Analysis of the regulatory mechanisms of the actin cytoskeleton in invadopodia formation by cancer cells
| Project/Area Number |
25430126
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | National Cancer Center Japan |
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Principal Investigator |
Yamaguchi Hideki 国立研究開発法人国立がん研究センター, 研究所, ユニット長 (10345035)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 浸潤突起 / アクチニン / がん浸潤 / 浸潤転移 |
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| Outline of Final Research Achievements |
Invadopodia are membrane protrusions formed by invasive cancer cells that contain bundled actin filaments and mediate degradation of the extracellular matrix. Invadopodia are thought to promote cancer invasion. In this study, the function of actinin-4, an actin bundling protein implicated in cancer progression, in invadopodia formation was investigated. Actinin-4 localized at invadopodia and was required for the formation of actin structures and the extracellular matrix degradation activity of invadopodia. Overexpression of actinin-4 enhanced invadopodia formation and this activity required the actin bundling activity. These results indicate that actinin-4 bundles actin filaments at invadopodia and plays an important role in cancer invasion and metastasis.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Flotillin-1 regulates oncogenic signaling in neuroblastoma cells by regulating ALK membrane association.2014
Author(s)
Tomiyama A, Uekita T, Kamata R, Sasaki K, Takita J, Ohira M, Nakagawara A, Kitanaka C, Mori K, Yamaguchi H, Sakai R.
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Journal Title
Cancer Res.
Volume: 74(14)
Issue: 14
Pages: 3790-3801
DOI
Related Report
Peer Reviewed / Open Access
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