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ESR study of synergistic effects on radical scavenging capacities in the presence of various antioxidants

Research Project

Project/Area Number 25450169
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Food science
Research InstitutionOkayama University

Principal Investigator

Sueishi Yoshimi  岡山大学, 自然科学研究科, 教授 (50135935)

Research Collaborator KOTAKE Yashige  
OOWADA Shigeru  
INAZUMI Naoya  
SHIMMEI Masashi  
ENDOU Nobuyuki  
UKAI Mitsuko  
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords抗酸化物質 / 相乗・相殺効果 / スピントラップ / 活性種消去
Outline of Final Research Achievements

In foods, antioxidants exist independently. Judging from the evaluation of the antioxidant’s activities in the presence of two antioxidants, the synergistic effect between antioxidants is operative. However, the mechanism of the synergistic effects has not been established yet. In this study, by using ESR spin trapping method, various active species scavenging abilities of antioxidants (drug and food) were measured. Based on the results, the mechanism of the synergistic effects for antioxidant abilities was discussed.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (17 results)

All 2015 2014 2013 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Acknowledgement Compliant: 2 results) Presentation (12 results) (of which Invited: 1 results)

  • [Journal Article] Kinetic Evaluation of Spin Trapping Rate Constants of New CYPMPO-type Spin Traps for Superoxide and Other Free Radicals2015

    • Author(s)
      Y. Sueishi, E. Kamogawa, H. Nakamura, M. Ukai, M. Kunieda, T. Okada, M. Shimmei, and Y. Kotake
    • Journal Title

      Z. Phys. Chem.

      Volume: 229 Issue: 3 Pages: 317-326

    • DOI

      10.1515/zpch-2014-0610

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Evaluation of Scavenging Rate Constants of DOPA and Tyrosine Enantiomers against Multiple Reactive Oxygen Species and Methyl Radical as Measured with ESR Trapping Method2015

    • Author(s)
      Y. Sueishi and T. Takemoto
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 25 Issue: 8 Pages: 00-00

    • DOI

      10.1016/j.bmcl.2014.12.017

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effects of Substituent and External Pressure on Spin Trapping Rates of Carbon Dioxide Anion, Sulfur Trioxide Anion, Hydroxyl, and Ethyl Radicals with Various PBN- and DMPO-Type Spin Traps2014

    • Author(s)
      Y. Sueishi, K. Miyazono, and K. Kozai
    • Journal Title

      Z. Phys. Chem.

      Volume: 228 Issue: 9 Pages: 927-938

    • DOI

      10.1515/zpch-2014-0538

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Scavenging rate constants of hydrophilic antioxidants against multiple reactive oxygen species2014

    • Author(s)
      Y. Sueishi, M. Hori, M. Ishikawa, K. Matsu-ura, E. Kamogawa, Y. Honda, M. Kita, K. Ohara
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 54 Issue: 2 Pages: 67-74

    • DOI

      10.3164/jcbn.13-53

    • NAID

      130004879353

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A multiple Free-Radical Scavenging (MULTIS) Study on the Antioxidant Capacity of a Neuroprotective Drug, Edaravone as Compared with Uric Acid, Glutathione, and Trolox2014

    • Author(s)
      E. Kamogawa and Y. Sueishi
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 24 Issue: 5 Pages: 1376-1379

    • DOI

      10.1016/j.bmcl.2014.01.045

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] シソおよびバジル抽出液(水溶性および脂溶性成分) のESR 法による抗酸化能評価2015

    • Author(s)
      須江美里,末石芳巳
    • Organizer
      2015年日本化学会中国四国支部大会
    • Place of Presentation
      岡山大学(岡山市)
    • Year and Date
      2015-11-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] ESRトラップ法を用いたフラボノイド類の抗酸化能評価およびその構造が及ぼす抗酸化能力への影響2015

    • Author(s)
      柿崎成,末石芳巳
    • Organizer
      2015年日本化学会中国四国支部大会
    • Place of Presentation
      岡山大学(岡山市)
    • Year and Date
      2015-11-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] スピントラップ法によるローズマリー抽出液(水溶性および脂溶性性成分)の抗酸化能評価2015

    • Author(s)
      須江美里,末石芳巳
    • Organizer
      第68回日本酸化ストレス学会学術集会
    • Place of Presentation
      かごしま県民センター(鹿児島市)
    • Year and Date
      2015-06-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] ESRスピントラップ法によるヒト血清の抗酸化物質における多重活性種消去能(MULTIS法)評価2015

    • Author(s)
      鴨川英莉沙,末石芳巳
    • Organizer
      第68回日本酸化ストレス学会学術集会
    • Place of Presentation
      かごしま県民センター(鹿児島市)
    • Year and Date
      2015-06-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] スーパーオキサイドなどのフリーラジカルに対する新規 CYPMPO 型スピントラップ誘導体のスピントラップ速度定数の速度論的決定2014

    • Author(s)
      鴨川英莉沙,末石芳巳,真明正志,古武弥成
    • Organizer
      2014年日本化学会中国四国支部大会
    • Place of Presentation
      山口大学(山口市)
    • Year and Date
      2014-11-08 – 2014-11-09
    • Related Report
      2014 Research-status Report
  • [Presentation] スピントラップ法によるシソおよびバジル抽出液の抗酸化能評価2014

    • Author(s)
      須江美里,末石芳巳
    • Organizer
      2014年日本化学会中国四国支部大会
    • Place of Presentation
      山口大学(山口市)
    • Year and Date
      2014-11-08 – 2014-11-09
    • Related Report
      2014 Research-status Report
  • [Presentation] 多重血清種消去能決定法によるローズマリー抽出液の抗酸化能評価法の構築2014

    • Author(s)
      須江美里,末石芳巳
    • Organizer
      第67回日本酸化ストレス学会学術集会
    • Place of Presentation
      同志社大学(京都市)
    • Year and Date
      2014-09-04 – 2014-09-05
    • Related Report
      2014 Research-status Report
  • [Presentation] ESRスピンとラッピング法によるウシ血清タンパク質における多重活性種(MULTIS法)の消去能評価2014

    • Author(s)
      鴨川英莉沙,末石芳巳
    • Organizer
      第67回日本酸化ストレス学会学術集会
    • Place of Presentation
      同志社大学(京都市)
    • Year and Date
      2014-09-04 – 2014-09-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 多重活性種消去能決定法(MULTIS法)によるウシ血清の活性種消去能評価2013

    • Author(s)
      鴨川英莉沙,末石芳巳,木村杏奈,菅野信之,北原豪,佐藤裕之,浅沼武敏,古武弥成
    • Organizer
      第66回日本酸化ストレス学会学術集会
    • Place of Presentation
      ウインクあいち(名古屋市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 幾つかの抗酸化物質共存下での相乗的活性種消去能の解明2013

    • Author(s)
      寺本宗之助,末石芳巳
    • Organizer
      第52回電子スピンサイエンス学会年会
    • Place of Presentation
      大宮ソニックシティ(さいたま市)
    • Related Report
      2013 Research-status Report
  • [Presentation] ラジカル消去剤として用いられているエダラボンの様々な活性種の消去能評価2013

    • Author(s)
      鴨川英莉沙,末石芳巳,古武弥成
    • Organizer
      第52回電子スピンサイエンス学会年会
    • Place of Presentation
      大宮ソニックシティ(さいたま市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 多重活性種消去能決定法による活性種消去能評価

    • Author(s)
      鴨川英莉沙,末石芳巳
    • Organizer
      第1回Multiple Free-Radical Scavenging Capacity 研究会
    • Place of Presentation
      同志社大学(京都市)
    • Related Report
      2013 Research-status Report
    • Invited

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Published: 2014-07-25   Modified: 2019-07-29  

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