, Ishioka C.
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Journal Title
Internal Medicine
Volume: 55
Issue: 6
Pages: 629-634
DOI
NAID
ISSN
0918-2918, 1349-7235
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] IFN-gamma AU-rich element removal promotes chronic IFN-gamma expression and autoimmunity in mice.2014
Author(s)
Hodge DL, Berthet C, Coppola V, Kastenmüller W, Buschman MD, Schaughency PM, Shirota H, Scarzello AJ, Subleski JJ, Anver MR, Ortaldo JR, Lin F, Reynolds DA, Sanford ME, Kaldis P, Tessarollo L, Klinman DM, Young HA.
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Journal Title
J Autoimmun.
Volume: 53
Pages: 33-45
Related Report
Peer Reviewed
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[Journal Article] β-Defensin 2 and 3 Promote the Uptake of Self or CpG DNA, Enhance IFN-α Production by Human Plasmacytoid Dendritic Cells, and Promote Inflammation.2013
Author(s)
Tewary P, de la Rosa G, Sharma N, Rodriguez LG, Tarasov SG, Howard OM, Shirota H, Steinhagen F, Klinman DM, Yang D, Oppenheim JJ.
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Journal Title
J Immunol.
Volume: 191(2)
Issue: 2
Pages: 865-874
DOI
Related Report
Peer Reviewed
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