Stage and Site Specific Sensitivity of Fecal Immunochemical Tests for Large Advanced Adenomas and Cancers

• Project/Area Number: 25460785
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: National Cancer Center Japan
• Principal Investigator: Matsuda Takahisa 国立研究開発法人国立がん研究センター, 中央病院, 検診センター長 (30508049)
• Co-Investigator(Kenkyū-buntansha): KAKUGAWA Yasuo 国立がん研究センター中央病院, 内視鏡科, 医長 (00537889) ; OONO Yasuhiro 国立がん研究センター東病院, 消化管内視鏡科, 医員 (50602025)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 大腸癌 / スクリーニング / 便潜血検査 / 診断感度 / 部位別検討 / 便潜血検査免疫法 / 大腸腫瘍 / 便潜血 / 免疫法 / 定量化

Outline of Final Research Achievements

Although fecal immunochemical test (FIT) has been widely adopted in many population based colorectal cancer (CRC) screening programs, its stage- and anatomical site-specific sensitivity for advanced colorectal neoplasms remains unclear. A total of 333 subjects [mean age: 63.9years, 176 males (52.9%)]with advanced neoplasms were prospectively enrolled. Of them, 219 had cancerous lesions [Tis (carcinoma in situ):54, T1:48, and T2 to T4:117]. The sensitivity of FIT for advanced adenoma, Tis, T1, and T2-4 cancers were 45.6% (36.3-55.2%), 48.1% (34.5-62.0%), 77.1% (62.3-87.5%), and 91.5% (84.5-95.6%), respectively. FIT had significantly lower sensitivity for proximally located lesions than distal ones in advanced adenomas (34.8% vs. 60.4%, P=0.008), cancers (64.5% vs. 84.6%, P=0.001), and invasive cancers (76.0% vs. 92.2%, P=0.006). FIT had significantly lower sensitivity for proximal located and early cancerous lesions.

Research Products

• [Int'l Joint Research] 国立台湾大学(台湾)
• [Presentation] Stage and site specific sensitivity of fecal immunochemical testing for large advanced adenoma and cancers – A prospective multi-national, multi-center study (2015)
  • Author(s): 松田 尚久
  • Organizer: 米国消化器病週間（DDW）
  • Place of Presentation: 米国：ワシントン
  • Year and Date: 2015-05-18
  • Int'l Joint Research
• [Presentation] Stage and Site Specific Sensitivity of Fecal Immunochemical Tests for Large Advanced Adenoma and Cancers - A Prospective Multi-national, Multi-center Study (2015)
  • Author(s): 松田尚久
  • Organizer: 米国DDW
  • Place of Presentation: ワシントン（米国）
  • Year and Date: 2015-05-16 – 2015-05-19