| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Outline of Final Research Achievements |
There have been a host of reports on pre-analytical variables in clinical laboratory(lab) tests. However,the test results had not been standardized,and the protocols were not comprehensible with inclusion of limited number of experimental conditions and test items. In this study,we planned to build a standardized data repository of experimental results on pre-analytical variables of common lab tests.
As an initial attempt,we have conducted five experiments. Effects of storage temperature (-30,-20,-10, 0, 4, 10, 25, 37°C) were examined. Most unstable was -10°C for many tests. Diurnal rhythm was observed prominently in iron and P. Effects of 30-min interval postural changes(PC) were analyzed by every 5-min sampling. For lab tests sensitive to PS, 20 mins was required for stabilization after PC. Menstrual cycle related changes were observed in HDL-C, Na,and TC. Additional experiments are planned to build a data repository truly useful for the practice of evidence-based lab medicine.
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