| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The dynamic change of higher microtubule structures is effected by not only a cell cycle control but also several environmental stimulus. PHS1 is involved in microtubule formation or maintenance. When plant cells are given by the hyper osmotic stress, alpha-tubulins are phosphorylated, resulting into promoting microtubule depolymerization. In this study, it was elucidated that Thr349 of alpha-tubulin is the target of PHS1. Next, we isolated the fifteen phosphorylation sites that response to the hyper osmotic stimulus. Moreover, it is suggested that the microtubule depolymerization via PHS1 is related with induction of the M-phase check point, and it is important for safely segregating of chromosomes in the dividing cell under hyper osmotic stress.
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