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Functional analysis of ATF2 gene family members by using knockout mouse

Research Project

Project/Area Number 25460377
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General medical chemistry
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Maekawa Toshio  国立研究開発法人理化学研究所, 石井分子遺伝学研究室, 研究員 (90201764)

Research Collaborator Liu Binbin  
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords転写因子 / ストレス / ATF7 / テロメア / 自然免疫 / マクロファージ / 長期記憶 / エピジェネティック / ATF-7 / Ku70/Ku80 / p38シグナル伝達経路 / TERT / 次世代への伝達 / p38シグナル経路 / テロメラーゼ / 炎症
Outline of Final Research Achievements

We studied the function of stress-response transcription factor ATF7 by using the ATF7 gene knockout mouse. At first, we found that ATF7 made complex with Ku70/Ku80 and telomerase and regulated telomere length. This function was found not only in mouse cells but also in human cells.
Second, we found that ATF7 suppressed a group of genes encoding factors involved in innate immunity in macrophages. Treatment with lipopolysaccharide increased basal expression of target genes. And these increased expressions were maintained for long periods, which enhanced resistance to pathogens. ATF7 might therefore be important in controlling memory in cells of the innate immune system.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (14 results)

All 2016 2015 2014 Other

All Int'l Joint Research (1 results) Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (9 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Remarks (2 results)

  • [Int'l Joint Research] Universite de Strasbourg(France)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] In utero TNF-α treatment induces telomere shortening in young adult mice in an ATF7-dependent manner2016

    • Author(s)
      B. Liu, T Maekawa, B. Chatton, S. Ishii
    • Journal Title

      FEBS Open Bio

      Volume: 6 Issue: 1 Pages: 56-63

    • DOI

      10.1002/2211-5463.12006

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The transcription factor ATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory.2015

    • Author(s)
      Yoshida K, Maekawa T, Zhu Y, Renard-Guillet C, Ishibashi K,Chatton B, Inoue K, Uchiyama T, Yamada T, Ohno N, Shirahige K, Okada-Hatakeyama M, Ishii S.
    • Journal Title

      Nat Immunol.

      Volume: 16(10) Issue: 10 Pages: 1034-43

    • DOI

      10.1038/ni.3257

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] The transcription factor ATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory2016

    • Author(s)
      K. Yoshida, T. Maekawa, Y. Zhu, C. Renard-Guillet, B. Chatton, K. Inoue, T Uchiyama, K. Ishibashi, T. Yamada, N. Ohno, K. Shirahige, M. Okada-Hatakeyama, S. Ishii
    • Organizer
      RIKEN Epigenetics International Symposium
    • Place of Presentation
      理研・鈴木梅太郎ホール、和光市、埼玉県
    • Year and Date
      2016-02-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ATF7 mediates stress-induced telomere shortening2016

    • Author(s)
      T. Maekawa, L. Binbin, K. Yoshida, S. Ishii
    • Organizer
      RIKEN Epigenetics International Symposium
    • Place of Presentation
      理研・鈴木梅太郎ホール、和光市、埼玉県
    • Year and Date
      2016-02-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] TNF-alpha treatment in fathers programs telomere shortening in mouse offspring2015

    • Author(s)
      Binbin Liu, Toshio Maekawa Shunsuke Ishii
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド、神戸市、兵庫県
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 転写因子ATF7を介したストレスによるテロメアの長さの制御2015

    • Author(s)
      前川利男、Binbin Liu、吉田圭介、仲村賢一、田久保海誉、増富健吉、小池学、石川冬木、石井俊輔
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド、神戸市、兵庫県
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] ATF7はエピジェネティック記憶を通じて、自然免疫記憶を制御する2015

    • Author(s)
      吉田圭介、前川利男、Yujuan Zhu、Claire R. Guillet、Bruno Chatton、井上健太郎、内山健、石橋健一、山田拓司、大野尚仁、白鬚克彦、岡田眞里子、石井俊輔
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド、神戸市、兵庫県
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 転写因子ATF-7を介したストレスによるテロメアの長さの制御2014

    • Author(s)
      前川 利男、Binbin Liu、吉田 圭介、仲村 賢一、田久保 海誉、石井 俊輔
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜市 パシフィコ横浜
    • Year and Date
      2014-11-26
    • Related Report
      2014 Research-status Report
  • [Presentation] ストレスによるエピゲノム変化の遺伝

    • Author(s)
      前川利男、石井俊輔
    • Organizer
      日本エピジェネティクス研究会
    • Place of Presentation
      奈良市、新公会堂
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 転写因子ATF-7を介したストレスによる老化と次世代への遺伝

    • Author(s)
      前川利男
    • Organizer
      理研シンポジウム
    • Place of Presentation
      茨城県つくば市、理研BRC
    • Related Report
      2013 Research-status Report
  • [Presentation] 転写因子ATF-7を介したストレスによるテロメアの長さの制御

    • Author(s)
      前川 利男、Binbin Liu、吉田 圭介、仲村 賢一、田久保 海誉、石井 俊輔
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸市、神戸ポートアイランド
    • Related Report
      2013 Research-status Report
  • [Remarks] 理化学研究所・石井分子遺伝学研究室・ ホームページ

    • URL

      http://rtcweb.rtc.riken.jp/lab/mg/mg.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 理化学研究所 研究紹介 石井分子遺伝学研究室

    • URL

      http://www.riken.go.jp/research/labs/distinguished/mol_genet/

    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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