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Analysis of novel signaling pathways that regulate mammalian cell cytokinesis

Research Project

Project/Area Number 25460362
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General medical chemistry
Research InstitutionKyoto University

Principal Investigator

adachi makoto  京都大学, 医学(系)研究科(研究院), 助教 (30335244)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords細胞質分裂 / 細胞内シグナル伝達
Outline of Final Research Achievements

We have found that anillin acts as an effector of IQGAP3 and mediates the function of IQGAP3 to regulate the process of mammalian cell cytokinesis. Anillin was found to directly interact with IQGAP3 and co-localize with IQGAP3 at the cleavage furrow in mitotic cells. It was shown that IQGAP3 is responsible for mammalian cell cytokinesis because of its ability to regulate the localization of anillin at the cleavage furrow. In addition, we have found that IQGAP1, another member of IQGAP family proteins, is also responsible for cytokinesis in mammalian cells, but it did so utilizing a molecular mechanisms distinct from that of IQGAP3. We have established IQGAP1- and IQGAP3-null cultured cells and are analyzing their phenotype in detail. Also, we have found a novel binding partner of IQGAP3 and are analyzing its molecular function.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2014 2013 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (1 results) Remarks (1 results)

  • [Journal Article] Involvement of IQGAP family proteins in the regulation of mammalian cell cytokinesis2014

    • Author(s)
      Makoto Adachi, Asami Kawasaki, Hisashi Nojima, Eisuke Nishida and Sachiko Tsukita
    • Journal Title

      Genes to Cells

      Volume: 19 Issue: 11 Pages: 803

    • DOI

      10.1111/gtc.12179

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos.2013

    • Author(s)
      Hirate Y, Hirahara S, Inoue K-i, Suzuki A, Alarcon VB, Akimoto K, Hirai T, Hara T, Adachi M, Chida K, Ohno S, Marikawa Y, Nakao K, Shimono A, Sasaki H
    • Journal Title

      Curr. Biol.

      Volume: 23 Issue: 13 Pages: 1181-1194

    • DOI

      10.1016/j.cub.2013.05.014

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 哺乳類細胞における細胞質分裂へのIQGAPファミリー分子の関与2013

    • Author(s)
      足立 誠
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸国際展示場1号館1階
    • Related Report
      2013 Research-status Report
  • [Remarks] 京都大学大学院医学研究科 分子細胞情報学講座ホームページ

    • URL

      http://cell.mfour.med.kyoto-u.ac.jp/

    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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