Diversity of intercellular transfer of melanosomes
| Project/Area Number |
25440105
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 細胞間輸送 / メラニン色素 / 色素細胞 / 表皮細胞 / メラノサイト / ケラチノサイト / メラニン / 色素輸送 |
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| Outline of Final Research Achievements |
Skin pigmentation is achieved through an intercellular transfer of melanin pigments from melanocytes to surrounding keratinocytes. Our live imaging has visualized that the melanosomes are transferred via three pathways, membrane vesicles (small vesicles), filopodia and large vesicles. In this study, we attempted to understand molecular mechanisms and diversity of melanosome transfer. We first clarified that small GTPase Rho regulates membrane vesicles (small vesicles) by several different experiments. Second, we have identified keratinocyte-derived molecule that induce vesicle generation, especially larger vesicles. Finally, to understand conservation and diversity of intercellular transfer, we have examined extracellular vesicles from tumor cells during metastasis.
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Report
(5 results)
Research Products
(14 results)
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[Journal Article] Melanosome transfer to keratinocyte in the chicken embryonic skin is mediated by vesicle release associated with Rho-regulated membrane blebbing.2016
Author(s)
Tadokoro, R., Murai, H., Sakai, K., Okui, T, Yokota, Y., Takahashi, Y.
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Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 38277-38277
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Angiogenesis in the developing spinal cord: Blood vessel exclusion from neural progenitor region is mediated by VEGF and its antagonists.2014
Author(s)
Takahashi, T., Takase, Y., Yoshino, T., Saito, D., Tadokoro, R. and *Takahashi, Y.
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Journal Title
PLOS ONE
Volume: 10(1)
Issue: 1
Pages: e0116119-e0116119
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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