| Project/Area Number |
25460030
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HORIKAWA MITSUYO 徳島文理大学, 大学院薬学研究科, 助教 (50148772)
KAKU HIROTO 徳島文理大学, 大学院薬学研究科, 準教授 (90299339)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 新光延試薬 / 不斉分子認識 / デラセミ化 / アブラムシ色素 / 不斉全合成 / 炭素-窒素形成反応 / デラセミ化法 / 不斉アザクライゼン転位 / 生体防御物質 / 新しい光延試薬 / ホスト分子 / アブラムシ / ポリケタイド系色素 / 昆虫病原菌 / 新光延反応 / 炭素ー窒素結合形成反応 / スルホンアミド / ホスト，ゲスト化学 / 全合成 |
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| Outline of Final Research Achievements |
We developed efficient method to convert molecular structure utilizing new Mitsunobu reaction and kinetic molecular recognition. For example, the use of host molecule with alkaline converted racemic 3-benzy-2-hexanone and to the S-isomer of 99% ee in 93% yield. Furthermore, new Mitsunobu reagents such as CMBP and CMMP prepared were mediated C-C and C-N forming reaction in excellent yield. Utilizing these new reaction, we synthesized polyketide pigments of aphid.
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