A prospective study of Continuous Geriatric Assessments (GAs) in elderly advanced pancreatic cancer patients treated with gemcitabine-based chemotherapy
| Project/Area Number |
25460913
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 癌 / 医療・福祉 / 医療福祉 / 医療･福祉 |
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| Outline of Final Research Achievements |
Background: We previously reported that the continuous geriatric assessments (GAs) were feasible in elderly pts with GI cancers. It is suggested that the changes in GAs might be useful. Methods: We conducted a prospective study in patients (pts) with pancreatic cancer. The primary end point was overall survival, and the secondary end points were progression free survival, toxicities, and quality of life. Eligible pts were aged 70 years or older; treating with GEM or GEM-nabPTX; and a Performance Status of 0-2. We performed the GAs before initial treatment and every two months after induction. The GAs were; Cancer-Specific Geriatric Assessment (CSGA), MMSE, Frontal Assessment Battery (FAB) and VES-13. Results: 52 pts were enrolled at Kyorin university hospital between July, 2013, and August, 2015. Conclusion: In elderly pts with pancreatic cancer, the continuous GAs were feasible. As this study is on-going, we will explore the relationship between the GAs and clinical outcomes.
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Report
(4 results)
Research Products
(50 results)
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[Journal Article] Multicenter questionnaire survey on patterns of care for elderly patients with esophageal squamous cell carcinoma by the Japan Esophageal Oncology Group2016
Author(s)
Hamamoto Y, Akutsu Y, Nagashima F, Hironaka S, Ito Y, Kato K, Hara H, Tsubosa Y, Nakagawa S, Daiko H, Ozawa S, Kitagawa Y
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Journal Title
Jpn J Clin Oncol
Volume: 46(2)
Pages: 111-115
DOI
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Peer Reviewed
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[Journal Article] 高齢者切除不能大腸癌において治療方針決定に用いる高齢者機能評価の実際とその応用について2015
Author(s)
長島 文夫, 北村 浩, 宮島 謙介, 春日 章良, 成毛 大輔, 岡野 尚弘, 古瀬 純司, 松岡 弘芳, 正木 忠彦, 松井 敏史, 須藤 紀子, 神崎 恒一, 奥山 徹, 明智 龍男安藤 昌彦
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Journal Title
日本大腸肛門病学会雑誌
Volume: 68
Pages: 365-365
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[Journal Article] Phase 1 study of pazopanib alone or combined with lapatinib in Japanese patients with solid tumors2014
Author(s)
Inada-Inoue M1, Ando Y, Kawada K, Mitsuma A, Sawaki M, Yokoyama T, Sunakawa Y, Ishida H, Araki K, Yamashita K, Mizuno K, Nagashima F, Takekura A, Nagamatsu K, Sasaki Y
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Journal Title
Cancer Chemother Pharmacol
Volume: 73(4)
Issue: 4
Pages: 673-83
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Peer Reviewed
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[Journal Article] Regorafenib in Japanese patients with solid tumors: phase I study of safety, efficacy, and pharmacokinetics.2014
Author(s)
2. Sunakawa Y, Furuse J, Okusaka T, Ikeda M, Nagashima F, Ueno H, Mitsunaga S, Hashizume K, Ito Y, Sasaki Y
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Journal Title
Invest New Drugs
Volume: 32(1)
Issue: 1
Pages: 104-12
DOI
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Peer Reviewed
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[Presentation] 高齢者と化学療法2015
Author(s)
長島文夫
Organizer
第13回日本臨床腫瘍学会学術集会
Place of Presentation
札幌市教育文化会館 1F 大ホール(札幌）
Year and Date
2015-07-16
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[Presentation] A multicenter phase II study of gemcitabine plus S-1 chemotherapy for advanced biliary tract cancer
Author(s)
Arima S, Shimizu K, Okamoto T, Toki S, Kasuga A, Kitamura H, Takasu A, Nagashima F, Sugiyama M, Furuse J
Organizer
The European Cancer Congress 2013.abstr2620
Place of Presentation
Amsterdam,Netherlands
Related Report
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