| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The regulation of RNA granule assembly and disassembly is a structural basis of translational control. Here, we analyzed the mechanism of RNA granule assembly and disassembly regulated by NFAR2-NF45 complex and RNA granule disassembly regulated by PRMT1. NFAR2 enhanced the assembly of RNA granules, whereas NF45 promoted disassembly of RNA granules by binding to NFAR2 and inhibiting the ability of NFAR2 to assemble RNA granules. PRMT1 methylated RNG105, which reduced the ability of RNG105 to promote RNA granule assembly and resulted in the disassembly of RNA granules. These results provided novel mechanisms of assembly and disassembly of RNA granules.
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