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Indium exposure in the hair of workers dealing with indium compounds

Research Project

Project/Area Number 25460806
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hygiene and public health
Research InstitutionKyushu University

Principal Investigator

Hirata Mikyuki  九州大学, 医学(系)研究科(研究院), 助教 (30156674)

Co-Investigator(Kenkyū-buntansha) TANAKA Akiyo  九州大学, 医学研究院, 講師 (10136484)
NAKANO Makiko  慶應義塾大学, 医学部, 講師 (70384906)
TANAKA Shigeru  十文字学園女子大学, 人間生活学部, 教授 (60171758)
YONEMOTO Koji  久留米大学, バイオ統計センター, 講師 (90398090)
Research Collaborator MIYAUCHI Hiroyuki  
SUGIYAMA Takeharu  
KAMITANI Kazuyuki  
HANADA Kenji  
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywordsインジウム / 作業者 / 毛髪 / 汚染 / 作業環境 / 付着 / 曝露 / 放射光分析 / XAFS / 毛髪汚染
Outline of Final Research Achievements

To prevent workers from indium exposure in the workplaces of producing or handling of indium compounds including ITO, workers are mandated to effective respiratory protective equipment. The hair of workers is exposed by indium up to ug/g, but there is no attention to hair exposure.
In this study, personal breathing zone samplings and hair samplings of workers was examined for indium exposure. Indium concentrations of hair at morning and evening were increased dose-dependently to breathing zone concentrations of total indium dust, respectively. Spectroscopic analysis using synchrotron radiation by SPring-8 revealed indium chemical adsorption in the surface of hair.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (46 results)

All 2015 2014 2013 Other

All Journal Article (10 results) (of which Peer Reviewed: 9 results,  Open Access: 6 results,  Acknowledgement Compliant: 3 results) Presentation (36 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results)

  • [Journal Article] Pulmonary effects in workers exposed to indium metal: A cross-sectional study2015

    • Author(s)
      M.Nakano, A.Tanaka, M. Hirata, S. Iwasawa, K. Omae
    • Journal Title

      Journal of Occupational Health

      Volume: 57 Issue: 4 Pages: 346-352

    • DOI

      10.1539/joh.14-0262-OA

    • NAID

      130005106131

    • ISSN
      1341-9145, 1348-9585
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Tissue distribution of indium after repeated intratracheal instillations of indium-tin oxide into the lungs of hamsters2015

    • Author(s)
      A.Tanaka, M. Hirata, N. Matsumura, Y. Kiyohara
    • Journal Title

      Journal of Occupational Health

      Volume: 57 Issue: 2 Pages: 189-192

    • DOI

      10.1539/joh.14-0123-BR

    • NAID

      130005066083

    • ISSN
      1341-9145, 1348-9585
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] インジウムの健康影響2015

    • Author(s)
      田中昭代、平田美由紀、中野真規子、大前和幸
    • Journal Title

      アレルギー・免疫

      Volume: 22 Pages: 17-24

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparative study on the pulmonary toxicity of indium hydroxide, indium-tin oxide, and indium oxide following intratracheal instillations into the lungs of rats2015

    • Author(s)
      5.Tanaka A, Hirata M, Matsumura N, Koga K, Shiratani M,Kiyohara Y
    • Journal Title

      MRS Symposium Proceedings/MRS Online Proceeding Library

      Volume: 1723 Pages: 8-13

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tissue distribution of indium after repeated intratracheal instillations of indium-tin oxide into the lungs of hamsters2015

    • Author(s)
      Tanaka A, Hirata M, Matsumura N, Kiyohara Y
    • Journal Title

      Journal Occupatuional Health

      Volume: 57 Pages: 189-192

    • NAID

      130005066083

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Five-year cohort study: emphysematous progression of indium-exposed workers.2014

    • Author(s)
      Nakano M, Omae K, Uchida K, Michikawa T, Yoshioka N, Hirata M, Tanaka A
    • Journal Title

      Chest

      Volume: 146 Issue: 5 Pages: 1166-1175

    • DOI

      10.1378/chest.13-2484

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effects of indium exposure on the lungs of workers: A cross-sectional study2014

    • Author(s)
      Nakano M, Omae K, Iwasawa S, HIrata M, Tanaka A
    • Journal Title

      European Respiratory Journal

      Volume: 44

    • Related Report
      2014 Research-status Report
  • [Journal Article] インジウムの健康影響2014

    • Author(s)
      中野真規子、大前和幸
    • Journal Title

      日本臨床

      Volume: 72 Pages: 317-322

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] KL-6 is Not Ineffective Biomarker of Indium Lung2013

    • Author(s)
      Nakano M, Omae K, Tanaka A, Hirata M
    • Journal Title

      Int A rch O ccup Environ Health

      Volume: 86 Issue: 7 Pages: 845-846

    • DOI

      10.1007/s00420-013-0873-x

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 太陽電池素材の生体影響-インジウムの経気道性吸入による実験的研究-2013

    • Author(s)
      田中昭代、平田美由紀
    • Journal Title

      日本衛生学雑誌

      Volume: 68 Pages: 83-87

    • NAID

      130003369662

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] インジウム:吸入性粉塵曝露濃度と生物学的モニタリング指標の関係2015

    • Author(s)
      大前和幸、中野真規子、岩澤聡子、田中昭代、平田美由紀、田中 茂、宮内博幸、東久保一朗、川澄八重子
    • Organizer
      産業中毒・生物学的モニタリング研究会
    • Place of Presentation
      松本市
    • Year and Date
      2015-10-25 – 2015-10-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Health effects of indium nanoparticles2015

    • Author(s)
      6.Tanaka A, Hirata M, Matsumura N, Koga K, Shiratani M,Kiyohara Y
    • Organizer
      The 10th Asian-European International Conference on Plasma Surface Engineering
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2015-09-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Serum surfactant protein D is a marker of lung injury caused by indium chloride2015

    • Author(s)
      Tanaka A, Hirata M, Matsumura N, Kiyohara Y
    • Organizer
      31th International Cogress on Occupational Health
    • Place of Presentation
      Korea
    • Year and Date
      2015-05-31 – 2015-06-05
    • Related Report
      2014 Research-status Report
  • [Presentation] Serum surfactant protein D is a marker of lung injury caused by indium chloride2015

    • Author(s)
      Tanaka A, Hirata M, Matsumura N, Kiyohara Y
    • Organizer
      31th International Congress on Occupational Health
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2015-05-31
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] インジウム作業者の毛髪汚染2015

    • Author(s)
      平田美由紀
    • Organizer
      第8回インジウムの健康影響に関する情報交換会
    • Place of Presentation
      大阪市
    • Year and Date
      2015-05-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] インジウム曝露ラット肺におけるマイクロRNA発現の網羅的解析2015

    • Author(s)
      平工雄介、田中昭代、平田美由紀、村田真理子
    • Organizer
      第88回 日本産業衛生学会
    • Place of Presentation
      大阪
    • Year and Date
      2015-05-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] インジウムを含む太陽電池素材CIGSの亜慢性影響評価2015

    • Author(s)
      田中昭代、平田美由紀、松村 渚、清原 裕
    • Organizer
      第88回 日本産業衛生学会
    • Place of Presentation
      大阪
    • Year and Date
      2015-05-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] インジウムの吸入性粉塵個人曝露濃度と生物学的モニタリング指標との関係2015

    • Author(s)
      岩澤聡子、中野真規子、田中昭代、平田美由紀、田中 茂、宮内博幸、東久保一朗、川澄八重子、大前和幸
    • Organizer
      第88回 日本産業衛生学会
    • Place of Presentation
      大阪
    • Year and Date
      2015-05-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] インジウム曝露と血清LDHの関係:時間断面観察2015

    • Author(s)
      中野真規子、田中昭代、平田美由紀、吉岡範幸、大前和幸
    • Organizer
      第88回 日本産業衛生学会
    • Place of Presentation
      大阪
    • Year and Date
      2015-05-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] インジウムを含む太陽電池素材CIGSの亜慢性影響評価2015

    • Author(s)
      田中昭代、平田美由紀、松村 渚、清原 裕
    • Organizer
      第88回日本産業衛生学会
    • Place of Presentation
      大阪
    • Year and Date
      2015-05-13 – 2015-05-16
    • Related Report
      2014 Research-status Report
  • [Presentation] インジウム曝露と血清LDHの関係:時間断面研究2015

    • Author(s)
      中野真規子、田中昭代、平田美由紀、吉岡範幸、大前和幸
    • Organizer
      第88回日本産業衛生学会
    • Place of Presentation
      大阪
    • Year and Date
      2015-05-13 – 2015-05-16
    • Related Report
      2014 Research-status Report
  • [Presentation] インジウム曝露ラット肺におけるµ1RNA発言の網羅的解析2015

    • Author(s)
      平工雄介、田中昭代、平田美由紀、村田真理子
    • Organizer
      第88回日本産業衛生学会
    • Place of Presentation
      大阪
    • Year and Date
      2015-05-13 – 2015-05-16
    • Related Report
      2014 Research-status Report
  • [Presentation] インジウムの吸入性粉塵個人曝露濃度と生物学的モニタリング2015

    • Author(s)
      岩澤聡子、中野真規子、田中昭代、平田美由紀、田中 茂、宮内博幸、東久保一朗、川澄八重子、大前和幸
    • Organizer
      第88回日本産業衛生学会
    • Place of Presentation
      大阪
    • Year and Date
      2015-05-13 – 2015-05-16
    • Related Report
      2014 Research-status Report
  • [Presentation] インジウム化合物吸入ラットにおける肺影響指標SP-Dの肺障害マーカーの有効性2015

    • Author(s)
      田中 昭代、平田美由紀、松村 渚、清原 裕
    • Organizer
      第85回日本衛生学会学術総会
    • Place of Presentation
      和歌山
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] ラットに皮下投与したInナノ粒子の体内輸送2015

    • Author(s)
      古閑一憲、天野孝昭、平田美由紀、田中昭代、白谷正治
    • Organizer
      第62回応用物理学会春季学術講演会
    • Place of Presentation
      平塚市
    • Year and Date
      2015-03-11 – 2015-03-14
    • Related Report
      2014 Research-status Report
  • [Presentation] Pulmonary Toxicity of Indium-Tin Oxide and indium Hydroxide Following Intratracheal Instillations Into the Lung of Rats2014

    • Author(s)
      Tanaka A, Hirata M, Matsumura N, Koga K, Shiratani M, Kiyohara Y
    • Organizer
      2014 Material Research Society Fall Metting & Exhibit
    • Place of Presentation
      Boston
    • Year and Date
      2014-11-30 – 2014-12-05
    • Related Report
      2014 Research-status Report
  • [Presentation] Adverse Health Effects of Indium Tin Oxide and Copper Indium Gallium Diselenide2014

    • Author(s)
      Tanaka A, Hirata M, Matsumura N, Koga K, Shiratani M, Kiyohara Y
    • Organizer
      The 6th World Conference on Photovoltaic Energy Conversion
    • Place of Presentation
      京都
    • Year and Date
      2014-11-23 – 2014-11-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Subchronic Pulmonary Toxicity of Copper Indium Gallium Diselenide Following Repeated Intraracheal Instillaitons into the Lungs of Rats2014

    • Author(s)
      Tanaka A, Hirata M, Matsumura N, Koga K, Shiratani M, Kiyohara Y
    • Organizer
      The 21 Asian Conference on Occupational Health
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-02 – 2014-09-04
    • Related Report
      2014 Research-status Report
  • [Presentation] Personal Indium Exposure Concentration in Respirable Dusts and Serum Indium Level2014

    • Author(s)
      Iwasawa S, Nakano M, Miyauchi H, Tanaka S, Tanaka A, Hirata M, Omae K
    • Organizer
      The 21th Asian Conference on Occupational Health
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-02 – 2014-09-04
    • Related Report
      2014 Research-status Report
  • [Presentation] インジウム系太陽電池素材CIGSの経気道曝露における肺影響指標SP-Dの有効性の検討2014

    • Author(s)
      田中昭代、平田美由紀、松村 渚、清原 裕
    • Organizer
      第25回日本微量元素学会
    • Place of Presentation
      岡山
    • Year and Date
      2014-07-03 – 2014-07-04
    • Related Report
      2014 Research-status Report
  • [Presentation] 水酸化インジウム吸入による肺障害の経時的変化2014

    • Author(s)
      田中 昭代、平田美由紀、松村 渚、清原 裕
    • Organizer
      第84回日本衛生学会学術総会
    • Place of Presentation
      岡山
    • Year and Date
      2014-05-25 – 2014-05-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 金属インジウム曝露作業者の肺影響に関する時間断面的研究2014

    • Author(s)
      中野真規子、田中昭代、平田美由紀、岩澤聡子、大前和幸
    • Organizer
      第87回日本産業衛生学会
    • Place of Presentation
      岡山
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Research-status Report
  • [Presentation] インジウム化合物曝露における肺影響指標SP-Dの有効性の検討2014

    • Author(s)
      田中昭代、平田美由紀、松村 渚、清原 裕
    • Organizer
      第87回日本産業衛生学会
    • Place of Presentation
      岡山
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Research-status Report
  • [Presentation] インジウムリサイクル工場における作業環境改善の一例2014

    • Author(s)
      宮内博幸、蓑添 葵、田中 茂、平田美由紀、田中昭代、中野真規子、大前和幸
    • Organizer
      第87回日本産業衛生学会
    • Place of Presentation
      岡山
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Research-status Report
  • [Presentation] Tissue Distribution of Indium ASfter Repeated Intratracheal Instillations of Indium-Tin Oxide in Hamsters2014

    • Author(s)
      Tanaka A, Hirata M, Matsumura N, Koga K, Shiratani M, Kiyohara Y
    • Organizer
      5th International Conference on Plasma Medicine
    • Place of Presentation
      奈良
    • Year and Date
      2014-05-18 – 2014-05-23
    • Related Report
      2014 Research-status Report
  • [Presentation] インジウム錫酸化化合物(ITO)研磨工場におけるインジウムコホート研究(7年間)2014

    • Author(s)
      中野真規子、田中昭代、平田美由紀、岩澤聡子、大前和幸
    • Organizer
      第54回日本呼吸器学会学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2014-04-25 – 2014-04-27
    • Related Report
      2014 Research-status Report
  • [Presentation] RFスパッタリングによるInナノ粒子の作製とその体内動態2014

    • Author(s)
      天野孝昭、古閑一憲、Thapanut Sarinont, 板垣奈穂、白谷正治、林 信哉、中津可道、續 輝久、平田美由紀、田中昭代
    • Organizer
      第61回応用物理学会 春季大会
    • Place of Presentation
      相模原、神奈川
    • Related Report
      2013 Research-status Report
  • [Presentation] Subacute toxicity of gallium arsenide, indium arsenide and arsenic trioxide following intermittent intratracheal instillations to the lung of rats2014

    • Author(s)
      Tanaka A, Hirata M, Koga K, Itagaki N, Shiratani M, Hayashi N, Uchida G.
    • Organizer
      8th International Conference on Reactive Plasmas/31st Symposium on Plasma Processing
    • Place of Presentation
      Fukuoka
    • Related Report
      2013 Research-status Report
  • [Presentation] Safety issues on plasma life science2013

    • Author(s)
      Shiratani M, Koga K., Tanaka A, Hirata M. Hayashim H. Itagaki N. Uchida G.
    • Organizer
      The 9th Asian-European International Conference on Plasma Surface Engineering
    • Place of Presentation
      Jeju Iland, Korea
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Pulmonary Toxicity of copper indium gallium diselenide particles in rats2013

    • Author(s)
      Tanaka A, Hirata M, Koga K, Hayashi N., Shiratani M., Kiyohara Y
    • Organizer
      6th International Symposium on Nanotechnology
    • Place of Presentation
      Nagoya
    • Related Report
      2013 Research-status Report
  • [Presentation] Comparative acute pulmonary toxicity of different types of indium-tin oxide following intermittent intratracheal instillation to the lung of rats2013

    • Author(s)
      Koga K., Tanaka A., Hirata M., Hayashi N., Itagaki N
    • Organizer
      JSAP-MRS
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Research-status Report
  • [Presentation] カドミウム・テルルの経気道性曝露による亜慢性影響2013

    • Author(s)
      田中昭代、平田美由紀、松村 渚、清原 裕
    • Organizer
      第24回日本微量元素学会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] 水酸化インジウムの経気道性曝露による長期生体影響2013

    • Author(s)
      田中昭代、平田美由紀、清原 裕
    • Organizer
      第86回日本産業衛生学会
    • Place of Presentation
      松山
    • Related Report
      2013 Research-status Report
  • [Presentation] ITO取扱い作業場における面体形(半面)電動ファン付き呼吸用保護具の有効性について2013

    • Author(s)
      田中 茂、宮内博幸、平田美由紀、田中昭代、中野真規子、大前和幸
    • Organizer
      第86回日本産業衛生学会
    • Place of Presentation
      松山
    • Related Report
      2013 Research-status Report
  • [Presentation] ITO取扱い作業場におけるインジウムと粉じんの作業環境測定について2013

    • Author(s)
      宮内博幸、田中 茂、平田美由紀、田中昭代、中野真規子、大前和幸
    • Organizer
      第86回日本産業衛生学会
    • Place of Presentation
      松山
    • Related Report
      2013 Research-status Report
  • [Presentation] Toxicity of indium compounds in laboratory animals

    • Author(s)
      Tanaka A., Hirata M., Kiyohara Y.
    • Organizer
      8th International Conference on Reactive Plasmas/31st symposium on plasma processing
    • Place of Presentation
      Fukuoka
    • Related Report
      2013 Research-status Report
    • Invited

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Published: 2014-07-25   Modified: 2019-07-29  

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