| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The number of patients with food allergy has dramatically increased. Although satisfactory drug therapies for food allergy are not available, we found that kakkonto, a traditional Japanese herbal medicine, suppressed the occurrence of allergic symptoms in a food allergy mouse model. Recently, it has been reported that intestinal mucosal immunity plays an important role in food allergy. Thus, we investigated whether kakkonto could regulate intestinal mucosal immunity of the colon. We demonstrated that kakkonto significantly increased the proportion of regulatory T cells in the colon. The induction of regulatory T cells in the colon as a novel mechanism underlying the therapeutic action of kakkonto could be utilized for the development of a novel anti-food allergy drug.
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