| Project/Area Number |
25460429
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Toho University (2015-2016)
Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology (2013-2014) |
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Principal Investigator |
HONMA Naoko 東邦大学, 医学部, 准教授 (70321875)
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| Co-Investigator(Renkei-kenkyūsha) |
ARAI Tomio 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (20232019)
YAMAMOTO Noriko 公益財団法人がん研究会, がん研究所 病理部, 主任研究員 (10280629)
ISHIKAWA Yuichi 公益財団法人がん研究会, がん研究所 病理部, 部長 (80222975)
MURAMATSU Masaaki 東京医科歯科大学, 難治疾患研究所, 教授 (50230008)
HARADA Nobuhiro 藤田保健衛生大学, 医学部, 教授 (00189705)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 大腸癌 / エストロゲン / 女性 / 年齢 / 閉経後 / 性 / エストロゲン受容体β / 高齢者 / estrogen receptor-beta / マイクロサテライト不安定性 |
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| Outline of Final Research Achievements |
Characteristics of colorectal cancer (CRC) are affected by aging, sex, and locus, Estrogens have been suggested to play a suppressive role in CRC, though controversies exist. We focused on postmenopausal colon cancers, and comprehensively examined estrogen-related factors using surgically resected materials, The relation of estrogen concentration or estrogen receptor-beta expression in cancerous tissue vs. non-cancerous tissue was distinctly different according to patients' age (>= 70y/o or < 70 y/o) and locus (left-sided or right-sided), suggesting that pathobiological role of estrogens in colon cancer is different according to patients' age and tumor locus.
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