Pharmacological study on the pain control in cancer chemotherapy in view of depression and diabetes
| Project/Area Number |
25460335
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Research Collaborator |
TSUTSUMI Kuniaki
YAMAMOTO Shota
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 痛み / 末梢神経障害 / がん治療 / 抗うつ薬 / 抗がん薬 / 抗糖尿病薬 / オキサリプラチン / パクリタキセル / 糖尿病 / 炎症反応 / うつ病 / TLR4 / 抗がん剤 / がん化学療法 / GLP-1 |
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| Outline of Final Research Achievements |
In the present study, the promising candidate drugs were explored in view of depression and diabetes as preventive and therapeutic agents on the peripheral neuropathy induced by anti-cancer drugs.
We found that duloxetine and exenatide improved the oxaliplatin-induced peripheral neuropathy. Moreover, we found that polaprezinc reduced the paclitaxel-induced peripheral neuropathy without affecting anti-tumor activity.
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Report
(4 results)
Research Products
(26 results)
