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Immunohistochemical evaluation of mitochondrial quality control in vivo

Research Project

Project/Area Number 25460276
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General anatomy (including histology/embryology)
Research InstitutionJuntendo University

Principal Investigator

Koike Masato  順天堂大学, 医学(系)研究科(研究院), 教授 (80347210)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsミトコンドリア / マイトファジー / リソソーム / parkin / オメガソーム / DFCP1 / パーキンソン病 / MPTP / 収束イオンビーム搭載走査型電子顕微鏡 / IRP2 / Parkin / 黒質 / 粗面小胞体 / オートファジー / カテプシンD / サブユニットc
Outline of Final Research Achievements

1. Lysosomal accumulation of mitochondrial subunit c in cathepsin D (CD) deficient neurons were completely inhibited in neurons doubly deficient in CD and Atg7 and only partially reduced in neurons doubly deficient in CD and parkin, indicating the limited contribution of mitophagy mediated by parkin in the mitochondrial quality control in neurons. 2. Intercrossing of the transgenic (Tg) mice expressing iron regulatory protein 2 (IRP2) to Parkin knockout mice perturbed the integrity of neurons specifically in the substantia nigra and provoked motor symptoms. 3. Therefore, we produced antibodies specific to mouse DFCP1, a marker for omegasomes. In HeLa cells under normal conditions, dotted or tubular immunoreactivity for DFCP1 was found along Tom20-positive mitochondria. Moreover, under starved conditions, DFCP1-positive structures were co-localized in one part of the LC3-positive autophagosomes.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (68 results)

All 2016 2015 2014 2013 Other

All Int'l Joint Research (1 results) Journal Article (23 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 23 results,  Open Access: 14 results,  Acknowledgement Compliant: 4 results) Presentation (41 results) (of which Int'l Joint Research: 1 results,  Invited: 4 results) Book (1 results) Remarks (2 results)

  • [Int'l Joint Research] ユトレヒト大学医学部(オランダ)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Neuroprotection by selective neuronal deletion of autophagy-related gene ATG7 in neonatal brain injury2016

    • Author(s)
      Xie, C., Ginet, V., Sun, Y., Koike, M., Zhou, K., Li, T., Li, H., Li, Q., Wang, X., Uchiyama, Y., Truttmann, AC., Kroemer, G., Puyal, J., Blomgren, K., Zhu, C
    • Journal Title

      Autophagy

      Volume: 12 Issue: 2 Pages: 410-423

    • DOI

      10.1080/15548627.2015.1132134

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The ablation of mitochondrial protein phosphatase pgam5 confers resistance against metabolic stress2016

    • Author(s)
      Sekine S., Yao, A., Hattori, K., Sugawara, S., Naguro, I., Koike, M., Uchiyama, Y., Takeda, K., Ichijo, H
    • Journal Title

      EBioMedicine

      Volume: 6 Pages: 82-92

    • DOI

      10.1016/j.ebiom.2016.01.031

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] <b>A specific tripeptidyl substrate for tripeptidyl peptidase activity is effectively hydrolyzed by alanyl aminopeptidase/</b><b>aminopeptidase N/CD13 in the rat kidney </b>2016

    • Author(s)
      Shibata, M., Koike, M., Kusumi, S., Sato, N., Uchiyama, Y
    • Journal Title

      Archives of Histology and Cytology

      Volume: 76 Issue: 1 Pages: 1-8

    • DOI

      10.1679/aohc.76.1

    • NAID

      130005131324

    • ISSN
      0914-9465, 1349-1717
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Macroautophagy is essential for killing of intracellular Burkholderia pseudomallei in human neutrophils.2015

    • Author(s)
      Rinchai D, Riyapa D, Buddhisa S, Utispan K, Titball RW, Stevens MP, Stevens JM, Ogawa M, Tanida I, Koike M, Uchiyama Y, Ato M, Lertmemongkolchai G.
    • Journal Title

      Autophagy

      Volume: 11 Issue: 5 Pages: 748-755

    • DOI

      10.1080/15548627.2015.1040969

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] VPS29-VPS35 intermediate of retromer is stable and may be involved in the retromer complex assembly process.2015

    • Author(s)
      Fuse A, Furuya N, Kakuta S, Inose A, Sato M, Koike M, Saiki S, Hattori N
    • Journal Title

      FEBS Lett.

      Volume: 589 Issue: 13 Pages: 1430-1436

    • DOI

      10.1016/j.febslet.2015.04.040

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Human herpesvirus 6A U14 is important for virus maturation.2015

    • Author(s)
      Mori, J., Tang, H., Kawabata, A., Koike, M., Mori, Y
    • Journal Title

      J Virol

      Volume: 90 Issue: 3 Pages: 1677-1681

    • DOI

      10.1128/jvi.02492-15

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ethambutol neutralizes lysosomes and causes lysosomal zinc accumulation.2015

    • Author(s)
      Yamada D, Saiki S, Furuya N, Ishikawa K, Imamichi Y, Kambe T, Fujimura T, Ueno T, Koike M, Sumiyoshi K, Hattori N
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 471 Issue: 1 Pages: 109-116

    • DOI

      10.1016/j.bbrc.2016.01.171

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] L-carnitine enhances axonal plasticity and improves white-matter lesions after chronic hypoperfusion in rat brain.2015

    • Author(s)
      Ueno Y, Koike M, Shimada Y, Shimura H, Hira K, Tanaka R, Uchiyama Y, Hattori N, Urabe T.
    • Journal Title

      J Cereb Blood Flow Metab

      Volume: 35 Issue: 3 Pages: 382-91

    • DOI

      10.1038/jcbfm.2014.210

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Target- and input-dependent organization of AMPA and NMDA receptors in synaptic connections of the cochlear nucleus2015

    • Author(s)
      Rubio ME, Fukazawa Y, Kamasawa N, Clarkson C, Molnar E, Shigemoto R
    • Journal Title

      J Comp Neurol

      Volume: 588 Pages: 29-35

    • DOI

      10.1016/j.neulet.2014.12.052

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] EFA6A, a gunanine nucleotide exchange factor for Arf6, interacts with sorting nexin-1 and regulates neurite outgrowth2015

    • Author(s)
      Fukaya M, Fukushima D, Hara Y, Sakagami H.
    • Journal Title

      J. Neurochem.

      Volume: 4 Issue: 3 Pages: 360-73

    • DOI

      10.1016/j.stemcr.2015.01.006

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Viable neuronopathic Gaucher disease model in medaka (Oryzias latipes) displays axonal accumulation of alpha-synuclein2015

    • Author(s)
      Norihito Uemura, Masato Koike, Satoshi Ansai, Masato Kinoshita, Tomoko Ishikawa-Fujiwara, Hideaki Matsui, Kiyoshi Naruse, Naoaki Sakamoto, Yasuo Uchiyama, Takeshi Todo, Shunichi Takeda, Hodaka Yamakado, Ryosuke Takahashi
    • Journal Title

      PLoS Genetics

      Volume: 11 Issue: 4 Pages: 1-14

    • DOI

      10.1371/journal.pgen.1005065

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] <b>Cellular localization and tissue distribution of endogenous DFCP1 pr</b><b>otein </b>2015

    • Author(s)
      Nanao T, Koike M, Yamaguchi J, Sasaki M, Uchiyama Y.
    • Journal Title

      Biomedical Research

      Volume: 36 Issue: 2 Pages: 121-133

    • DOI

      10.2220/biomedres.36.121

    • NAID

      130005065279

    • ISSN
      0388-6107, 1880-313X
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Three-dimensional architecture of podocytes revealed by block-face scanning electron microscopy.2015

    • Author(s)
      Ichimura K, Miyazaki N, Sadayama S, Murata K, Koike M, Nakamura K, Ohta K, Sakai T
    • Journal Title

      Sci Rep.

      Volume: 5 Issue: 1 Pages: 8993-8993

    • DOI

      10.1038/srep08993

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pancreatic β cell failure mediated by mTORC1 hyperactivity and autophagic impairment.2014

    • Author(s)
      Bartolome A, Kimura-Koyanagi M, Asahara SI, Guillen C, Inoue H, Teruyama K, Shimizu S, Kanno A, Garcia-Aguilar A, Koike M, Uchiyama Y, Benito M, Noda T, Kido Y
    • Journal Title

      Diabetes

      Volume: 未定 Issue: 9 Pages: 2996-3008

    • DOI

      10.2337/db13-0970

    • NAID

      40020504710

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increased immunoreactivity of cathepsins in the rat esophagus under chronic acid reflux esophagitis.2014

    • Author(s)
      Suyama M, Koike M, Asaoka D, Mori H, Oguro M, Ueno T, Nagahara A, Watanabe S, Uchiyama Y.
    • Journal Title

      J Histochem Cytochem

      Volume: 62 Issue: 9 Pages: 645-60

    • DOI

      10.1369/0022155414542300

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] P150glued-associated disorders are caused by activation of intrinsic apoptotic pathway.2014

    • Author(s)
      Ishikawa K, Saiki S, Furuya N, Yamada D, Imamichi Y, Li Y, Kawajiri S, Sasaki H, Koike M, Tsuboi Y, Hattori N.
    • Journal Title

      PLoS One.

      Volume: 9 Issue: 4 Pages: e94645-e94645

    • DOI

      10.1371/journal.pone.0094645

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Human IAPP-induced pancreatic β cell toxicity and its regulation by autophagy.2014

    • Author(s)
      Shigihara N, Fukunaka A, Hara A, Komiya K, Honda A, Uchida T, Abe H, Toyofuku Y, Tamaki M, Ogihara T, Miyatsuka T, Hiddinga HJ, Sakagashira S, Koike M, Uchiyama Y, Yoshimori T, Eberhardt NL, Fujitani Y, Watada H.
    • Journal Title

      J Clin Invest.

      Volume: 124 Issue: 8 Pages: 3634-44

    • DOI

      10.1172/jci69866

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nitric oxide-mediated injury of interstitial cells of Cajal and intestinal dysmotility under endotoxemia of mice.2014

    • Author(s)
      Ueshima S, Nishida T, Koike M, Matsuda H, Sawa Y, Uchiyama Y.
    • Journal Title

      Biomed Res

      Volume: 35 Pages: 251-62

    • NAID

      130004678581

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] NF-Y inactivation causes atypical neurodegeneration characterized by ubiquitin and p62 accumulation and endoplasmic reticulum disorganization2014

    • Author(s)
      Yamanaka, T., Tosaki, A., Kurosawa, M., Matsumoto, G., Koike, M., Uchiyama, Y., Maity, S.N., Shimogori, T., Hattori, N. & Nukina, N.
    • Journal Title

      Nat. Commun.

      Volume: 5 Issue: 1 Pages: 3354-3354

    • DOI

      10.1038/ncomms4354

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Enrichment of GABARAP relative to LC3 in the axonal initial segments of neurons2013

    • Author(s)
      Koike M, Tanida I, Nanao T, Tada N, Iwata J, Ueno T, Kominami E, Uchiyama Y.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 5 Pages: e63568-e63568

    • DOI

      10.1371/journal.pone.0063568

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tuberin activates and controls the distribution of Rac1 via association with p62 and ubiquitin through the mTORC1 signaling pathway.2013

    • Author(s)
      Okura, H., Kobayashi, T., Koike, M., Ohsawa, M., Zhang, D., Arai, H., Uchiyama, Y., *Hino O
    • Journal Title

      Int J Oncol

      Volume: 43 Issue: 2 Pages: 447-456

    • DOI

      10.3892/ijo.2013.1984

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Exendin-4 improves β-cell function in autophagy-deficient β-cells.2013

    • Author(s)
      Abe H, Uchida T, Hara A, Mizukami H, Komiya K, Koike M, Shigihara N, Toyofuku
    • Journal Title

      Endocrinology

      Volume: 154 Issue: 12 Pages: 4512-24

    • DOI

      10.1210/en.2013-1578

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Local apoptosis modulates early mammalian brain development through the elimination of morphogen producing cells.2013

    • Author(s)
      Nonomura, K., Yamaguchi, Y., Hamachi, M., Koike, M., Uchiyama, Y., Nakazato, K., Mochizuki, A., Sakaue-Sawano, A., Miyawaki, A., Yoshida, H., Kuida, K., and Miura, M.
    • Journal Title

      Dev. Cell

      Volume: 27 Issue: 6 Pages: 621-634

    • DOI

      10.1016/j.devcel.2013.11.015

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Cellular localization and tissue distribution of endogenous DFCP1 protein2016

    • Author(s)
      Koike, M., Nanao, T., Yamaguchi, J., Sasaki, M., Uchiyama, Y
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      ビッグパレットふくしま(福島県郡山市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] オリゴデンドロサイト分化における mTORC1活性化の意義2016

    • Author(s)
      砂堀毅彦、名田茂之、岡田雅人、内山安男、小池正人
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      ビッグパレットふくしま(福島県郡山市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 糸球体足細胞における突起とスリット膜の発生過程2016

    • Author(s)
      市村浩一郎、角田宗一郎、川崎優人、小池正人、坂井建雄
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      ビッグパレットふくしま(福島県郡山市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] ゴルジ体の形成異常に起因する神経病態発症機序の解明2016

    • Author(s)
      曽高友深、角田宗一郎、前田祐輔、木下タロウ、渡辺雅彦、崎村建司、内山安男、小池正人
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      ビッグパレットふくしま(福島県郡山市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 類鼻疽菌に感染した好中球に誘導されるオートファジー関連構造体についての解析2016

    • Author(s)
      谷田以誠、Darawan Rinchai、小川道永、小池正人、内山安男、Ganjana Lertmemongkolchai、阿戸学
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      ビッグパレットふくしま(福島県郡山市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] An immunoelectron microscopy protocol for high resolution endogenous LC3 localization2016

    • Author(s)
      Ann De Maziere、Suzanne van Dijk、Masato Koike、Cilia de Heus、Judith Klumperman
    • Organizer
      Gordon Research Conference Autophagy in Stress, Development & Disease
    • Place of Presentation
      ベンチュラ(アメリカ)
    • Year and Date
      2016-03-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] オメガソームマーカーDFCP1の内在性分子の細胞内局在と組織分布2015

    • Author(s)
      小池正人、七尾友久、山口隼司、内山安男
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 転写因子NF-Yの機能欠損は細胞種特異的な神経変性病態を示す2015

    • Author(s)
      山中智行、戸崎麻子、宮崎晴子、黒澤大、小池正人、内山安男、Sankar N Maity、三澤日出巳、服部信孝、貫名信行
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 変異SOD1発現ALSマウスモデルの運動ニューロン変性はNrf2ではなく、p62/SQSTM1の機能喪失により悪化する2015

    • Author(s)
      三井駿、久保瑞希、潘雷、大友麻子、小池正人、内山安男、青木正志、山本雅之、石井哲郎、柳川徹、Hui-Fang Shang、吉井文均、秦野伸二
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Cellular localization and tissue distribution of endogenous DFCP1 protein2015

    • Author(s)
      Koike, M., Nanao, T., Yamaguchi, J., Sasaki, M., Uchiyama, Y
    • Organizer
      第67回日本細胞生物学会大会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2015-06-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] SEM連続断面観察法を活用した足細胞の立体構造解析2015

    • Author(s)
      市村浩一郎、宮崎直幸、完山正二、村田一義、小池正人、中村桂一郎、太田啓介、坂井建雄
    • Organizer
      日本顕微鏡学会「SEM連続断面観察による生物組織三次元再構築法研究部会」第三回研究会
    • Place of Presentation
      勝沼「ぶどうの丘」
    • Year and Date
      2015-03-25
    • Related Report
      2014 Research-status Report
  • [Presentation] カテプシンD欠損およびAtg7欠損プルキンエ細胞の比較解析による軸索内環境の維持におけるオートファジー・リソソームタンパク質分解系の役割2015

    • Author(s)
      小池正人、内山安男
    • Organizer
      第120回日本解剖学会総会・全国学術集会・第92回日本生理学会大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-03-23
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] カテプシンD欠損マウスの神経細胞内に蓄積する異常なリソソームはp62およびNBR1を介した選択的オートファジーの標的となる2015

    • Author(s)
      山口隼司、七尾友久、小池正人、小松雅明、内山安男
    • Organizer
      第120回日本解剖学会総会・全国学術集会・第92回日本生理学会大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] カテプシンD遺伝子欠損マウス脳におけるToll様受容体の機能解析2015

    • Author(s)
      砂堀毅彦、小池正人、内山安男
    • Organizer
      第120回日本解剖学会総会・全国学術集会・第92回日本生理学会大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] カテプシンD欠損神経細胞において、細胞極性がp62とNBR1を介した選択的オートファジーを制御する2015

    • Author(s)
      七尾友久、山口隼司、小池正人、小松雅明、内山安男
    • Organizer
      第120回日本解剖学会総会・全国学術集会・第92回日本生理学会大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 連続走査電顕断面観察法により解明された足細胞の新しい構造階層2015

    • Author(s)
      市村浩一郎、宮崎直幸、完山正二、村田一義、小池正人、中村桂一郎、太田啓介、坂井建雄
    • Organizer
      第120回日本解剖学会総会・全国学術集会・第92回日本生理学会大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-03-22
    • Related Report
      2014 Research-status Report
  • [Presentation] カテプシンD欠損脳における異常リソソーム蓄積タンパク質の探索2015

    • Author(s)
      曽高友深、内山安男、小池正人
    • Organizer
      第120回日本解剖学会総会・全国学術集会・第92回日本生理学会大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-03-21
    • Related Report
      2014 Research-status Report
  • [Presentation] 順天堂大学大学院医学研究科における形態学的研究の包括的な支援体制について2015

    • Author(s)
      小池正人
    • Organizer
      第39回日本顕微鏡学会関東支部講演会
    • Place of Presentation
      工学院大学
    • Year and Date
      2015-02-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 連続走査電顕断面観察法により解明された足細胞の新しい構造階層2015

    • Author(s)
      市村浩一郎、宮崎直幸、完山正二、村田一義、小池正人、中村桂一郎、太田啓介、坂井建雄
    • Organizer
      第39回日本顕微鏡学会関東支部講演会
    • Place of Presentation
      工学院大学
    • Year and Date
      2015-02-28
    • Related Report
      2014 Research-status Report
  • [Presentation] ゴルジ体局在型イオンチャネルGPHRの中枢神経系における役割2015

    • Author(s)
      曽高友深、小池正人
    • Organizer
      第20回グリアクラブ
    • Place of Presentation
      KKR函館
    • Year and Date
      2015-01-28
    • Related Report
      2014 Research-status Report
  • [Presentation] プルキンエ細胞特異的カテプシンD欠損およびAtg7欠損マウスの比較解析2015

    • Author(s)
      小池正人、砂掘毅彦、内山安男
    • Organizer
      第20回グリアクラブ
    • Place of Presentation
      KKR函館
    • Year and Date
      2015-01-27
    • Related Report
      2014 Research-status Report
  • [Presentation] オリゴデンドロサイト分化におけるmTORC1活性化の意義2015

    • Author(s)
      砂掘毅彦、小池正人
    • Organizer
      第20回グリアクラブ
    • Place of Presentation
      KKR函館
    • Year and Date
      2015-01-27
    • Related Report
      2014 Research-status Report
  • [Presentation] The role of autophagy and lysosomal proteolysis for the maintenance of the normal environment of neuronal cells: a genetic study of mouse models for rare neurodegenerative diseases for understanding of common ones2014

    • Author(s)
      Masato Koike
    • Organizer
      INTERNATIONAL SYMPOSIUM 2014 (CURRENT TRENDS ON NEUROBIOLOGY)
    • Place of Presentation
      Ulsan National Institute of Science and Technology
    • Year and Date
      2014-11-28
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] ラット慢性逆流性食道炎モデルの食道重層上皮における 微細構造の変化についての検討2014

    • Author(s)
      小池正人 、森広樹 、後藤隆洋 、市村浩一郎 、浅岡大介 、永原章仁、上野隆、渡辺純夫、内山安男
    • Organizer
      日本解剖学会第102回関東支部学術集会
    • Place of Presentation
      東京医科大学病院
    • Year and Date
      2014-11-22
    • Related Report
      2014 Research-status Report
  • [Presentation] Selective autophagy of lysosomes with ceroid-lipofuscin in neurons deficient in cathepsin D2014

    • Author(s)
      T. NANAO, M. KOIKE, J. YAMAGUCHI, C. WHITEHOUSE, T. ISHII, M. SHIBATA, Y. UCHIYAMA
    • Organizer
      Society for Neuroscience 2014
    • Place of Presentation
      ワシントンDC
    • Year and Date
      2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] L-carnitine enhances axonal plasticity and improves white matter lesions after chronic hypoperfusion in rat brain2014

    • Author(s)
      Y. UENO, M. KOIKE, Y. SHIMADA, H. SHIMURA, K. HIRA, Y. UCHIYAMA, N. HATTORI, T. URABE
    • Organizer
      Society for Neuroscience 2014
    • Place of Presentation
      ワシントンDC
    • Year and Date
      2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Enrichment of GABARAP relative to LC3 in the axonal initial segments of neurons2014

    • Author(s)
      M. KOIKE, I. TANIDA, T. NANAO, N. TADA, J. IWATA, T. UENO, E. KOMINAMI, Y. UCHIYAMA
    • Organizer
      Society for Neuroscience 2014
    • Place of Presentation
      ワシントンDC
    • Year and Date
      2014-11-18
    • Related Report
      2014 Research-status Report
  • [Presentation] Hippocampal pyramidal neurons lacking LC3A and LC3B are resistant to hypoxic-ischemic brain injury in neonatal mice2014

    • Author(s)
      J. YAMAGUCHI, T. SUNABORI, M. KOIKE, T. NANAO, M. SHIBATA, A. FURUTA, Y. UCHIYAMA
    • Organizer
      Society for Neuroscience 2014
    • Place of Presentation
      ワシントンDC
    • Year and Date
      2014-11-16
    • Related Report
      2014 Research-status Report
  • [Presentation] ”Practical”ですが、何か? -医学部における電子顕微鏡-2014

    • Author(s)
      小池正人
    • Organizer
      日本顕微鏡学会次世代顕微サイエンス若手研究部会 創設記念シンポジウム・若手討論会
    • Place of Presentation
      淡路夢舞台国際会議場
    • Year and Date
      2014-11-04
    • Related Report
      2014 Research-status Report
  • [Presentation] Three-dimensional architecture of podocytes revealed by block-face scanning electron microscopy.2014

    • Author(s)
      Ichimura K, Miyazaki N, Sadayama S, Murata K, Koike M, Nakamura K, Ohta K, Sakai T
    • Organizer
      日本顕微鏡学会次世代顕微サイエンス若手研究部会 創設記念シンポジウム・若手討論会
    • Place of Presentation
      淡路夢舞台国際会議場
    • Year and Date
      2014-11-03 – 2014-11-04
    • Related Report
      2014 Research-status Report
  • [Presentation] ATP13A2やカテプシン異常と神経変性疾患2014

    • Author(s)
      小池正人
    • Organizer
      第55回神経学会学術大会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2014-05-21
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 凍結超薄切片法の利用によるカテプシンD欠損マウス脳の解析2014

    • Author(s)
      小池正人、内山安男
    • Organizer
      日本顕微鏡学会第70回記念学術講演会
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2014-05-13
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] GFP-GABARAPは神経細胞の軸索初節に集積する2014

    • Author(s)
      小池正人
    • Organizer
      第19回グリアクラブ
    • Place of Presentation
      KKR湯沢 ゆきぐに
    • Related Report
      2013 Research-status Report
  • [Presentation] GFP-GABARAPは神経細胞の軸索初節に集積する2014

    • Author(s)
      小池正人、谷田以誠、七尾友久、上野隆、内山安男
    • Organizer
      第119回日本解剖学会総会全国学術集会
    • Place of Presentation
      自治医科大学
    • Related Report
      2013 Research-status Report
  • [Presentation] 神経細胞におけるToll様受容体を介したオートファジー誘導機構の解明2014

    • Author(s)
      砂掘毅彦、小池正人、内山安男
    • Organizer
      第119回日本解剖学会総会全国学術集会
    • Place of Presentation
      自治医科大学
    • Related Report
      2013 Research-status Report
  • [Presentation] ニューロンの極性とp62/Nbr1について2014

    • Author(s)
      七尾友久、小池正人、山口隼司、砂掘毅彦、内山安男
    • Organizer
      第119回日本解剖学会総会全国学術集会
    • Place of Presentation
      自治医科大学
    • Related Report
      2013 Research-status Report
  • [Presentation] 中枢神経系におけるLC3A/Bの役割2014

    • Author(s)
      山口隼司、砂掘毅彦、七尾友久、佐々木光穂、小池正人、内山安男
    • Organizer
      第119回日本解剖学会総会全国学術集会
    • Place of Presentation
      自治医科大学
    • Related Report
      2013 Research-status Report
  • [Presentation] プルキンエ細胞特異的カテプシンD欠損およびAtg7欠損マウスの比較解析2013

    • Author(s)
      小池正人、柴田昌弘、砂堀毅彦、崎村健司、内山安男
    • Organizer
      第36回日本神経科学大会 第56回日本神経化学会大会 第23回日本神経会路学会大会 合同大会
    • Place of Presentation
      京都国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] シナプス前終末におけるAtg9A陽性膜小胞の準精製と特徴づけ2013

    • Author(s)
      山口隼司、七尾友久、佐々木光穂、小池正人、内山安男
    • Organizer
      第36回日本神経科学大会 第56回日本神経化学会大会 第23回日本神経会路学会大会 合同大会
    • Place of Presentation
      京都国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] 不完全にリプログラミングされたヒトiPS細胞は分化誘導に伴うゲノム不安定化を通してグリオーマ様腫瘍を形成する2013

    • Author(s)
      岡田洋平、宮冬樹、小池正人、冨里周太、戸倉智子、石原康晴、下門大祐、服部千夏、兼松大介、金村米博、幸田和久、祖父江元、山中伸弥、柚崎通介、内山安男、池田栄二、角田達彦、岡野栄之
    • Organizer
      第36回日本神経科学大会 第56回日本神経化学会大会 第23回日本神経会路学会大会 合同大会
    • Place of Presentation
      京都国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] グルコセレブロシダーゼを完全に欠損したメダカは脳にアルファシヌクレイン凝集体を形成する2013

    • Author(s)
      上村紀仁、松井秀彰、藤原-石川智子、木下政人、小池正人、山門穂高、植村健吾、内山安男、武田俊一、藤堂剛、高橋良輔
    • Organizer
      第36回日本神経科学大会 第56回日本神経化学会大会 第23回日本神経会路学会大会 合同大会
    • Place of Presentation
      京都国際会議場
    • Related Report
      2013 Research-status Report
  • [Book] Autophagy, Infection, and the Immune Response2014

    • Author(s)
      Tanida I, Koike, M.
    • Total Pages
      352
    • Publisher
      John Wiley & Sons Inc.
    • Related Report
      2014 Research-status Report
  • [Remarks] 順天堂大学大学院医学研究科神経機能構造学

    • URL

      http://www.juntendo.ac.jp/graduate/laboratory/labo/shinkei_kozo/

    • Related Report
      2015 Annual Research Report
  • [Remarks]

    • URL

      http://www.juntendo.ac.jp/graduate/laboratory/labo/shinkei_kozo/

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2023-03-16  

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