The roles of STAT5B for gene regulation on human CD4+ T cells
Project/Area Number |
25460697
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Laboratory medicine
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Research Institution | Jichi Medical University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
Odaka Jun 自治医科大学, 医学部, 講師 (70382885)
Aoyagi Jun 自治医科大学, 医学部, 助教 (80438639)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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Keywords | 小児特発性ステロイド感受性ネフローゼ症候群 / T細胞 / 遺伝子工学 / STAT5B / CD4+T細胞 / CD4+ T 細胞 / 川崎病 |
Outline of Final Research Achievements |
We revealed several genes that were regulated by STAT5B on human T cells. Some of the genes were corresponding to the phenotype of idiopathic steroid-sensitive nephrotic syndrome in children. When we analyzed the serum from the patients with idiopathic steroid-sensitive nephrotic syndrome, a substance was found which serum levels were associated with urinary protein/urinary creatinine levels. This is the first time to report the association of the substance and the status of idiopathic steroid-sensitive nephrotic syndrome. In next step, we are planning to find how the substance effects on the pathophysiology of idiopathic steroid-sensitive nephrotic syndrome.
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Report
(4 results)
Research Products
(1 results)