Study of a novel NF-kappaB-regulating protein, Nucling, in the development of non-alcoholic fatty liver diseases
| Project/Area Number |
25460388
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Tokushima Bunri University (2014-2015)
The University of Tokushima (2013) |
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Principal Investigator |
SAKAI TAKASHI 徳島文理大学, その他の研究科, 教授 (80284321)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUI Kiyoshi 徳島大学, 疾患酵素学研究センター, 教授 (00175564)
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| Research Collaborator |
Dang Huy Van
Pham Tuan Anh
Tran Diem Hong
Kim Sun Mi
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | NAFLD / Nucling / NF-κB / metabolic syndrome / insulin resistance / 炎症性疾患 / アポトーシス / NFκB / ヌクリング / 離乳後乳腺退縮現象 / STAT3 / メタボリック症候群 |
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| Outline of Final Research Achievements |
Nonalcoholic fatty liver disease, NAFLD, is a cause of a fatty liver not due to excess alcohol use, which is related to insulin resistance and metabolic abnormalities. Here, we found that Nucling-KO mice develop hallmark features of NAFLD. We hypothesized that these metabolic changes might correlate with the accumulation of oxidative stress in liver, and malfunction of insulin regulation in pancreas. Nucling deficiency promoted the accumulation of reactive oxygen species in liver of mice. High fat diet revealed dysregulation of insulin expression in the Nucling-KO mice. We also found that glucose-induced insulin up-regulation requires NF-κB activation, which is dysregulated in Nucling-KO mice. These results suggest that defect of the Nucling-NF-κB system promoted the malfunction of insulin transcription resulted in development of metabolic disorders including NAFLD. In conclusion, we propose that NF-κB signal is important for the homeostatic regulation of insulin transcription.
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Report
(4 results)
Research Products
(27 results)
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[Presentation] Medical Aspects of D-Amino Acid Metabolism: Molecular Target for Cancer Gene Therapy and Schizophrenia
Author(s)
Kiyoshi Fukui, Yoshiteru Urai, Hwan Ki Park, Tomoya Kawazoe, Sanae Iwana, Koji Ono, Rabab M. Abou El-Magd, Seong Pil Chung, Salah M. El Sayed, Diem Hong Tran, Yuji Shishido, Kazuko Yorita, Takashi Sakai
Organizer
FAOBMB Mini-Symposium-Molecular Bases for Medical and Pharmaceutical Sciences-
Place of Presentation
岩手医科大学（岩手県）
Related Report
Invited
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