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The roles of STAT5B for gene regulation on human CD4+ T cells

Research Project

Project/Area Number 25460697
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Laboratory medicine
Research InstitutionJichi Medical University

Principal Investigator

Kanai Takahiro  自治医科大学, 医学部, 講師 (00398504)

Co-Investigator(Kenkyū-buntansha) Odaka Jun  自治医科大学, 医学部, 講師 (70382885)
Aoyagi Jun  自治医科大学, 医学部, 助教 (80438639)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords小児特発性ステロイド感受性ネフローゼ症候群 / T細胞 / 遺伝子工学 / STAT5B / CD4+T細胞 / CD4+ T 細胞 / 川崎病
Outline of Final Research Achievements

We revealed several genes that were regulated by STAT5B on human T cells. Some of the genes were corresponding to the phenotype of idiopathic steroid-sensitive nephrotic syndrome in children. When we analyzed the serum from the patients with idiopathic steroid-sensitive nephrotic syndrome, a substance was found which serum levels were associated with urinary protein/urinary creatinine levels. This is the first time to report the association of the substance and the status of idiopathic steroid-sensitive nephrotic syndrome. In next step, we are planning to find how the substance effects on the pathophysiology of idiopathic steroid-sensitive nephrotic syndrome.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (1 results)

All 2015

All Presentation (1 results)

  • [Presentation] 特発性ステロイド感受性ネフローゼ症候群におけるApolipoprotein AIIとUP/UCrとの関連2015

    • Author(s)
      別井広幸
    • Organizer
      日本小児科学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-17
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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