| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
By the end of this research period 5021 cases have been registered in the Chernobyl tissue bank. Using spontaneous adult papillary thyroid carcinomas from Japan and the Chernobyl area, the histopathological examination was performed. As a result both pediatric and adult papillary carcinomas in the Chernobyl area showed higher percentages of solid component, suggesting that the low-dietary iodine environment and genetic background bring differences in morphogenesis and radiation sensitivity.
And juvenile thyroid cancer cases of Fukushima showed commonly classic type papillary carcinoma and BRAF point mutation. These results are different from Chernobyl cases, which show high frequencies of solid component and ret/PTC rearrangement.
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