Analysis of cancer cell clock for chronotherapy
| Project/Area Number |
25460309
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Aichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 時計遺伝子 / 癌 / 低酸素 / 生物時計 / 概日リズム |
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| Outline of Final Research Achievements |
When we consider the strategy of chronotherapy, it is important to know architecture of biological clock oscillation of treatment resistant hypoxic area in cancer tissue. In this project, the effects of hypoxia to cancer clock were examined. Oxygen concentration and timing dependently hypoxic pulse phase shifted cancer clock. Magnitude of phase shift of cancer clock by hypoxic pulse was attenuated by suppression of pH reduction by addition of buffer. Hypoxic pulse increased clock genes, Per1 and Dec1, expressions which were not affected by suppression of pH reduction. From these findings, we can speculate the condition of clock oscillation in hypoxic area of cancer tissue.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Circadian control of fatty acid elongation by SIRT1 protein-mediated deacetylation of acetyl-coenzyme A synthetase 1.2014
Author(s)
Sahar S1, Masubuchi S, Eckel-Mahan K, Vollmer S, Galla L, Ceglia N, Masri S, Barth TK, Grimaldi B, Oluyemi O, Astarita G, Hallows WC, Piomelli D, Imhof A, Baldi P, Denu JM, Sassone-Corsi P.
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Journal Title
J Biol Chem
Volume: 289
Issue: 9
Pages: 6091-6097
DOI
Related Report
Peer Reviewed
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[Presentation] 低酸素は癌細胞時計の位相を変える2014
Author(s)
増渕悟 八木田和弘 中村渉 本間さと 本間 研一
Organizer
第61回中部日本生理学会
Place of Presentation
名古屋市立大学桜山キャンパス
Year and Date
2014-11-07 – 2014-11-08
Related Report
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[Presentation] Cancer clock resetting by hypoxia2014
Author(s)
Satoru Masubuchi, Kazuhiro Yagita, Wataru Nakamura, Sato Honma, Ken-ichi Honma
Organizer
生物リズムに関する札幌シンポジウム30周年記念大会
Place of Presentation
北海道大学学術交流会館（札幌市）
Year and Date
2014-07-25 – 2014-07-27
Related Report
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