Analysis of activation of cellular immunity through intestinal immunity to develop versatile oral adjuvants for treatment of viral infection.
| Project/Area Number |
25460183
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | Kyushu University of Health and Welfare |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE wataru 九州保健福祉大学, 大学院医療薬学研究科, 教授 (50399218)
YOSHIDA hiroki 九州保健福祉大学, 大学院医療薬学研究科, 講師 (90469411)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 細胞性免疫 / 腸管免疫 / 経口アジュバント / プロポリス / モリンガ葉 / 乳酸菌 / 単純ヘルペスウイルス / 遅延型過敏反応 / Th1サイトカイン / ウイルス感染 / パイエル板 |
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| Outline of Final Research Achievements |
Our aim in this project is to search oral antigens that are able to activate cellular immunity through intestinal immunity and clarify the mode of the activation. It is known that a major immune defense system in intradermally herpes simplex virus-infected mice is a delayed type hypersensitivity reaction through Th1 immunity. Using this model, we demonstrated that Lactobacillus plantarum strain 06CC2 and aqueous extract of Moringa oleifera Lam. leaves (AqMOL) as well as propolis AF-08 that we found previously were significantly effective in alleviating herpetic symptoms by the activation of Th1 immunity through intestinal immunity. Thus, the three daily supplements, 06CC2, AqMOL, and AF-08 were suggested to be useful as a versatile oral adjuvant for treatment of viral infection.
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Report
(4 results)
Research Products
(83 results)
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[Journal Article] nhibitory effects of compounds isolated from the dried branches and leaves of murta (Myrceugenia euosma) on lipid accumulation in 3T3-L1 cells.2016
Author(s)
Oikawa, N., Nobushi, Y., Wada, T., Sonoda, K., Okazaki, Y., Tsutsumi, S., Park, Y. K., Kurokawa, M., Shimba, S., Yasukawa, K.
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Journal Title
J. Nat. Med.
Volume: 印刷中
Issue: 3
Pages: 502-509
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Titanium dioxide nanoparticles exacerbate pneumonia in respiratory syncytial virus (RSV)-infected mice.2015
Author(s)
1)Hashiguchi S, Yoshida H, Akashi T, Komemoto K, Ueda T, Ikarashi Y, Miyauchi A, Konno K, Yamanaka S, Hirose A, Kurokowa M, Watanabe W.
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Journal Title
Environ Toxicol Pharmacol
Volume: 39
Pages: 879-886
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Citrus flavonoid naringenin inhibits TLR2 expression in adipocytes.2013
Author(s)
Yoshida, H., Watanabe, W., Oomagari, H., Tsuruta, E., Shida, M., Kurokawa, M.
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Journal Title
Journal of Nutritional Biochemistry
Volume: 24
Pages: 1276-1284
Related Report
Peer Reviewed
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[Journal Article] Effect of oral administration of probiotics from Mongolian dairy products on Th1 immune response in mice.2013
Author(s)
Takeda, S., Kawahara, S., Hidaka, M., Yoshida, H., Watanabe, W., Takeshita, M., Kikuchi, Y., Bumbein, D., Muguruma, M., and Kurokawa, M.
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Journal Title
Biosci. Biotechnol. Biochem.
Volume: 77
Pages: 1372-1378
Related Report
Peer Reviewed
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[Journal Article] Antiviral activity of diarylheptanoid stereoisomers against respiratory syncytial virus in vitro and in vivo.2013
Author(s)
Konno, K., Sawamura, R., Miura, M., Toriyama, M., Motohashi, S., Yasukawa, K., Watanabe, W., Yoshida, H., Kato, M., Yamamoto, R., and Kurokawa, M.
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Journal Title
J. Nat. Med.
Volume: 67
Pages: 773-781
Related Report
Peer Reviewed
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[Journal Article] Corticosteroids plus long-acting beta2-agonists prevent double-stranded RNA-induced upregulation of B7-H1 on airway epithelium.2013
Author(s)
Kan-o, K., Matsumoto, K., Inoue, H., Fukuyama, S., Asai, Y., Watanabe, W., Kurokawa, M., Araya, J., Kuwano, K., Nakanishi, Y.
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Journal Title
Int. Arch. Allergy. Immunol.
Volume: 160
Pages: 27-36
Related Report
Peer Reviewed
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[Journal Article] Perinatal exposure to insecticide methamidophos suppressed production of proinflammatory cytokines responding to virus infection in lung tissues in mice.2013
Author(s)
Watanabe,W., Yoshida, H., Hirose, A., Akashi, T., Takeshita, T., Kuroki, N., Shibata, A., Hongo, S., Hashiguchi, S., Konno, K., Kurokawa, M.
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Journal Title
BioMed. Res. Int.
Volume: 0
Pages: 151807-151814
DOI
Related Report
Peer Reviewed
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[Journal Article] Effect of Brazilian propolis on exacerbation of respiratory syncytial virus infection in mice exposed to tetrabromobisphenol A, a brominated flame retardant.2013
Author(s)
Takeshita, T., Watanabe, W., Toyama, S., Hayashi, Y., Honda, S., Sakamoto, S., Matsuoka, S., Yoshida, H., Takeda, S., Hidaka, M., Tsutsumi, S., Yasukawa, K., Park, Y. K., Kurokawa, M.
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Journal Title
Evid. Based. Complement. Alternat. Med.
Volume: 2013
Pages: 1-6
Related Report
Peer Reviewed
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