Novel mechanisms of bone regeneration induced by the tissue fibrinolytic system through macrophage regulation
| Project/Area Number |
25460305
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Kinki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAJI Hiroshi 近畿大学, 医学部, 教授 (90346255)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 組織線溶系 / マクロファージ / 骨修復・再生 / 骨軟骨再生 / 骨・軟骨再生 |
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| Outline of Final Research Achievements |
We aimed to investigate the role of the tissue fibrinolytic system in macrophage accumulation and their activation during bone repair and regeneration. We found that the tissue fibrinolytic system plays a crucial role in bone repair and regeneration. Moreover, the tissue fibrinolytic system contributes to macrophage accumulation at the damaged site of bone defect and their activation during bone repair. Since these findings suggest that the tissue fibrinolytic system is critical for the formation of a suitable microenvironment for bone repair and regeneration through macrophage accumulation and activation, the spatiotemporal regulation of the tissue fibrinolytic system is a promising strategy to meet the clinical needs for the regeneration of bone tissue for reconstruction. We would like to proceed the further study of the regulation of macrophage functions by the tissue fibrinolytic system for the development of the effective bone repair and regeneration.
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Report
(4 results)
Research Products
(18 results)
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[Presentation] Role of Plasminogen in bone repair2014
Author(s)
Naoyuki Kawao, Hiroshi Kaji, Osamu Matsuo
Organizer
22nd International Congress on Fibrinolysis and Proteolysis
Place of Presentation
World Trade Center (Marseille, France)
Year and Date
2014-07-06 – 2014-07-09
Related Report
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