Elucidation of signals and metabolic bases that regulate functions of plasma membrane microdomains
Project/Area Number |
25460385
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pathological medical chemistry
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Research Institution | The University of Tokyo (2016) Nagoya University (2013-2015) |
Principal Investigator |
Yamauchi Yoshio 東京大学, 大学院農学生命科学研究科(農学部), 特任准教授 (00444878)
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Co-Investigator(Kenkyū-buntansha) |
古川 鋼一 中部大学, 生命健康科学部, 教授 (80211530)
|
Co-Investigator(Renkei-kenkyūsha) |
UESUGI Motonari 京都大学, 物質-細胞統合システム拠点, 教授 (10402926)
|
Research Collaborator |
CHANG Ta-Yuan Chang Geisel School of Medicine at Dartmouth, 教授
|
Project Period (FY) |
2013-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 膜ドメイン / 脂質代謝 / シグナル / がん / シグナル伝達 / コレステロール / スフィンゴ糖脂質 / 代謝 / mTOR / 癌 |
Outline of Final Research Achievements |
Plasma membrane microdomains (lipid rafts) play essential roles in cellular functions and in malignant properties of cancer cells. It is therefore important for developing therapeutic strategies for malignant tumor, to understand how functionality of lipid rafts is preserved in cancer cells. In this study, we showed that SREBP, a transcriptional factor that regulates lipid metabolism, functions as a crucial factor maintaining integrity of lipid rafts in and malignant properties of cancer cells. Furthermore, we revealed regulatory mechanisms that control the activation of SREBP at the endoplasmic reticulum.
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Report
(5 results)
Research Products
(34 results)
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[Journal Article] Raft-based interactions of gangliosides with a GPI-anchored receptor2016
Author(s)
N. Komura, K. G. N. Suzuki, H. Ando, M. Konishi, M. Koikeda, A. Imamura, R. Chadda, T. K. Fujiwara, H. Tsuboi, R. Sheng, W. Cho, K. Furukawa, K. Furukawa, Y. Yamauchi, H. Ishida, A. Kusumi (Co-Corresponding Author), and M. Kiso
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Journal Title
Nat. Chem. Biol.
Volume: in press
Issue: 6
Pages: 402-410
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Expression analysis of 0-series gangliosides in human cancer cell lines with monoclonal antibodies generated using knockout mice of ganglioside synthase genes2016
Author(s)
Bhuiyan RH, Kondo Y, Yamaguchi T, Tokuda N, Ohkawa Y, Hashimoto N, Ohmi Y, Yamauchi Y, Furukawa K, Okajima T, Furukawa K
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Journal Title
Glycobiology
Volume: 26
Issue: 9
Pages: 984-998
DOI
Related Report
Peer Reviewed
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[Journal Article] Increased expression levels of ppGalNAc-T13 in lung cancers: Significance in the prognostic diagnosis2016
Author(s)
Nogimori K, Hori T, Kawaguchi K, Fukui T, Mii S, Nakada H, Matsumoto Y, Yamauchi Y, Takahashi M, Furukawa K, Tetsuya O, Yokoi K, Hasegawa Y, Furukawa K
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Journal Title
Int J Oncol
Volume: 49
Issue: 4
Pages: 1369-1376
DOI
Related Report
Peer Reviewed
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[Journal Article] Raft-based interactions of gangliosides with a GPI-anchored receptor2016
Author(s)
Komura N, Suzuki KG, Ando H, Konishi M, Koikeda M, Imamura A, Chadda R, Fujiwara TK, Tsuboi H, Sheng R, Cho W, Furukawa K, Furukawa K, Yamauchi Y, Ishida H, Kusumi A, Kiso M.
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Journal Title
Nature Chem Biol
Volume: 印刷中
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Deficiency in the Lipid Exporter ABCA1 Impairs Retrograde Sterol Movement and Disrupts Sterol Sensing at the Endoplasmic Reticulum2015
Author(s)
Yamauchi Y, Iwamoto N, Rogers MA, Abe-Dohmae S, Fujimoto T, Chang CC, Ishigami M, Kishimoto T, Kobayashi T, Ueda K, Furukawa K, Chang TY, Yokoyama S.
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Journal Title
J Biol Chem
Volume: 290
Issue: 39
Pages: 23464-23477
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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