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The development of new indicators and preventive methods for early detection of the tendency of autism: the association between food and allergy

Research Project

Project/Area Number 25460830
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hygiene and public health
Research InstitutionKansai University of Welfare Sciences

Principal Investigator

SAGARA Takiko  関西福祉科学大学, 健康福祉学部, 教授 (30249164)

Co-Investigator(Kenkyū-buntansha) 中村 裕之  金沢大学, 医学系, 教授 (30231476)
三辺 義雄  金沢大学, 医学系, 教授 (60181947)
人見 嘉哲  金沢大学, 医学系, 准教授 (70231545)
神林 康弘  金沢大学, 医学系, 講師 (20345630)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsアレルギー / 自閉症 / 体重 / アトピー性皮膚炎 / 気管支喘息 / 食 / 小児 / 食育 / 栄養 / 環境 / コホート / 予防
Outline of Final Research Achievements

We performed a cross-sectional survey to examine the prevalence of symptoms of eczema, asthma, rhinoconjunctivitis and autism spectrum disorder and to elucidate the associations between them. The participants were 337 children aged 3-6 years attending kindergarten or nursery school in Shika town, Japan. Autism spectrum feature was scored on the Social Communication Questionnaire (SCQ). The prevalence of symptoms was 11.3% for eczema, 14.8% for asthma, and 5.3% for rhinoconjunctivitis. A total of 15 children (4.5%) had the SCQ score of 11 points or over. The logistic regression indicated that eczema symptom was significantly associated with the SCQ score of 11 points or over. The association persisted after adjusted for age, gender, and BMI. Moreover, asthma symptom was significantly associated with boy and overweight. The result suggested that high SCQ score, which implies autism spectrum traits, might be an important risk factor for eczema.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (27 results)

All 2017 2016 2015 2014 2013

All Journal Article (12 results) (of which Peer Reviewed: 12 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (8 results) Book (7 results)

  • [Journal Article] Prevalence of Chronic Pain, Especially Headache, and Relationship with Health-Related Quality of Life in Middle-Aged Japanese Residents.2016

    • Author(s)
      Mitoma J, Kitaoka M, Asakura H, Anyenda EO, Hori D, Nguyen TT, Hamagishi T, Hayashi K, Suzuki F, Shimizu Y, Tsujiguchi H, Kambayashi Y, Hibino Y, Konoshita T, Sagara T, Shibata A, Nakamura H
    • Journal Title

      Health

      Volume: 8 Issue: 01 Pages: 116-124

    • DOI

      10.4236/health.2016.81014

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Preventive effects of ramelteon on delirium: a randomized placebo-controlled trial2014

    • Author(s)
      Hatta K, Kishi Y, Wada K, Takeuchi T, Odawara T, Usui C, Nakamura H; DELIRIA-J Group
    • Journal Title

      JAMA Psychiatry

      Volume: 71 Issue: 4 Pages: 397-403

    • DOI

      10.1001/jamapsychiatry.2013.3320

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Theobromine, the primary methylxanthine found in Theobroma cacao, prevents malignant glioblastoma proliferation by negatively regulating phosphodiesterase-4, extracellular signal-regulated kinase, Akt/mammalian target of rapamycin kinase, and nuclear factor-kappa B2014

    • Author(s)
      Sugimoto N, Miwa S, Hitomi Y, Nakamura H, Tsuchiya H, Yachie A
    • Journal Title

      Nutr Cancer

      Volume: 66(3) Issue: 3 Pages: 419-23

    • DOI

      10.1080/01635581.2013.877497

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Consumption of green tea, but not black tea or coffee, is associated with reduced risk of cognitive decline.2014

    • Author(s)
      Noguchi-Shinohara M, Yuki S, Dohmoto C, Ikeda Y, Samuraki M, Iwasa K, Yokogawa M, Asai K, Komai K, Nakamura H, Yamada M.
    • Journal Title

      PLoS One

      Volume: 14;9(5) Issue: 5 Pages: e96013-e96013

    • DOI

      10.1371/journal.pone.0096013

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] A novel coronary active perfusion system using a conventional intra-aortic balloon pump for off-pump coronary artery bypass grafting.2014

    • Author(s)
      Kiuchi R, Tomita S, Yamaguchi S, Nishida Y, Ohtake H, Nakamura H, Watanabe G
    • Journal Title

      J Thorac Cardiovasc Surg

      Volume: 48(1) Issue: 1 Pages: 304-310

    • DOI

      10.1016/j.jtcvs.2013.11.049

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] High sensitivity of late gadolinium enhancement for predicting microscopic myocardial scarring in biopsied specimens in hypertrophic cardiomyopathy.2014

    • Author(s)
      Konno T,Hayashi K,Fujino N,Nagata Y,Hodatsu A,Masuta E,Sakata K,Nakamura H,Kawashiri M,Yamagishi M.
    • Journal Title

      PLoS One.

      Volume: 9 Issue: 7 Pages: e101465-e101465

    • DOI

      10.1371/journal.pone.0101465

    • NAID

      120006460361

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Asian dust on daily cough occurrence in patients with chronic cough: A panel study.2014

    • Author(s)
      Higashi T, Kambayashi Y, Ohkura N, Fujimura M, Nakai S, Honda Y, Saijoh K, Hayakawa K, Kobayashi F, Michigami Y, Anyenda EO, Hitomi Y, Nakamura H.
    • Journal Title

      Atmospheric Environment

      Volume: 92 Pages: 506-513

    • DOI

      10.1016/j.atmosenv.2014.04.034

    • NAID

      120005463354

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical impacts of albuminuria and glomerular filtration rate on renal, cardiovascular events, and all-cause mortality in Japanese patients with type 2 diabetes.2014

    • Author(s)
      Wada T, Haneda M, Furuichi K, Babazono T, Yokoyama H, Iseki K, Araki SI, Ninomiya T, Hara S, Suzuki Y, Iwano M, Kusano E, Moriya T, Satoh H, Nakamura H, Shimizu M, Toyama T, Hara A, Makino H; The Research Group of Diabetic Nephropathy, Ministry of Health, Labour, and Welfare of Japan
    • Journal Title

      Clin Exp Nephrol

      Volume: - Issue: 4 Pages: 613-620

    • DOI

      10.1007/s10157-013-0879-4

    • NAID

      120005411654

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Erratum to: Clinical impact of albuminuria and glomerular filtration rate on renal and cardiovascular events, and all-cause mortality in Japanese patients with type 2 diabetes.2014

    • Author(s)
      Wada T, Haneda M, Furuichi K, Babazono T, Yokoyama H, Iseki K, Araki SI, Ninomiya T, Hara S, Suzuki Y, Iwano M, Kusano E, Moriya T, Satoh H, Nakamura H, Shimizu M, Toyama T, Hara A, Makino H, The Research Group of Diabetic Nephropathy, Ministry of Health, Labour, and Welfare of Japan.
    • Journal Title

      Clin Exp Nephrol

      Volume: 18(4) Issue: 4 Pages: 621-622

    • DOI

      10.1007/s10157-013-0931-4

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Long-term Heat Exposure Prevents Hypoxia-Induced Apoptosis in Mouse Fibroblast Cells2014

    • Author(s)
      Sugimoto N, Shido O, Matsuzaki K, Katakura M, Hitomi Y, Tanaka M, Sawaki T, Fujita Y, Kawanami T, Masaki Y, Okazaki T, Nakamura H, Koizumi S, Yachie A and Umehara H
    • Journal Title

      Cell biochemistry and biophysics

      Volume: (in press) Issue: 1 Pages: 301-7

    • DOI

      10.1007/s12013-014-9912-9

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Epidemiological link between wheat allergy and exposure to hydrolyzed wheat protein in facial soap.2014

    • Author(s)
      Fukutomi Y, Taniguchi M, Nakamura H, Akiyama K.
    • Journal Title

      Allergy.

      Volume: 69(10) Issue: 10 Pages: 1405-1411

    • DOI

      10.1111/all.12481

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Exacerbation of daily cough and allergic symptpms in adult patients with chronic cough by Asian dust: A hospital-based study in Kanazawa2014

    • Author(s)
      Higashi T, Kambayashi Y, Ohkura N, Fujimura M, Nakanishi S, Yoshizaki T, Saijoh K, Hayakawa K, Kobayashi F, Michigami Y, Hitomi Y, and Nakamura H
    • Journal Title

      Atmospheric Environment

      Volume: in press Pages: 537-543

    • DOI

      10.1016/j.atmosenv.2014.01.041

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 幼児の心の発達と生活環境因子について2017

    • Author(s)
      相良多喜子
    • Organizer
      第64回日本栄養改善学会学術総会
    • Place of Presentation
      アスティとくしま(徳島県)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 女子大学生の疲労自覚症状に関わる要因の検討2015

    • Author(s)
      相良多喜子
    • Organizer
      第62回日本栄養改善学会学術総会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2015-09-24
    • Related Report
      2015 Research-status Report
  • [Presentation] 小中学校児童生徒の自閉症傾向は、体型および栄養状態と関連する2015

    • Author(s)
      堀大介、辻口博聖、神林康弘、濱岸利夫、北岡政美、三苫純子、朝倉大貴、鈴木史彦、Anyenda Enoch Olando、Nguyen Thi Thu Thao、中村剛、木戸康人、能登裕幸、荒舩丈一、清水由加里、林宏一郎、日比野由利、柴田亜樹、相良多喜子、笹原信一朗、松崎一葉、中村裕之
    • Organizer
      第25回体力・栄養・免疫学会大会
    • Place of Presentation
      帝京科学大学(東京)
    • Year and Date
      2015-08-22
    • Related Report
      2015 Research-status Report
  • [Presentation] 生活習慣および精神的健康度と健診受診行動との関連2015

    • Author(s)
      辻口博聖、堀大介、神林康弘、朝倉大貴、北岡政美、三苫純子, Anyenda Enoch Olando, Nguyen Thi Thu Thao、濱岸利夫、中村剛、木戸康人、能登裕幸、鈴木史彦、荒舩丈一、清水由加里、林宏一郎、日比野由利、柴田亜樹、相良多喜子、中村裕之
    • Organizer
      第13回日本予防医学会学術総会
    • Place of Presentation
      フレンドパーク石川(石川県)
    • Year and Date
      2015-06-20
    • Related Report
      2015 Research-status Report
  • [Presentation] 精神的健康度と性,年代,生活習慣要因の関連-金沢市一般住民の横断調査2015

    • Author(s)
      堀大介、辻口博聖、神林康弘、濱岸利夫、北岡政美、三苫純子、朝倉大貴、鈴木史彦, Anyenda Enoch Olando, Nguyen Thi Thu Thao、中村 剛、木戸康人、能登裕幸、荒舩丈一、清水由加里、林宏一郎、日比野由利、柴田亜樹、相良多喜子、笹原信一朗、松崎一葉、中村裕之
    • Organizer
      第13回日本予防医学会学術総会
    • Place of Presentation
      フレンドパーク石川(石川県)
    • Year and Date
      2015-06-20
    • Related Report
      2015 Research-status Report
  • [Presentation] INVESTIGATION ABOUT THE BREAKFAST INTAKE COMPARISON BETWEEN DIETITIAN COURSE STUDENT AND THE OTHER STUDENT2014

    • Author(s)
      Naomi Katayama, Chizuko Hotta, Takiko Sagara
    • Organizer
      第6回アジア栄養士会議
    • Place of Presentation
      台北市国際会議場(台湾)
    • Year and Date
      2014-08-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 児童生徒における食生活実態調査の検討2013

    • Author(s)
      相良多喜子、桑守豊美
    • Organizer
      第60回日本栄養改善学会学術総会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] 中学生における食に関する指導の実践2013

    • Author(s)
      相良多喜子
    • Organizer
      第12回日本栄養改善学会近畿支部学術総会
    • Place of Presentation
      千里金蘭大学
    • Related Report
      2013 Research-status Report
  • [Book] 給食の運営 給食計画・実務編 第5版2016

    • Author(s)
      富岡和夫、笹田陽子、相良多喜子、佐藤玲子、杉本温美、高野美幸、西川貴子
    • Total Pages
      272
    • Publisher
      医歯薬出版
    • Related Report
      2016 Annual Research Report
  • [Book] 栄養教育論―栄養の指導―2016

    • Author(s)
      蕨迫栄美子、関口紀子、相良多喜子、石井幸江、加藤由美子、和田涼子、宇和川小百合
    • Total Pages
      259
    • Publisher
      学建書院
    • Related Report
      2016 Annual Research Report
  • [Book] 「教育と医学」子どもの心の発達と食育の科学2016

    • Author(s)
      相良多喜子
    • Total Pages
      96
    • Publisher
      慶應義塾大学出版
    • Related Report
      2016 Annual Research Report
  • [Book] 学内給食経営管理実習のためのおいしい食事のコーディネート(第2版)2015

    • Author(s)
      木村友子、井上明美、長澤伸江、松井元子、相良多喜子、他4名
    • Total Pages
      171
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2014 Research-status Report
  • [Book] 栄養士課程実習ノート(第6版)2015

    • Author(s)
      相良多喜子、熊沢昭子、間瀬友子、北川公子、片山直美
    • Total Pages
      110
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2014 Research-status Report
  • [Book] カレント給食経営管理論(第2版)2015

    • Author(s)
      宮澤節子、松井元子、相良多喜子、尾木千恵美、加賀谷みえ子、河合潤子、他5名
    • Total Pages
      241
    • Publisher
      株式会社建帛社
    • Related Report
      2014 Research-status Report
  • [Book] 五訂 ライフステージの栄養学 理論と実習2015

    • Author(s)
      桑守豊美、志塚ふじ子、小川宣子、相良多喜子、他5名
    • Total Pages
      265
    • Publisher
      株式会社みらい
    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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