Analysis of novel signaling pathways that regulate mammalian cell cytokinesis
| Project/Area Number |
25460362
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
adachi makoto 京都大学, 医学(系)研究科(研究院), 助教 (30335244)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 細胞質分裂 / 細胞内シグナル伝達 |
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| Outline of Final Research Achievements |
We have found that anillin acts as an effector of IQGAP3 and mediates the function of IQGAP3 to regulate the process of mammalian cell cytokinesis. Anillin was found to directly interact with IQGAP3 and co-localize with IQGAP3 at the cleavage furrow in mitotic cells. It was shown that IQGAP3 is responsible for mammalian cell cytokinesis because of its ability to regulate the localization of anillin at the cleavage furrow. In addition, we have found that IQGAP1, another member of IQGAP family proteins, is also responsible for cytokinesis in mammalian cells, but it did so utilizing a molecular mechanisms distinct from that of IQGAP3. We have established IQGAP1- and IQGAP3-null cultured cells and are analyzing their phenotype in detail. Also, we have found a novel binding partner of IQGAP3 and are analyzing its molecular function.
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Report
(4 results)
Research Products
(4 results)
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[Journal Article] Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos.2013
Author(s)
Hirate Y, Hirahara S, Inoue K-i, Suzuki A, Alarcon VB, Akimoto K, Hirai T, Hara T, Adachi M, Chida K, Ohno S, Marikawa Y, Nakao K, Shimono A, Sasaki H
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Journal Title
Curr. Biol.
Volume: 23
Issue: 13
Pages: 1181-1194
DOI
Related Report
Peer Reviewed / Open Access
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