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Differential response to a selective COX-2 inhibitor between human lumbar and cervical intervertebral disc cells on innervation and disc degeneration.

Research Project

Project/Area Number 25460728
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pain science
Research InstitutionTokyo Medical University

Principal Investigator

TANAKA HIDETOSHI  東京医科大学, 医学部, 助教 (90317876)

Co-Investigator(Kenkyū-buntansha) 澤地 恭昇  東京医科大学, 医学部, 助教(特任) (20571152)
遠藤 健司  東京医科大学, 医学部, 講師 (90266479)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords頚部痛 / 椎間板性腰痛 / 神経成長因子 / 細胞外基質分解酵素 / 選択的COX-2阻害剤 / プロスタグランジン / 頚椎症 / 椎間板 / 神経侵入 / ステロイド / NSAIDs / 頸椎症
Outline of Final Research Achievements

The molecular mechanism of developing low back pain is known as disc degeneration by MMP and following nerve innervation by NGF, however that of neck pain was unknown. The effect of selective COX-2 inhibitors, which is clinically used for both low back pain and neck pain, on NGF and MMP expressions were investigated and compared the effect between human lumbar and cervical intervertebral disc (IVD) cells. IL-1-induced NGF and MMP expression were enhanced by selective COX-2 inhibitors in both lumbar and cervical IVD cells, on the other hand, these expressions were suppressed by PGE2 and other prostanoids via EP4 receptor. Our findings would be of importance when choosing drugs for the treatment of low back pain and neck pain.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (7 results)

All 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (6 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] PGE1 attenuates IL-1b-induced NGF expression in human intervertebral disc cells2016

    • Author(s)
      Kazuma Murata, Yasunobu Sawaji, Wuqikun Alimasi, Hidekazu Suzuki, Kenji Endo, Hidetoshi Tanaka, Makiko Yorifuji, Taiichi Kosaka, Takaaki Shishido, Kengo Yamamoto
    • Journal Title

      Spine

      Volume: 41 Issue: 12 Pages: E710-E716

    • DOI

      10.1097/brs.0000000000001379

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] PGE1によるMMP-1/-13とTIMP-3発現の相反的調節による椎間板変性保護効果2016

    • Author(s)
      澤地恭昇,村田寿馬,鈴木秀和,遠藤健司,田中英俊,山本謙吾
    • Organizer
      第31回 日本整形外科学会基礎学術集会
    • Place of Presentation
      福岡国際会議場 福岡県
    • Year and Date
      2016-10-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] Protective role of prostaglandin E1 for disc degeneration by reciprocally regulating collagenases and their endogenous inhibitor TIMP-3 in human intervertebral disc cells2016

    • Author(s)
      Sawaji Y., Suzuki H., Endo K., Tanaka H., Nishimura H., Kosaka T., Yamamoto K.
    • Organizer
      The International Society for the Study of Lumbar Spine
    • Place of Presentation
      Singapore
    • Year and Date
      2016-05-16
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] プロスタグランジンによる椎間板変性制御機構の検討 ~ヒト椎間板細胞におけるMMP-1/-13発現に着目して~2016

    • Author(s)
      澤地恭昇,村田寿馬,鈴木秀和,遠藤健司,依藤麻紀子,田中英俊,小坂泰一,山本謙吾
    • Organizer
      第45回 日本脊椎脊髄病学会学術集会
    • Place of Presentation
      幕張メッセ 国際会議場 (千葉市)
    • Year and Date
      2016-04-14
    • Related Report
      2015 Research-status Report
  • [Presentation] PGE2 negatively regulates NGF expression by inducing DUSP-1 in human intervertebral disc cells2015

    • Author(s)
      Yasunobu Sawaji, Hidekazu Suzuki, Kenji Endo, Hidetoshi Tanaka, Taiichi Kosaka, Kengo Yamamoto
    • Organizer
      The International Society for the Study of Lumbar Spine
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2015-06-08 – 2015-06-12
    • Related Report
      2014 Research-status Report
  • [Presentation] PGE2 negatively regulates MMP-1 expression by inducing DUSP-1 in human intervertebral disc cells2015

    • Author(s)
      Makiko Yorifuji, Yasunobu Sawaji, Hidekazu Suzuki, Kenji Endo, Hietoshi Tanaka, Taiichi Kosaka, Kengo Yamamoto
    • Organizer
      The International Society for the Study of the Lumbar Spine
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2015-06-08 – 2015-06-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 椎間板性腰痛に関わる神経成長因子のプロスタグランジンによる発現制御機構2015

    • Author(s)
      澤地恭昇,村田寿馬,鈴木秀和,遠藤健司,依藤麻紀子,田中英俊,小坂泰一,山本謙吾
    • Organizer
      第44回 日本脊椎脊髄病学会学術集会
    • Place of Presentation
      福岡県久留米市
    • Year and Date
      2015-04-16 – 2015-04-18
    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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