| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
We have previously constructed the liposomally formulated phospholipid-conjugated indocyanine green (ICG), designated by LP-iDOPE, as a clinically translatable nanoparticle for tumors. In addition, we have developed the LED device with near-infrared (NIR) light that enable ICG fluorophore of LP-iDOPE to produce singlet oxygen which triggered the induction of CTL to tumor tissues as photo-induced immunotherapy.
Melanoma is one of the most aggressive skin cancers with high multidrug resistance and low survival rate. To evaluate LP-iDOPE as a multifunctional nanoparticle for the promising melanoma therapy, we attached two specific functions on LP-iDOPE, the peptide targeting the transcription factor MITF and the RNA aptamer targeting the biomarker of melanoma stem cell.
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