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Stage and Site Specific Sensitivity of Fecal Immunochemical Tests for Large Advanced Adenomas and Cancers

Research Project

Project/Area Number 25460785
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Epidemiology and preventive medicine
Research InstitutionNational Cancer Center Japan

Principal Investigator

Matsuda Takahisa  国立研究開発法人国立がん研究センター, 中央病院, 検診センター長 (30508049)

Co-Investigator(Kenkyū-buntansha) KAKUGAWA Yasuo  国立がん研究センター中央病院, 内視鏡科, 医長 (00537889)
OONO Yasuhiro  国立がん研究センター東病院, 消化管内視鏡科, 医員 (50602025)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords大腸癌 / スクリーニング / 便潜血検査 / 診断感度 / 部位別検討 / 便潜血検査免疫法 / 大腸腫瘍 / 便潜血 / 免疫法 / 定量化
Outline of Final Research Achievements

Although fecal immunochemical test (FIT) has been widely adopted in many population based colorectal cancer (CRC) screening programs, its stage- and anatomical site-specific sensitivity for advanced colorectal neoplasms remains unclear. A total of 333 subjects [mean age: 63.9years, 176 males (52.9%)]with advanced neoplasms were prospectively enrolled. Of them, 219 had cancerous lesions [Tis (carcinoma in situ):54, T1:48, and T2 to T4:117]. The sensitivity of FIT for advanced adenoma, Tis, T1, and T2-4 cancers were 45.6% (36.3-55.2%), 48.1% (34.5-62.0%), 77.1% (62.3-87.5%), and 91.5% (84.5-95.6%), respectively. FIT had significantly lower sensitivity for proximally located lesions than distal ones in advanced adenomas (34.8% vs. 60.4%, P=0.008), cancers (64.5% vs. 84.6%, P=0.001), and invasive cancers (76.0% vs. 92.2%, P=0.006). FIT had significantly lower sensitivity for proximal located and early cancerous lesions.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (3 results)

All 2015 Other

All Int'l Joint Research (1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Int'l Joint Research] 国立台湾大学(台湾)

    • Related Report
      2015 Annual Research Report
  • [Presentation] Stage and site specific sensitivity of fecal immunochemical testing for large advanced adenoma and cancers – A prospective multi-national, multi-center study2015

    • Author(s)
      松田 尚久
    • Organizer
      米国消化器病週間(DDW)
    • Place of Presentation
      米国:ワシントン
    • Year and Date
      2015-05-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Stage and Site Specific Sensitivity of Fecal Immunochemical Tests for Large Advanced Adenoma and Cancers - A Prospective Multi-national, Multi-center Study2015

    • Author(s)
      松田尚久
    • Organizer
      米国DDW
    • Place of Presentation
      ワシントン(米国)
    • Year and Date
      2015-05-16 – 2015-05-19
    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2022-02-16  

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