| Project/Area Number |
25460673
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Gunma University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Murakami Hirokazu 群馬大学, 保健学研究科, 教授 (40166260)
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| Research Collaborator |
Minato Yusuke
Kasamatsu Tetsuhiro
Gotoh Nanami
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 多発性骨髄腫 / 塩基除去修復遺伝子 / OGG1 / PARP-1 / 多型 / 塩基除去修復 / PARP / DNA修復 / 遺伝子多型 / APE1 / PARP1 |
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| Outline of Final Research Achievements |
Polymorphism studies of base excision repair (BER) genes, including OGG1, XRCC1, APE1, MUTYH,and PARPI, showed that multiple myeloma （MM) patients with OGG1 Cys/Cys (low activity type) or PARP-1 non Val/Val (low activity type) were increased than health controls. Furthermore, mRNA expression of BER genes, incuding OGG1, APE1, and PARP-1 ,was increased in MM patiets. In additon, new generation PARP-1 inhibitor was effective in MM cell lines, suggesting inhibition of BER pathway may be a treatment opition in the future.
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