Functional analysis of ATF2 gene family members by using knockout mouse
| Project/Area Number |
25460377
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Maekawa Toshio 国立研究開発法人理化学研究所, 石井分子遺伝学研究室, 研究員 (90201764)
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| Research Collaborator |
Liu Binbin
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 転写因子 / ストレス / ATF7 / テロメア / 自然免疫 / マクロファージ / 長期記憶 / エピジェネティック / ATF-7 / Ku70/Ku80 / p38シグナル伝達経路 / TERT / 次世代への伝達 / p38シグナル経路 / テロメラーゼ / 炎症 |
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| Outline of Final Research Achievements |
We studied the function of stress-response transcription factor ATF7 by using the ATF7 gene knockout mouse. At first, we found that ATF7 made complex with Ku70/Ku80 and telomerase and regulated telomere length. This function was found not only in mouse cells but also in human cells.
Second, we found that ATF7 suppressed a group of genes encoding factors involved in innate immunity in macrophages. Treatment with lipopolysaccharide increased basal expression of target genes. And these increased expressions were maintained for long periods, which enhanced resistance to pathogens. ATF7 might therefore be important in controlling memory in cells of the innate immune system.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] The transcription factor ATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory2015
Author(s)
Yoshida K, Maekawa T, Zhu Y, Renard-Guillet C, Ishibashi K,Chatton B, Inoue K, Uchiyama T, Yamada T, Ohno N, Shirahige K, Okada-Hatakeyama M, Ishii S.
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Journal Title
Nat. Immunol.
Volume: 16(10)
Pages: 1034-1043
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] The transcription factor ATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory2016
Author(s)
K. Yoshida, T. Maekawa, Y. Zhu, C. Renard-Guillet, B. Chatton, K. Inoue, T Uchiyama, K. Ishibashi, T. Yamada, N. Ohno, K. Shirahige, M. Okada-Hatakeyama, S. Ishii
Organizer
RIKEN Epigenetics International Symposium
Place of Presentation
理研・鈴木梅太郎ホール、和光市、埼玉県
Year and Date
2016-02-15
Related Report
Int'l Joint Research
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