| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The phagocyte NADPH oxidase, dormant in resting cells, is activated during phagocytosis to produce superoxide, a precursor of microbicidal oxidants. The catalytic core of the phagocyte oxidase is Nox2, a membrane-spaning protein that forms a stable heterodimer with p22phox. In this study, I found that both N- and C-terminal regions play a crucial role in Nox binding to p22phox. Furthermore, I showed that the C-terminal part of Nox1, Nox2 and Nox4 play a role in activation of activator proteins-dependent or -independent activation of Nox family. I also found that the posttranslational modification plays a crucial role for the protein maturation of Nox.
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