Investigation of a comprehensive picture of toxocariasis.

• Project/Area Number: 25460518
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Parasitology (including sanitary zoology)
• Research Institution: Nara Medical University
• Principal Investigator: NAKAMURA-UCHIYAMA Fukumi 奈良県立医科大学, 医学部, 准教授 (90295204)
• Co-Investigator(Kenkyū-buntansha): AKAO Nobuaki 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (00126559)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: トキソカラ症 / 内蔵型トキソカラ症 / 眼型トキソカラ症 / 免疫診断 / LES抗原 / 迅速診断キット / 好酸球増多 / アルベンダゾール / トキソカラ症免疫診断

Outline of Final Research Achievements

The aim of this study was investigation of a comprehensive picture of toxocariasis. Only one case enrolled in the study affected prohibition of raw beef distribution. We diagnosed chronic eosinophilic pneumonia mimicking toxocariasis. A patient having peripheral eosinophilia with multiple lung nodules should consider not only toxocariasis but also eosinophilic pneumonia.
We developed new rapid diagnostic kit named ToxocaraICA instead of ToxocaraCHECK. ToxocaraICA had similar sensitivity of ToxocataCHECK.

Research Products

• [Journal Article] 温熱療法が有効であった播種性皮膚Mycobacterium chelonae感染症の1例 (2015)
  • Author(s): 吉本昭、中村（内山）ふくみ ほか
  • Journal Title: 感染症学雑誌 Volume: 89 Pages: 410-415
  • Peer Reviewed
• [Journal Article] Pseudo-SLE by human immunodeficiency virus infection. (2015)
  • Author(s): Ochi S, Kato S, et al
  • Journal Title: Mod Rheumatol Volume: 24 Pages: 1-3
  • Peer Reviewed
• [Journal Article] Molecular identification of Anisakis and Hysterothylacium larvae in marine fishes from the East China Sea and the Pacific coast of central Japan (2015)
  • Author(s): Kong, Q. Fan, L. Zhang, J. Akao, N. Dong, K. Lou, D. Ding, J. Tong, Q. Zheng, B. Chen, R. Ohta, N. Lu, S.
  • Journal Title: Int J Food Microbiol Volume: 199 Pages: 1-7
  • DOI: 10.1016/j.ijfoodmicro.2015.01.007
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Loiasis in a Japanese Traveler Returning from Central Africa (2015)
  • Author(s): Kobayashi T, Hayakawa K, Mawatari M, Itoh M, Akao N, Yotsu RR, Sugihara J, Takeshita N, Kutsuna S, Fujiya Y, Kanagawa S, Ohmagari N, Kato Y.
  • Journal Title: Tropical Medicine and Health Volume: 43 Issue: 2 Pages: 149-153
  • DOI: 10.2149/tmh.2015-05
  • NAID: 130005085461
  • ISSN: 1348-8945, 1349-4147
  • Peer Reviewed
• [Journal Article] 国内におけるトキソカラ症の実態 (2015)
  • Author(s): 中村（内山）ふくみ
  • Journal Title: モダンメディア Volume: 61
• [Book] モダンメディア 国内におけるトキソカラ症の実態 (2015)
  • Author(s): 中村（内山）ふくみ
  • Total Pages: 9
  • Publisher: 栄研化学
• [Book] 臨床検査 蠕虫による感染症（幼虫移行症を含む）の検査・診断 (2015)
  • Author(s): 中村（内山）ふくみ
  • Total Pages: 7
  • Publisher: 医学書院
• [Book] 別冊日本臨牀 新領域別症候群シリーズ No. 32 骨格筋症候群（第２版）「イヌ・ネコ回虫（トキソカラ）症」 (2015)
  • Author(s): 赤尾信明、 吉川正英
  • Total Pages: 4
  • Publisher: 日本臨牀
• [Book] Qシリーズ 新微生物学「寄生虫症」 (2015)
  • Author(s): 赤尾信明
  • Total Pages: 25
  • Publisher: 日本医事新報社
• [Book] 感染症専門医テキスト（第２版）「寄生虫感染症の検査」「原虫症感染症の検査」 (2015)
  • Author(s): 赤尾信明
  • Total Pages: 15
  • Publisher: 南江堂（日本感染症学会）
• [Book] 南山堂医学大辞典「肝蛭、Toxocara属、広東住血線虫、コスタリカ住血線虫、旋尾線虫、東洋眼虫、浮遊法」 (2015)
  • Author(s): 赤尾信明
  • Total Pages: 7
  • Publisher: 南山堂