Mechanisms of radiation-induced thyroid cancer

• Project/Area Number: 25460470
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Department of Clinical Research, National Hospital Organization Nagasaki Medical Center
• Principal Investigator: Ito Masahiro 独立行政法人国立病院機構(長崎医療センター臨床研究センター), 機能形態研究部, 教授 (30184691)
• Co-Investigator(Kenkyū-buntansha): NAKASHIMA Masahiro 長崎大学, 医歯薬学総合研究科(医学系), 教授 (50284683)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: チェルノブイリ / 放射線被曝 / 小児甲状腺癌 / 低ヨード / 福島原発事故 / 小児甲状腺がん / 遺伝子不安定 / 放射線影響 / 発がん / 福島第一原発事故 / 分子疫学 / 病理 / 甲状腺癌 / 放射線

Outline of Final Research Achievements

By the end of this research period 5021 cases have been registered in the Chernobyl tissue bank. Using spontaneous adult papillary thyroid carcinomas from Japan and the Chernobyl area, the histopathological examination was performed. As a result both pediatric and adult papillary carcinomas in the Chernobyl area showed higher percentages of solid component, suggesting that the low-dietary iodine environment and genetic background bring differences in morphogenesis and radiation sensitivity.
And juvenile thyroid cancer cases of Fukushima showed commonly classic type papillary carcinoma and BRAF point mutation. These results are different from Chernobyl cases, which show high frequencies of solid component and ret/PTC rearrangement.

Research Products

• [Int'l Joint Research] Institute of Endocrinology(Ukraine)
• [Int'l Joint Research] Cancer Institute(Belarus)
• [Int'l Joint Research]
• [Journal Article] Association between p53-binding protein 1 expression and genomic instability in oncocytic follicular adenoma of the thyroid. (2016)
  • Author(s): Mussazhanova Z, Akazawa Y, Matsuda K, Shichijo K, Miura S, Otsubo R, Oikawa M, Yoshiura KI, Mitsutake N, Rogounovitch T, Saenko V, Kozykenova Z, Zhetpisbaev B, Shabdarbaeva D, Sayakenov N, Amantayev B, Kondo H, Ito M, Nakashima M.
  • Journal Title: Endocr J. Volume: x
  • NAID: 130005154197
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] BRAFV600E mutation is highly prevalent in thyroid carcinomas in the young population in Fukushima: a different oncogenic profile from Chernobyl. (2015)
  • Author(s): Mitsutake N, Fukushima T, Matsuse M, Rogounovitch T, Saenko V, Uchino S, Ito M, Suzuki K, Suzuki S, Yamashita S
  • Journal Title: Sci Rep Volume: 5 Issue: 1 Pages: 16976-16976
  • DOI: 10.1038/srep16976
  • NAID: 120006986823
  • Peer Reviewed / Open Access
• [Journal Article] The common genetic variant rs944289 on chromosome 14q13.3 associates with risk of both malignant and benign thyroid tumors in the Japanese population. (2015)
  • Author(s): Rogounovitch TI, Bychkov A, Takahashi M, Mitsutake N, Nakashima M, Nikitski AV, Hayashi T, Hirokawa M, Ishigaki K, Shigematsu K, Bogdanova T, Matsuse M, Nishihara E, Minami S, Yamanouchi K, Ito M, Kawaguchi T, Kondo H, Takamura N, Ito Y, Miyauchi A, Matsuda F, Yamashita S, Saenko VA.
  • Journal Title: Thyroid Volume: 25 Issue: 3 Pages: 333-340
  • DOI: 10.1089/thy.2014.0431
  • NAID: 120006987147
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Morphological difference in adult thyroid papillary carcinoma between Japan and Ukraine (2014)
  • Author(s): Ito M, Bogdanova T, Zurnadzhy L, Saenko V, Rogounovitch T, Mitsutake N, Kondo H, Maeda S, Nakashima M, Tronko M, Yamashita S.
  • Journal Title: Endocrine Journal Volume: 61 Issue: 12 Pages: 1221-1228
  • DOI: 10.1507/endocrj.EJ14-0239
  • NAID: 130004690931
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access
• [Journal Article] Radiation-associated small cell neuroendocrine carcinoma of the thyroid: a case report with molecular analyses. (2014)
  • Author(s): Mussazhanova Z, Miura S, Stanojevic B, Rogounovitch T, Shiraishi T, Kurashige T, Shichijo K, Kaneko K, Takahashi H, Ito M, Nakashima M
  • Journal Title: Thyroid Volume: 24 Issue: 3 Pages: 593-598
  • DOI: 10.1089/thy.2013.0214
  • NAID: 120006986646
  • Peer Reviewed
• [Journal Article] Thyrotropin signaling confers more aggressive features with higher genomic instability on BRAFV600E-induced thyroid tumors in a mouse model. (2014)
  • Author(s): Orim F, Bychkov A, Shimamura M, Nakashima M, Ito M, Matsuse M, Kurashige T, Suzuki K, Saenko V, Nagayama Y, Yamashita S, Mitsutake N
  • Journal Title: Thyroid Volume: 24(3) Issue: 3 Pages: 502-510
  • DOI: 10.1089/thy.2013.0038
  • NAID: 120006986647
  • Peer Reviewed
• [Journal Article] Significance of p53-binding protein 1 (53BP1) expression in thyroid papillary microcarcinoma: association with BRAFV600E mutation status. (2013)
  • Author(s): Mussazhanova Z, Matsuda K, Naruke Y, Mitsutake N, Stanojevic B, Rogounovitch T, Saenko V, Suzuki K, Nishihara E, Hirokawa M, Ito M, Nakashima M.
  • Journal Title: HIstopathology Volume: 63 Issue: 5 Pages: 726-734
  • DOI: 10.1111/his.12233
  • Peer Reviewed
• [Journal Article] Long-term trend of thyroid cancer risk among Japanese atomic-bomb survivors: Sixty years after exposure. (2013)
  • Author(s): Furukawa K
  • Journal Title: Int J Cancer Volume: 132 Issue: 5 Pages: 1222-1226
  • DOI: 10.1002/ijc.27749
  • Peer Reviewed
• [Journal Article] 放射線と甲状腺癌 (2013)
  • Author(s): 伊東正博、Tatiana Bogdanova, 中島正洋、山下俊一
  • Journal Title: 病理と臨床 Volume: 31 Pages: 1-12
• [Presentation] Chernobyl thyroid tissue bank (2015)
  • Author(s): Ito M, Yamashita S
  • Organizer: The 1st International Workshop on Sample/Tissue Archiving of Radiobiology
  • Place of Presentation: Shirankaikan, Kyoto University School of Medicine
  • Year and Date: 2015-05-24
  • Int'l Joint Research / Invited
• [Presentation] チェルノブイリ組織バンクの活動状況と課題 (2015)
  • Author(s): 伊東正博,Tatiana Bogdanova, Alexander Abrosimov, Guido Fadda, Jeniffer Hunt, Gerry Thomas, 中島正洋、山下俊一
  • Organizer: 第104回日本病理学会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-04-30
• [Presentation] ヨード環境の異なる地域の甲状腺乳頭癌のMIB1 Index (2014)
  • Author(s): 伊東正博、タチアナ・ボグダノワ、黒濱大和、三原裕美、前田茂人、中島正洋、山下俊一
  • Organizer: 第2回甲状腺病理学会
  • Place of Presentation: 神戸市
  • Year and Date: 2014-07-12
• [Presentation] 本邦とウクライナの成人甲状腺乳頭癌の組織学的比較 (2014)
  • Author(s): 伊東正博、Tatiana Bogdanova,前田茂人、近藤久義、中島正洋、山下俊一
  • Organizer: 第103回日本病理学会
  • Place of Presentation: 広島
  • Year and Date: 2014-04-24 – 2014-04-26
• [Presentation] 本邦とチェルノブイリ周辺の甲状腺乳頭癌の病理組織像の比較 [シンポジウム2 福島原発事故と甲状腺癌」 (2013)
  • Author(s): 伊東正博, Tatiana Bogdanova, 中島正洋, 山下俊一
  • Organizer: 第101回日本甲状腺学会
  • Place of Presentation: 山梨
  • Invited
• [Presentation] ウクライナ成人症例と本邦症例の臨床病理学的検討 (2013)
  • Author(s): 伊東正博、Bogdanova T, 黒濱大和、三原裕美、梅崎靖、前田茂人、中島正洋、山下俊一
  • Organizer: 第102回日本病理学会
  • Place of Presentation: 札幌
• [Presentation] 甲状腺癌の病理細胞診と小児甲状腺癌の病理 (2013)
  • Author(s): 伊東 正博
  • Organizer: 甲状腺超音波検査講習会
  • Place of Presentation: 福島
  • Invited
• [Presentation] 甲状腺の病理組織と細胞診像、放射線と甲状腺癌 (2013)
  • Author(s): 伊東 正博
  • Organizer: 甲状腺超音波検査講習会
  • Place of Presentation: 郡山
  • Invited
• [Book] Thyroid cancer pathology in Ukraine after Chernobyl (2014)
  • Author(s): Bogdanova T, Zurnadzhy L, LiVolsi VA, Williams ED, Ito M, Nakashima M, Thomas GA
  • Total Pages: 276
  • Publisher: IN-TEX Ltd